The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog.

[1]  Xinhua Lin,et al.  Functions of heparan sulfate proteoglycans in cell signaling during development , 2004, Development.

[2]  S. Selleck,et al.  Spatial regulation of Wingless morphogen distribution and signaling by Dally-like protein. , 2004, Developmental cell.

[3]  Antonio J Giraldez,et al.  Opposing activities of Dally-like glypican at high and low levels of Wingless morphogen activity. , 2004, Developmental cell.

[4]  G. Rubin,et al.  The BDGP Gene Disruption Project , 2004, Genetics.

[5]  Isabel Guerrero,et al.  Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction , 2004, Development.

[6]  S. Selleck,et al.  Abrogation of heparan sulfate synthesis in Drosophila disrupts the Wingless, Hedgehog and Decapentaplegic signaling pathways , 2004, Development.

[7]  Xinhua Lin,et al.  Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation , 2004, Development.

[8]  Tetsuya Tabata,et al.  Morphogens, their identification and regulation , 2004, Development.

[9]  T. Belenkaya,et al.  Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process , 2004, Development.

[10]  Tetsuya Tabata,et al.  Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans , 2004, Development.

[11]  B. Sanson,et al.  The glypican Dally-like is required for Hedgehog signalling in the embryonic epidermis of Drosophila , 2003, Development.

[12]  T. Matsuo,et al.  Dally regulates Dpp morphogen gradient formation in the Drosophila wing , 2003, Development.

[13]  John B. Thomas,et al.  Wnt-mediated axon guidance via the Drosophila Derailed receptor , 2003, Nature.

[14]  Lawrence Lum,et al.  Identification of Hedgehog Pathway Components by RNAi in Drosophila Cultured Cells , 2003, Science.

[15]  L. Ruel,et al.  Cholesterol modification of hedgehog is required for trafficking and movement, revealing an asymmetric cellular response to hedgehog. , 2003, Developmental cell.

[16]  K. Basler,et al.  Wingful, an extracellular feedback inhibitor of Wingless. , 2002, Genes & development.

[17]  R. Copley,et al.  HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient. , 2002, Developmental cell.

[18]  N. Perrimon,et al.  Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling. , 2002, Development.

[19]  K. Amanai,et al.  Distinct roles of Central missing and Dispatched in sending the Hedgehog signal. , 2001, Development.

[20]  P. Ingham,et al.  Hedgehog signaling in animal development: paradigms and principles. , 2001, Genes & development.

[21]  P. Beachy,et al.  Skinny Hedgehog, an Acyltransferase Required for Palmitoylation and Activity of the Hedgehog Signal , 2001, Science.

[22]  J. Treisman,et al.  Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein , 2001, Current Biology.

[23]  N. Perrimon,et al.  Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless. , 2001, Development.

[24]  S. Munro,et al.  The Notch signalling regulator Fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DxD , 2000, Current Biology.

[25]  P. Beachy,et al.  Genetics of ventral forebrain development and holoprosencephaly. , 2000, Current opinion in genetics & development.

[26]  E. Hafen,et al.  Dispatched, a Novel Sterol-Sensing Domain Protein Dedicated to the Release of Cholesterol-Modified Hedgehog from Signaling Cells , 1999, Cell.

[27]  N. Perrimon,et al.  Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan. , 1999, Molecular cell.

[28]  N. Perrimon,et al.  Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling , 1999, Nature.

[29]  S. Selleck,et al.  The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila , 1999, Nature.

[30]  Alain Vincent,et al.  The COE transcription factor Collier is a mediator of short-range Hedgehog-induced patterning of the Drosophila wing , 1999, Current Biology.

[31]  D. Montell,et al.  A Drosophila derailed homolog, doughnut, expressed in invaginating cells during embryogenesis. , 1999, Gene.

[32]  J. Nathans,et al.  A new secreted protein that binds to Wnt proteins and inhibits their activites , 1999, Nature.

