Luliconazole Demonstrates Potent In Vitro Activity against Dermatophytes Recovered from Patients with Onychomycosis

ABSTRACT The in vitro activities of luliconazole, amorolfine, ciclopirox, and terbinafine were determined against 320 dermatophyte isolates from large toenails of onychomycosis patients enrolled into an ongoing phase 2b/3 clinical study. The geometric mean MIC for luliconazole was 0.00022 μg/ml against all isolates, compared to 0.0194 to 0.3107 μg/ml for the three other agents. The in vitro potency of luliconazole was maintained regardless of the dermatophyte species.

[1]  K. Ferreira-Paim,et al.  Identification and antifungal susceptibility of fungi isolated from dermatomycoses , 2014, Journal of the European Academy of Dermatology and Venereology : JEADV.

[2]  T. Jones,et al.  Safety and Tolerability of Luliconazole Solution 10-Percent in Patients with Moderate to Severe Distal Subungual Onychomycosis , 2013, Antimicrobial Agents and Chemotherapy.

[3]  T. Jones,et al.  Luliconazole for the treatment of interdigital tinea pedis: A double-blind, vehicle-controlled study. , 2013, Cutis.

[4]  A. Fothergill,et al.  Comparison of In Vitro Antifungal Activities of Efinaconazole and Currently Available Antifungal Agents against a Variety of Pathogenic Fungi Associated with Onychomycosis , 2013, Antimicrobial Agents and Chemotherapy.

[5]  C. Janaki,et al.  Comparative Assessment of the Efficacy and Safety of Sertaconazole (2%) Cream Versus Terbinafine Cream (1%) Versus Luliconazole (1%) Cream In Patients with Dermatophytoses: A Pilot Study , 2013, Indian journal of dermatology.

[6]  C. Grover,et al.  An update on treatment of onychomycosis , 2012, Mycoses.

[7]  Maria R R Silva,et al.  Antifungal susceptibility patterns of yeasts and filamentous fungi isolated from nail infection , 2011, Journal of the European Academy of Dermatology and Venereology : JEADV.

[8]  M. Ghannoum,et al.  Efficacy of terbinafine compared to lanoconazole and luliconazole in the topical treatment of dermatophytosis in a guinea pig model. , 2010, Medical mycology.

[9]  K. Makimura,et al.  In vitro antifungal activities of luliconazole, a new topical imidazole. , 2009, Medical mycology.

[10]  J. Szepietowski,et al.  Stigmatisation in onychomycosis patients: a population‐based study , 2009, Mycoses.

[11]  J. Pemán,et al.  Comparison of E-Test, disk diffusion and a modified CLSI broth microdilution (M 38-A) method for in vitro testing of itraconazole, fluconazole and voriconazole against dermatophytes. , 2008, Medical mycology.

[12]  Clinical,et al.  Reference method for broth dilution antifungal susceptibility testing of filamentous fungi : Approved standard , 2008 .

[13]  E. Warshaw,et al.  NailQoL: a quality‐of‐life instrument for onychomycosis , 2007, International journal of dermatology.

[14]  H. Yamaguchi,et al.  In vitro antifungal activity of luliconazole against clinical isolates from patients with dermatomycoses , 2006, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

[15]  A. Gupta,et al.  In vitro activities of posaconazole, ravuconazole, terbinafine, itraconazole and fluconazole against dermatophyte, yeast and non-dermatophyte species. , 2005, Medical mycology.

[16]  M. Ghannoum,et al.  Intra- and Interlaboratory Study of a Method for Testing the Antifungal Susceptibilities of Dermatophytes , 2004, Journal of Clinical Microbiology.

[17]  B. Elewski,et al.  Epidemiologic surveillance of cutaneous fungal infection in the United States from 1999 to 2002. , 2004, Journal of the American Academy of Dermatology.

[18]  H. Yamaguchi,et al.  In vitro antifungal activity of luliconazole (NND-502), a novel imidazole antifungal agent , 2004, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

[19]  B. Elewski,et al.  A large-scale North American study of fungal isolates from nails: the frequency of onychomycosis, fungal distribution, and antifungal susceptibility patterns. , 2000, Journal of the American Academy of Dermatology.

[20]  B S Schlefman,et al.  Onychomycosis: a compendium of facts and a clinical experience. , 1999, The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons.