Asymmetric dimethyl arginine induces pulmonary vascular dysfunction via activation of signal transducer and activator of transcription 3 and stabilization of hypoxia-inducible factor 1-alpha.

[1]  H. Seyfarth,et al.  Die angiogenetischen Faktoren VEGF, Angiogenin und bFGF im Atemkondensat von Patienten mit pulmonaler Hypertonie , 2015, Pneumologie.

[2]  D. Sedding,et al.  Emerging translational approaches to target STAT3 signalling and its impact on vascular disease , 2015, Cardiovascular research.

[3]  M. Klebanoff,et al.  Plasma asymmetric dimethylarginine levels are increased in neonates with bronchopulmonary dysplasia-associated pulmonary hypertension. , 2015, The Journal of pediatrics.

[4]  Cheuk-Kwan Sun,et al.  Reducing TRPC1 Expression through Liposome-Mediated siRNA Delivery Markedly Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension in a Murine Model , 2014, Stem cells international.

[5]  Mingyu Liang,et al.  miR-21 in ischemia/reperfusion injury: a double-edged sword? , 2014, Physiological genomics.

[6]  Lan Zhao,et al.  miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia. , 2014, The Biochemical journal.

[7]  L. Nelin,et al.  Asymmetric dimethylarginine does not inhibit arginase activity and is pro‐proliferative in pulmonary endothelial cells , 2014, Clinical and experimental pharmacology & physiology.

[8]  S. Rosenkranz,et al.  Protective effects of 10-nitro-oleic acid in a hypoxia-induced murine model of pulmonary hypertension. , 2014, American journal of respiratory cell and molecular biology.

[9]  F. Potus,et al.  Vascular Remodeling Process in Pulmonary Arterial Hypertension, with Focus on miR-204 and miR-126 (2013 Grover Conference Series) , 2014, Pulmonary circulation.

[10]  Joyce D. Schroeder,et al.  Cystatin C: A potential biomarker for pulmonary arterial hypertension , 2014, Respirology.

[11]  S. Richard,et al.  Transcriptional repression of hypoxia-inducible factor-1 (HIF-1) by the protein arginine methyltransferase PRMT1 , 2014, Molecular biology of the cell.

[12]  L. Harbaum,et al.  The Endothelial ADMA/NO Pathway in Hypoxia-Related Chronic Respiratory Diseases , 2014, BioMed research international.

[13]  Jeffrey N. Martin,et al.  Increased levels of asymmetric dimethylarginine are associated with pulmonary arterial hypertension in HIV infection , 2014, AIDS.

[14]  T. Gudermann,et al.  Classical transient receptor potential channel 1 in hypoxia-induced pulmonary hypertension. , 2013, American journal of respiratory and critical care medicine.

[15]  A. Lojek,et al.  Asymmetric dimethylarginine regulates the lipopolysaccharide-induced nitric oxide production in macrophages by suppressing the activation of NF-kappaB and iNOS expression. , 2013, European journal of pharmacology.

[16]  G. Semenza,et al.  Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1. , 2013, American journal of physiology. Lung cellular and molecular physiology.

[17]  Min-Seon Kim,et al.  Vaspin Increases Nitric Oxide Bioavailability through the Reduction of Asymmetric Dimethylarginine in Vascular Endothelial Cells , 2012, PloS one.

[18]  R. Rafikov,et al.  Asymmetric Dimethylarginine Induces Endothelial Nitric-oxide Synthase Mitochondrial Redistribution through the Nitration-mediated Activation of Akt1* , 2012, The Journal of Biological Chemistry.

[19]  A. Lojek,et al.  The unique role of dietary l-arginine in the acceleration of peritoneal macrophage sensitivity to bacterial endotoxin , 2012, Immunologic Research.

[20]  R. Wolfe,et al.  Arginine de novo and nitric oxide production in disease states. , 2012, American journal of physiology. Endocrinology and metabolism.

[21]  S. Bonnet,et al.  STAT3 signaling in pulmonary arterial hypertension , 2012, JAK-STAT.

[22]  K. Preissner,et al.  Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders , 2012, International journal of molecular sciences.

[23]  S. Chan,et al.  Hypoxamirs in Pulmonary Hypertension: Breathing New Life into Pulmonary Vascular Research. , 2012, Cardiovascular diagnosis and therapy.

