Skin ulcer healing enhanced by brain-derived endothelial cell growth factors

Method In this study, self-controlled skin ulcers served as the control (self-control design), so the observed objects were selected from the patients with two or more skin ulcers. The ulcers due to special infection or malignant tumours were not included. Fourteen patients with three kinds of skin ulcers, varicose, decubitus and vasculitis, were observed. There were six males and eight females with an age range of 18-71 and a mean age of 44.8. The total number of skin ulcers was 42. The time taken for the ulcers to heal was carefully monitored and their area and depth precisely measured. The mean healing time, area and depth of ulcers between the ECGF group and the control group did not differ significantly (Table 1).