Isotypic pattern of the polyclonal B cell response during primary infection by Plasmodium chabaudi and in immune‐protected mice

The primary infection by P. chabaudi induces an increase of the numbers of splenic immunoglobulin (Ig)‐secreting B cells in both athymic and euthymic BALB/c mice. The isotypic pattern of the polyclonal response is restricted only in euthymic mice where IgG2a, IgG2b and IgM plaque‐forming cells (PFC) predominate. In immunized animals, protected against a parasite challenge, the isotypic pattern of splenic PFC is completely different, the IgG1 and IgM isotypes constituting the main part of the response. Reinoculation of immune‐protected animals induces a PFC response which is dose dependent and accentuates the characteristic isotypic profile of the immune‐protected mice.

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