[24]  D. Tsikas,et al.  Increased asymmetric dimethylarginine (ADMA) dimethylaminohydrolase (DDAH) activity in childhood hypercholesterolemia type II , 2012, Amino Acids.

[25]  H. Fung,et al.  Mechanism of Cellular Oxidation Stress Induced by Asymmetric Dimethylarginine , 2012, International journal of molecular sciences.

[26]  Y. Mori,et al.  TRP channels: sensors and transducers of gasotransmitter signals , 2012, Front. Physio..

[27]  Ayhan Cevik,et al.  Elevated Homocysteine and Asymmetric Dimethyl Arginine Levels in Pulmonary Hypertension Associated With Congenital Heart Disease , 2012, Pediatric Cardiology.

[28]  S. Blankenberg,et al.  Pathogenic Cycle Between the Endogenous Nitric Oxide Synthase Inhibitor Asymmetrical Dimethylarginine and the Leukocyte-Derived Hemoprotein Myeloperoxidase , 2011, Circulation.

[29]  C. Ducsay,et al.  eNOS activation and NO function: differential control of steroidogenesis by nitric oxide and its adaptation with hypoxia. , 2011, The Journal of endocrinology.

[30]  Zhang Dong-liang,et al.  Actin cytoskeleton modulates ADMA-induced NF-kappaB nuclear translocation and ICAM-1 expression in endothelial cells , 2011, Medical science monitor : international medical journal of experimental and clinical research.

[31]  V. Salemi,et al.  Pulmonary hypertension diagnosed by right heart catheterisation in sickle cell disease , 2011, European Respiratory Journal.

[32]  P. Tsao,et al.  Asymmetric dimethylarginine impairs fibrinolytic activity in human umbilical vein endothelial cells via p38 MAPK and NF-κB pathways. , 2011, Thrombosis research.

[33]  H. Ghofrani,et al.  Mechanisms of disease: pulmonary arterial hypertension , 2011, Nature Reviews Cardiology.

[34]  B. Sarkadi,et al.  ABC transporters affect the detection of intracellular oxidants by fluorescent probes , 2011, Free radical research.

[35]  M. Muckenthaler,et al.  Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart: a key role for ubiquitin-conjugating enzymes. , 2011, European heart journal.

[36]  G. Semenza,et al.  Hypoxia-inducible factor plays a gut-injurious role in intestinal ischemia reperfusion injury. , 2011, American journal of physiology. Gastrointestinal and liver physiology.

[37]  B. Jiang,et al.  MiR-21 Induced Angiogenesis through AKT and ERK Activation and HIF-1α Expression , 2011, PloS one.

[38]  Wei-Hua Wu,et al.  Involvement of asymmetric dimethylarginine and Rho kinase in the vascular remodeling in monocrotaline-induced pulmonary hypertension. , 2010, Vascular pharmacology.

[39]  M. Gladwin,et al.  Pulmonary hypertension in hemolytic disorders: pulmonary vascular disease: the global perspective. , 2010, Chest.

[40]  R. Vasan,et al.  Review article: Asymmetric dimethylarginine as a mediator of vascular dysfunction and a marker of cardiovascular disease and mortality: an intriguing interaction with diabetes mellitus , 2010, Diabetes & vascular disease research.

[41]  A. Cardounel,et al.  Role of the PRMT-DDAH-ADMA axis in the regulation of endothelial nitric oxide production. , 2009, Pharmacological research.

[42]  C. Metz,et al.  Cholinergic agonists regulate JAK2/STAT3 signaling to suppress endothelial cell activation. , 2009, American journal of physiology. Cell physiology.

[43]  Dimitris Tousoulis,et al.  Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis. , 2009, European heart journal.

[44]  J. Zweier,et al.  Regulation of eNOS-derived superoxide by endogenous methylarginines. , 2008, Biochemistry.

[45]  S. Black,et al.  Asymmetric dimethylarginine inhibits HSP90 activity in pulmonary arterial endothelial cells: role of mitochondrial dysfunction. , 2008, American journal of physiology. Cell physiology.

[46]  J. McMurray,et al.  An epidemiological study of pulmonary arterial hypertension , 2007, European Respiratory Journal.

[47]  A. Holian,et al.  Asymmetric dimethylarginine induces oxidative and nitrosative stress in murine lung epithelial cells. , 2007, American journal of respiratory cell and molecular biology.