[33]  U. Gaul,et al.  Activation of the Drosophila C3G leads to cell fate changes and overproliferation during development, mediated by the RAS–MAPK pathway and RAP1 , 1999, The EMBO journal.

[34]  John B. Thomas,et al.  Embryonic expression and activity of doughnut, a second RYK homolog in Drosophila , 1998, Mechanisms of Development.

[35]  N. Perrimon,et al.  Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion , 1998, Nature.

[36]  C. Ambrose,et al.  Identification of a Palmitic Acid-modified Form of Human Sonic hedgehog* , 1998, The Journal of Biological Chemistry.

[37]  S. Selleck,et al.  dally, a Drosophila glypican, controls cellular responses to the TGF-beta-related morphogen, Dpp. , 1997, Development.

[38]  N. Perrimon,et al.  The Drosophila sugarless gene modulates Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis. , 1997, Development.

[39]  W. A. Johnson,et al.  Genetic evidence that heparin-like glycosaminoglycans are involved in wingless signaling. , 1997, Development.

[40]  J. Mullor,et al.  Hedgehog activity, independent of decapentaplegic, participates in wing disc patterning. , 1997, Development.

[41]  G. Struhl,et al.  Dual Roles for Patched in Sequestering and Transducing Hedgehog , 1996, Cell.

[42]  Eugene V Koonin,et al.  Hedgehog Patterning Activity: Role of a Lipophilic Modification Mediated by the Carboxy-Terminal Autoprocessing Domain , 1996, Cell.

[43]  G. Struhl,et al.  Direct and Long-Range Action of a DPP Morphogen Gradient , 1996, Cell.

[44]  Isabel Guerrero,et al.  The fu gene discriminates between pathways to control dpp expression in Drosophila imaginal discs , 1996, Mechanisms of Development.

[45]  T. Tully,et al.  Molecular cloning of linotte in Drosophila: A novel gene that functions in adults during associative learning , 1995, Neuron.

[46]  T. Préat,et al.  The Drosophila learning and memory gene linotte encodes a putative receptor tyrosine kinase homologous to the human RYK gene product , 1995, FEBS letters.

[47]  E. Knust,et al.  Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of drosophila , 1995, Cell.

[48]  C. K. Motzny,et al.  The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways , 1995, Mechanisms of Development.

[49]  Stephen C. Ekker,et al.  The product of hedgehog autoproteolytic cleavage active in local and long-range signalling , 1995, Nature.

[50]  I. Guerrero,et al.  Subcellular localization of the segment polarity protein patched suggests an interaction with the wingless reception complex in Drosophila embryos. , 1994, Development.

[51]  E. Sánchez-Herrero,et al.  The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development. , 1994, The EMBO journal.

[52]  T. Tabata,et al.  The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation. , 1992, Genes & development.

[53]  P. Beachy,et al.  Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog , 1992, Cell.

[54]  D. Lindsley,et al.  The Genome of Drosophila Melanogaster , 1992 .

[55]  W. Gelbart,et al.  An extensive 3' cis-regulatory region directs the imaginal disk expression of decapentaplegic, a member of the TGF-beta family in Drosophila. , 1991, Development.

[56]  A. Garcı́a-Bellido,et al.  Behaviour of cells mutant for an EGF receptor homologue of Drosophila in genetic mosaics , 1990, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[57]  N. Patel,et al.  Expression of engrailed during segmentation in grasshopper and crayfish. , 1989, Development.

[58]  D. Tautz,et al.  A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback , 1989, Chromosoma.

[59]  I. Beltrán Análisis genético del metamerismo en el sistema nervioso embrionario de "Drosophila" , 1988 .

[60]  G. Morata,et al.  Developmental compartmentalisation of the wing disk of Drosophila. , 1973, Nature: New biology.

[61]  Andrew P McMahon,et al.  Developmental roles and clinical significance of hedgehog signaling. , 2003, Current topics in developmental biology.

[62]  Caroline Joyce,et al.  Quantitative RT-PCR. A review of current methodologies. , 2002, Methods in molecular biology.