Prognostic value of serum MUC5AC mucin in patients with cholangiocarcinoma

The authors recently showed that MUC5AC mucin, which is expressed aberrantly in tumor tissue, is present in significant concentrations in serum from patients with cholangiocarcinoma. Subsequently, determination of serum MUC5AC had high sensitivity and specificity for cholangiocarcinoma. In this study, the possible association between serum MUC5AC mucin and the clinical findings of the patients and their prognostic value were explored.

[1]  I. Brockhausen,et al.  Mucin glycoproteins in neoplasia , 1996, Glycoconjugate Journal.

[2]  C. Wongkham,et al.  Serum MUC5AC mucin as a potential marker for cholangiocarcinoma. , 2003, Cancer letters.

[3]  L. K. Rasmussen,et al.  Isolation and characterization of MUC15, a novel cell membrane-associated mucin. , 2002, European journal of biochemistry.

[4]  Naoki Matsumura,et al.  Correlation between expression of MUC1 core protein and outcome after surgery in mass‐forming intrahepatic cholangiocarcinoma , 2002, Cancer.

[5]  S. Crawley,et al.  MUC17, a novel membrane-tethered mucin. , 2002, Biochemical and biophysical research communications.

[6]  G. Sutherland,et al.  MUC13, a Novel Human Cell Surface Mucin Expressed by Epithelial and Hemopoietic Cells* , 2001, The Journal of Biological Chemistry.

[7]  K. McMasters,et al.  Bile Duct Carcinoma: Trends in Treatment in the Nineties , 2000, The American surgeon.

[8]  D. Thornton,et al.  Physical characterization of the MUC5AC mucin: a highly oligomeric glycoprotein whether isolated from cell culture or in vivo from respiratory mucous secretions. , 2000, The Biochemical journal.

[9]  T. Irimura,et al.  Expression of MUC1 and MUC2 mucin antigens in intrahepatic bile duct tumors: Its relationship with a new morphological classification of cholangiocarcinoma , 1999, Hepatology.

[10]  D. Gotley,et al.  Two novel mucin genes down-regulated in colorectal cancer identified by differential display. , 1999, Cancer research.

[11]  S. Takao,et al.  Gene expression of gastric type mucin (MUC5AC) in pancreatic tumors: Its relationship with the biological behavior of the tumor , 1999, Pathology international.

[12]  Y. Kim,et al.  Expression of apomucins in the intrahepatic biliary tree in hepatolithiasis differs from that in normal liver and extrahepatic biliary obstruction , 1998, Hepatology.

[13]  B. Clement,et al.  Mucin gene expression in biliary epithelial cells. , 1997, Journal of hepatology.

[14]  S. Yonezawa,et al.  Expression of mucin antigens in human cancers and its relationship with malignancy potential , 1997, Pathology international.

[15]  M. Hollingsworth,et al.  MUC2 gene expression is found in noninvasive tumors but not in invasive tumors of the pancreas and liver: its close relationship with prognosis of the patients. , 1997, Human pathology.

[16]  Y. Kim,et al.  Characterization of apomucin expression in intrahepatic cholangiocarcinomas and their precursor lesions: An immunohistochemical study , 1996, Hepatology.

[17]  Y. Nakanuma,et al.  Abnormal expression of MUC1 apomucin and mature MUC1 mucin in biliary epithelial cells in various cystic liver diseases , 1996, Hepatology.

[18]  M. Price,et al.  Respiratory mucins: identification of core proteins and glycoforms. , 1996, The Biochemical journal.

[19]  H. Kitamura,et al.  Expression of Mucin Carbohydrates and Core Proteins in Carcinomas of the Ampulla of Vater: Their Relationship to Prognosis , 1996, Japanese journal of cancer research : Gann.

[20]  J. Gum.  Human mucin glycoproteins: varied structures predict diverse properties and specific functions. , 1995, Biochemical Society transactions.

[21]  T. Terada,et al.  Biliary epithelial expression of MUC1, MUC2, MUC3 and MUC5/6 apomucins during intrahepatic bile duct development and maturation. An immunohistochemical study. , 1995, The American journal of pathology.

[22]  D. Henson,et al.  Liver, gallbladder, extrahepatic bile ducts, and pancreas , 1995, Cancer.

[23]  J. Taylor‐Papadimitriou,et al.  Exploiting altered glycosylation patterns in cancer: progress and challenges in diagnosis and therapy. , 1994, Trends in biotechnology.

[24]  R. Dahiya,et al.  Heterogeneity of mucin gene expression in normal and neoplastic tissues. , 1993, Cancer research.

[25]  V. Bhavanandan,et al.  Cancer-associated mucins and mucin-type glycoproteins. , 1991, Glycobiology.

[26]  P. Isaacson,et al.  Immunoproliferative small-intestinal disease. An immunohistochemical study. , 1989, The American journal of surgical pathology.

[27]  Tohru Takahashi,et al.  The development and extension of hepatohilar bile duct carcinoma. A three‐dimensional tumor mapping in the intrahepatic biliary tree visualized with the aid of a graphics computer system , 1989, Cancer.

[28]  W. Watkins.  Genetic regulation of the structure of blood-group-specific glycoproteins. , 1974, Biochemical Society symposium.