[48]  P. Vallance,et al.  The ADMA/DDAH pathway is a critical regulator of endothelial cell motility , 2007, Journal of Cell Science.

[49]  A. Koller,et al.  Asymmetrical Dimethylarginine Inhibits Shear Stress–Induced Nitric Oxide Release and Dilation and Elicits Superoxide-Mediated Increase in Arteriolar Tone , 2007, Hypertension.

[50]  C. Lowenstein,et al.  Stat3 Mediates Interelukin-6 Inhibition of Human Endothelial Nitric-oxide Synthase Expression* , 2006, Journal of Biological Chemistry.

[51]  M. Humbert,et al.  Early detection of pulmonary arterial hypertension in systemic sclerosis: a French nationwide prospective multicenter study. , 2005, Arthritis and rheumatism.

[52]  L. Becker,et al.  Signal Transducer and Activator of Transcription 3α and Specificity Protein 1 Interact to Upregulate Intercellular Adhesion Molecule-1 in Ischemic–Reperfused Myocardium and Vascular Endothelium , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[53]  W. Seeger,et al.  Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[54]  V. Poli,et al.  A Role of STAT3 in Rho GTPase-regulated Cell Migration and Proliferation* , 2005, Journal of Biological Chemistry.

[55]  A. Malik,et al.  Tumor necrosis factor-alpha-induced TRPC1 expression amplifies store-operated Ca2+ influx and endothelial permeability. , 2004, American journal of physiology. Lung cellular and molecular physiology.

[56]  C. Tse,et al.  Chronic Hypoxia–Induced Upregulation of Store-Operated and Receptor-Operated Ca2 Channels in Pulmonary Arterial Smooth Muscle Cells: A Novel Mechanism of Hypoxic Pulmonary Hypertension , 2004, Circulation research.

[57]  C. Denton,et al.  Prevalence and outcome in systemic sclerosis associated pulmonary arterial hypertension: application of a registry approach , 2003, Annals of the rheumatic diseases.

[58]  H. Foda,et al.  Mechanical stretch induces MMP-2 release and activation in lung endothelium: role of EMMPRIN. , 2003, American journal of physiology. Lung cellular and molecular physiology.

[59]  Ying Yu,et al.  PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression. , 2003, American journal of physiology. Cell physiology.

[60]  C. Cooper,et al.  Nitric oxide synthases: structure, function and inhibition. , 2001, The Biochemical journal.

[61]  B. Mayer,et al.  Enzymatic function of nitric oxide synthases. , 1999, Cardiovascular research.

[62]  B. Mayer,et al.  Biosynthesis and action of nitric oxide in mammalian cells. , 1997, Trends in biochemical sciences.

[63]  S. Watson,et al.  Asymmetric dimethylarginine and whole blood viscosity in renal failure. , 2015, Clinical hemorheology and microcirculation.

[64]  R. Mathew.  Pathogenesis of pulmonary hypertension: a case for caveolin-1 and cell membrane integrity. , 2014, American journal of physiology. Heart and circulatory physiology.

[65]  L. Kubala,et al.  The effect of different molecular weight hyaluronan on macrophage physiology. , 2009, Neuro endocrinology letters.

[66]  T. Renné,et al.  Modulation of Rac1 activity by ADMA/DDAH regulates pulmonary endothelial barrier function. , 2009, Molecular biology of the cell.

[67]  G. Simonneau,et al.  Prevalence of HIV-related pulmonary arterial hypertension in the current antiretroviral therapy era. , 2008, American journal of respiratory and critical care medicine.

[68]  M. Pozo,et al.  Calcium controls smooth muscle TRPC gene transcription via the CaMK/calcineurin-dependent pathways. , 2007, American journal of physiology. Cell physiology.

[69]  C. Lowenstein,et al.  Stat3 mediates interleukin-6 [correction of interelukin-6] inhibition of human endothelial nitric-oxide synthase expression. , 2006, The Journal of biological chemistry.

[70]  D. Tsikas,et al.  ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitamins. , 2003, Cardiovascular research.

[71]  H. Patel,et al.  O R I G I N a L I N V E S T I G a T I O N Open Access Hyperglycemia Induces Differential Change in Oxidative Stress at Gene Expression and Functional Levels in Huvec and Hmvec , 2022 .