Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas

[1]  T. Furukawa,et al.  Abrogation of DUSP6 by hypermethylation in human pancreatic cancer , 2005, Journal of Human Genetics.

[2]  Michio Shimizu,et al.  An Illustrated Consensus on the Classification of Pancreatic Intraepithelial Neoplasia and Intraductal Papillary Mucinous Neoplasms , 2004, The American journal of surgical pathology.

[3]  Olca Basturk,et al.  Pathologically and Biologically Distinct Types of Epithelium in Intraductal Papillary Mucinous Neoplasms: Delineation of an “Intestinal” Pathway of Carcinogenesis in the Pancreas , 2004, The American journal of surgical pathology.

[4]  S. Maegawa,et al.  A role for MKP3 in axial patterning of the zebrafish embryo , 2004, Development.

[5]  T. Furukawa,et al.  Molecular Pathology of Pancreatic Cancer: In Quest of Tumor Suppressor Genes , 2004, Pancreas.

[6]  F. Motoi,et al.  Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells , 2003, Oncogene.

[7]  J. Cameron,et al.  Multicomponent Analysis of the Pancreatic Adenocarcinoma Progression Model Using a Pancreatic Intraepithelial Neoplasia Tissue Microarray , 2003, Modern Pathology.

[8]  F. Motoi,et al.  Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer. , 2003, The American journal of pathology.

[9]  J. C. Belmonte,et al.  MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb , 2003, Nature Cell Biology.

[10]  F. Sarkar,et al.  The Dichotomy in the Preinvasive Neoplasia to Invasive Carcinoma Sequence in the Pancreas: Differential Expression of MUC1 and MUC2 Supports the Existence of Two Separate Pathways of Carcinogenesis , 2002, Modern Pathology.

[11]  R H Hruban,et al.  Pancreatic Intraepithelial Neoplasia: A New Nomenclature and Classification System for Pancreatic Duct Lesions , 2001, The American journal of surgical pathology.

[12]  J. Cameron,et al.  Dpc-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas: comparison with conventional ductal adenocarcinomas. , 2000, The American journal of pathology.

[13]  H. Kijima,et al.  Not hMSH2 but hMLH1 is frequently silenced by hypermethylation in endometrial cancer but rarely silenced in pancreatic cancer with microsatellite instability. , 2000, International journal of oncology.

[14]  R H Hruban,et al.  Progression model for pancreatic cancer. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

[15]  T. Furukawa,et al.  Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma , 2000, American Journal of Gastroenterology.

[16]  R. Hruban,et al.  Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression. , 2000, Cancer research.

[17]  E. Soeda,et al.  Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer , 1998, Cytogenetic and Genome Research.

[18]  R. Hruban,et al.  Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: loss of intranuclear expression. , 1998, Cancer research.

[19]  T. Ono,et al.  Infrequent Genetic Alterations of the PTEN/MMAC1 Gene in Japanese Patients with Primary Cancers of the Breast, Lung, Pancreas, Kidney, and Ovary , 1997, Japanese journal of cancer research : Gann.

[20]  F. Waldman,et al.  Frequent gain of copy number on the long arm of chromosome 20 in human pancreatic adenocarcinoma , 1997, Genes, chromosomes & cancer.

[21]  S. Goodman,et al.  Tumor-suppressive pathways in pancreatic carcinoma. , 1997, Cancer research.

[22]  A. Horii,et al.  Alternative splicing of hMSH2 in normal human tissues , 1997, Human Genetics.

[23]  A. Horii,et al.  Detailed deletion mapping on chromosome arm 12q in human pancreatic adenocarcinoma: Identification of a 1‐cM region of common allelic loss , 1996, Genes, chromosomes & cancer.

[24]  D. Alessi,et al.  Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual‐specificity phosphatase. , 1996, The EMBO journal.

[25]  M. Muda,et al.  MKP-3, a Novel Cytosolic Protein-tyrosine Phosphatase That Exemplifies a New Class of Mitogen-activated Protein Kinase Phosphatase (*) , 1996, The Journal of Biological Chemistry.

[26]  Scott E. Kern,et al.  DPC4, A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1 , 1996, Science.

[27]  R. Hruban,et al.  Allelotype of pancreatic adenocarcinoma using xenograft enrichment. , 1995, Cancer research.

[28]  R. Hruban,et al.  Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma , 1994, Nature Genetics.

[29]  R. Hruban,et al.  p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions. , 1994, Cancer research.

[30]  H. Nagura,et al.  Varying grades of epithelial atypia in the pancreatic ducts of humans. Classification based on morphometry and multivariate analysis and correlated with positive reactions of carcinoembryonic antigen. , 1994, Archives of pathology & laboratory medicine.

[31]  T. Takahashi,et al.  The mucus‐hypersecreting tumor of the pancreas. Development and extension visualized by three‐dimensional computerized mapping , 1992, Cancer.

[32]  S. Saga,et al.  Relation of pancreatic duct hyperplasia to carcinoma , 1979, Cancer.

[33]  A. Cubilla,et al.  Morphological lesions associated with human primary invasive nonendocrine pancreas cancer. , 1976, Cancer research.

[34]  S. Sommers,et al.  Pancreatic duct hyperplasia and cancer. , 1954, Gastroenterology.

[35]  H. Kijima,et al.  Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines. , 2001, Oncology reports.

[36]  R. Hruban,et al.  Molecular pathology of pancreatic cancer. , 2001, Cancer journal.

[37]  S. Belinsky,et al.  Detection and quantitation of mutant K-ras codon 12 restriction fragments by capillary electrophoresis. , 1995, Analytical biochemistry.

[38]  J. Bos,et al.  A dot-blot screening procedure for mutated ras oncogenes using synthetic oligodeoxynucleotides. , 1986, Gene.

[39]  K. Ohhashi.  Four cases of mucin-producing cancer of the pancreas on specific findings of the papilla of Vater , 1982 .