Big Data and the Brain: Peeking at the Future

CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China Sino-Danish College, University of Chinese Academy of Sciences, Beijing 100049, China 3 Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China

[1]  Jie Li,et al.  Application of Computational Biology to Decode Brain Transcriptomes , 2019, Genom. Proteom. Bioinform..

[2]  Wei Qian,et al.  PsyMuKB: An Integrative De Novo Variant Knowledge Base for Developmental Disorders , 2019, Genom. Proteom. Bioinform..

[3]  Jiguang Wang,et al.  Deciphering Brain Complexity Using Single-cell Sequencing , 2019, Genom. Proteom. Bioinform..

[4]  Mariella G. Filbin,et al.  Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma , 2016, Nature.

[5]  Christina Backes,et al.  Machine Learning to Detect Alzheimer’s Disease from Circulating Non-coding RNAs , 2019, bioRxiv.

[6]  N. Neff,et al.  Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing , 2018, Neuron.

[7]  Matthew F. Glasser,et al.  The Human Connectome Project: Progress and Prospects , 2016, Cerebrum: the Dana Forum on Brain Science.

[8]  James A. Gagnon,et al.  Simultaneous single-cell profiling of lineages and cell types in the vertebrate brain , 2018, Nature Biotechnology.

[9]  Doris Y. Tsao,et al.  The Code for Facial Identity in the Primate Brain , 2017, Cell.

[10]  Åsa K. Björklund,et al.  Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development , 2019, Nature Communications.

[11]  Shawn M. Gillespie,et al.  Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma , 2014, Science.

[12]  Alison Abbott Researchers add live human cells to brain database , 2017 .

[13]  Evan Z. Macosko,et al.  Single‐Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell‐State Changes , 2019, Immunity.

[14]  Haidong Zhu,et al.  How Big Data and High-performance Computing Drive Brain Science , 2019, Genom. Proteom. Bioinform..

[15]  Jia Qian Wu,et al.  Single-cell RNA-sequencing of the brain , 2017, Clinical and Translational Medicine.

[16]  Ulrich Sure,et al.  Edinburgh Research Explorer Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution , 2022 .

[17]  Hui Gong,et al.  Challenges of Processing and Analyzing Big Data in Mesoscopic Whole-brain Imaging , 2019, Genom. Proteom. Bioinform..

[18]  A. McCallion,et al.  Single-Cell RNA-Seq of Mouse Dopaminergic Neurons Informs Candidate Gene Selection for Sporadic Parkinson Disease. , 2018, American journal of human genetics.

[19]  Ning Guo,et al.  Functional Neuroimaging in the New Era of Big Data , 2019, Genom. Proteom. Bioinform..

[20]  Zhenyu Liu,et al.  Identification of Cognitive Dysfunction in Patients with T2DM Using Whole Brain Functional Connectivity , 2019, Genom. Proteom. Bioinform..

[21]  Nancy Y. Ip,et al.  China Brain Project: Basic Neuroscience, Brain Diseases, and Brain-Inspired Computing , 2016, Neuron.

[22]  Bingbing Xie,et al.  GliomaDB: A Web Server for Integrating Glioma Omics Data and Interactive Analysis , 2019, Genom. Proteom. Bioinform..

[23]  Chao Chen,et al.  Brain Banks Spur New Frontiers in Neuropsychiatric Research and Strategies for Analysis and Validation , 2019, Genom. Proteom. Bioinform..

[24]  Jie Qiao,et al.  A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex , 2018, Nature.

[25]  Steven D Chang,et al.  Single-Cell RNAseq analysis of infiltrating neoplastic cells at the migrating front of human glioblastoma , 2017, bioRxiv.

[26]  Justus M. Kebschull,et al.  The logic of single-cell projections from visual cortex , 2018, Nature.

[27]  Guan Ning Lin,et al.  PsyMuKB: A De Novo Variant Knowledge Base Integrating Transcriptional and Translational Information to Identify Isoform-specific Mutations in Developmental Disorders , 2019, bioRxiv.

[28]  Bairong Shen,et al.  Translational Informatics for Parkinson’s Disease: from Big Biomedical Data to Small Actionable Alterations , 2019, Genom. Proteom. Bioinform..

[29]  Mariella G. Filbin,et al.  Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq , 2017, Science.

[30]  Annapurna Poduri,et al.  Single-Cell, Genome-wide Sequencing Identifies Clonal Somatic Copy-Number Variation in the Human Brain , 2014, Cell reports.

[31]  Sean K. Simmons,et al.  Individual brain organoids reproducibly form cell diversity of the human cerebral cortex , 2019, Nature.