Composition and morphology of wear debris in failed uncemented total hip replacement.

Interfacial membranes collected at revision from 11 failed uncemented Ti-alloy total hip replacements were examined. Particles in the membranes were characterised by electron microscopy, microchemical spectroscopy and particle size analysis. Most were polyethylene and had a mean size of 0.53 micron +/- 0.3. They were similar to the particles seen in the base resin used in the manufacture of the acetabular implants. Relatively few titanium particles were seen. Fragments of bone, stainless steel and silicate were found in small amounts. Most of the polyethylene particles were too small to be seen by light microscopy. Electron microscopy and spectroscopic techniques are required to provide an accurate description of this debris.

[1]  W. Wilfinger,et al.  Fluorometric quantification of DNA in cells and tissue. , 1983, Analytical biochemistry.

[2]  J. H. Quastel,et al.  PARTICLE UPTAKE BY POLYMORPHONUCLEAR LEUCOCYTES AND EHRLICH ASCITES-CARCINOMA CELLS. , 1963, The Biochemical journal.

[3]  H. Amstutz,et al.  The pathology of the joint tissues and its clinical relevance in prosthesis failure. , 1976, Clinical orthopaedics and related research.

[4]  W H Harris,et al.  The synovial-like membrane at the bone-cement interface in loose total hip replacements and its proposed role in bone lysis. , 1983, The Journal of bone and joint surgery. American volume.

[5]  C. Gentz,et al.  Localized bone resorption in the femur in mechanical failure of cemented total hip arthroplasties. , 1983, Acta orthopaedica Scandinavica.

[6]  J. Galante,et al.  Bone resorption activity of particulate‐stimulated macrophages , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[7]  M. Semlitsch,et al.  Reactions of the articular capsule to wear products of artificial joint prostheses. , 1977, Journal of biomedical materials research.

[8]  I. Paul,et al.  On the origins of high in vivo wear rates in polyethylene components of total joint prostheses. , 1979, Clinical orthopaedics and related research.

[9]  I C Clarke,et al.  Mechanism and clinical significance of wear debris-induced osteolysis. , 1992, Clinical orthopaedics and related research.

[10]  N. Blumenthal,et al.  Inhibition of apatite formation by titanium and vanadium ions. , 1989, Journal of biomedical materials research.

[11]  D. Howie.  Tissue response in relation to type of wear particles around failed hip arthroplasties. , 1990, The Journal of arthroplasty.

[12]  S. Goodman,et al.  The histological effects of the implantation of different sizes of polyethylene particles in the rabbit tibia. , 1990, Journal of biomedical materials research.

[13]  I. Paul,et al.  Wear mechanisms for ultrahigh molecular weight polyethylene in the total hip prosthesis , 1979 .

[14]  E. Salvati,et al.  Size of metallic and polyethylene debris particles in failed cemented total hip replacements. , 1992, The Journal of bone and joint surgery. British volume.

[15]  J CHARNLEY,et al.  Anchorage of the femoral head prosthesis to the shaft of the femur. , 1960, The Journal of bone and joint surgery. British volume.

[16]  H. D. Leigh,et al.  Research and development report: Production of fine particulate ultra high molecular weight poly(ethylene) for biological response studies , 1992 .

[17]  C. Tarabusi,et al.  The effect of injection of powdered biomaterials on mouse peritoneal cell populations. , 1987, Journal of biomedical materials research.

[18]  J. Galante,et al.  Macrophage/particle interactions: effect of size, composition and surface area. , 1994, Journal of biomedical materials research.

[19]  J. Witt,et al.  Metal wear and tissue response in failed titanium alloy total hip replacements. , 1991, The Journal of bone and joint surgery. British volume.

[20]  M. Postel,et al.  Histological patterns of bone and articular tissues after orthopaedic reconstructive surgery (artificial joint implants). , 1991, Pathology, research and practice.

[21]  H. D. Huddleston.  Femoral lysis after cemented hip arthroplasty. , 1988, The Journal of arthroplasty.

[22]  J. Galante,et al.  Metallosis associated with a stable titanium-alloy femoral component in total hip replacement. A case report. , 1990, The Journal of bone and joint surgery. American volume.

[23]  D. Howie,et al.  A rat model of resorption of bone at the cement-bone interface in the presence of polyethylene wear particles. , 1988, The Journal of bone and joint surgery. American volume.