Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

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Schurmann | H. Grabe | A. Teumer | U. Völker | S. Medland | J. Dennis | S. F. Nielsen | J. Tyrer | K. North | J. Corley | A. Franke | G. Peloso | D. Saleheen | James G. Wilson | P. Njølstad | J. van Setten | J. Kooner | E. Bottinger | I. Barroso | J. Howson | N. Robertson | G. Davies | C. Hayward | S. Kanoni | O. Polašek | V. Vitart | Wei Zhao | G. Dedoussis | J. Faul | M. Kähönen | H. Vestergaard | E. Larson | M. Feitosa | T. Winkler | X. Sim | A. Manning | P. Komulainen | J. Luan | S. Padmanabhan | A. Robino | R. Scott | T. V. Varga | E. Ware | H. Warren | Weihua Zhang | M. Brumat | E. Evangelou | I. Gandin | J. Kuusisto | C. Langenberg | N. Palmer | P. Schreiner | D. Bowden | J. Chambers | P. Gasparini | L. Wagenknecht | D. Mook-Kanamori | A. Slater | G. Jarvik | K. Harris | C. Have | J. Bork-Jensen | Wei Zhou | M. Dubé | R. Loos | R. Varma | S. Vedantam | Ching‐Ti Liu | O. Holmen | S. Sivapalaratnam | A. Wood | S. Männistö | C. Palmer | L. Lyytikäinen | Ying Wu | Eric S. Kim | J. 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Edwards | Aliki-Eleni Farmaki | Shuang Feng | R. Frikke-Schmidt | W. Gan | A. Giri | M. Gorski | M. Grove | Liang He | Ø. Helgeland | J. Hernesniemi | A. Hewitt | Paul L. Huang | J. Jansson | G. Jensen | Yucheng Jia | S. Johansson | M. Jørgensen | P. R. Kamstrup | Maria Karaleftheri | F. Karpe | H. Kitajima | H. Kuivaniemi | L. Lange | Jin Li | R. Li-Gao | Honghuang Lin | Li-An Lin | A. Mazul | K. Meidtner | M. Neville | K. Nikus | J. O'Connel | C. Packard | A. Patel | C. Pennell | J. Perry | T. Person | Ailith Pirie | A. Rasheed | F. Renström | O. Rolandsson | K. Ruth | Y. Sapkota | L. Southam | P. Surendran | G. Tromp | E. Tsafantakis | A. Tybjaerg-hansen | T. Vogt | Feijie Wang | Carol A. Wang | Shuai Wang | Yiqin Wang | J. Wessel | D. Witte | H. Yaghootkar | P. Yao | L. Yerges-Armstrong | R. Young | A. Gjesing | I. Farooqi | T. Polderman | S. W. Laan | N. Lee | H. Ruijter | T. Korhonen | R. Mckean-Cowdin | M. Vanhala | S. Fauser | D. Roberts | L. O. Olde Loohuis | Trevor A. 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Gibson | Mengmeng Du | R. Scott | Ying Wu | T. Hansen | A. Peters | A. Jackson | K. Taylor | M. McCarthy | R. Mckean‐Cowdin | Wei Zhao | H. M. Ruijter | A. Pirie | Angela D'eustacchio | C. Palmer | G. Davies | K. Taylor | G. K. Hovingh | A. Peters | A. Morris | P. Kamstrup

[1]  T. Pellinen,et al.  Small GTPase Rab 21 regulates cell adhesion and controls endosomal traffi c of β 1-integrins , 2019 .

[2]  M. Kanai,et al.  Genome-wide association study identifies 112 new loci for body mass index in the Japanese population , 2017, Nature Genetics.

[3]  Nathan A. Bihlmeyer,et al.  SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. , 2017, Journal of the American Society of Nephrology : JASN.

[4]  He Gao,et al.  Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk , 2017, Nature Genetics.

[5]  Marcelo P. Segura-Lepe,et al.  Rare and low-frequency coding variants alter human adult height , 2016, Nature.

[6]  Claude Bouchard,et al.  Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci , 2016, Nature Genetics.

[7]  He Zhang,et al.  Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension , 2016, Nature Genetics.

[8]  Stephen C. J. Parker,et al.  The genetic architecture of type 2 diabetes , 2016, Nature.

[9]  K. Clément,et al.  Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist. , 2016, The New England journal of medicine.

[10]  He Gao,et al.  Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits. , 2016, American journal of human genetics.

[11]  Xiaodong Cheng,et al.  Role of Exchange Protein Directly Activated by Cyclic AMP Isoform 1 in Energy Homeostasis: Regulation of Leptin Expression and Secretion in White Adipose Tissue , 2016, Molecular and Cellular Biology.

[12]  M. Tena-Sempere,et al.  Hypothalamic AMPK: a canonical regulator of whole-body energy balance , 2016, Nature Reviews Endocrinology.

[13]  P. Nolan,et al.  The Zfhx3-Mediated Axis Regulates Sleep and Interval Timing in Mice , 2016, Cell reports.

[14]  D. Storm,et al.  Hypomorphism of Fto and Rpgrip1l causes obesity in mice. , 2016, The Journal of clinical investigation.

[15]  M. Tschöp,et al.  Reappraisal of GIP Pharmacology for Metabolic Diseases. , 2016, Trends in molecular medicine.

[16]  Xiaowei Zhan,et al.  RVTESTS: an efficient and comprehensive tool for rare variant association analysis using sequence data , 2016, Bioinform..

[17]  A. Reiner,et al.  The effect of phenotypic outliers and non-normality on rare-variant association testing , 2016, European Journal of Human Genetics.

[18]  James Y. Zou.  Analysis of protein-coding genetic variation in 60,706 humans , 2015, Nature.

[19]  Tanya M. Teslovich,et al.  The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study , 2015, PLoS Genetics.

[20]  Manolis Kellis,et al.  FTO Obesity Variant Circuitry and Adipocyte Browning in Humans. , 2015, The New England journal of medicine.

[21]  J. Zierath,et al.  Skeletal muscle AMP-activated protein kinase γ1(H151R) overexpression enhances whole body energy homeostasis and insulin sensitivity. , 2015, American journal of physiology. Endocrinology and metabolism.

[22]  Blair H. Smith,et al.  Generation Scotland , 2015 .

[23]  A. Mallon,et al.  The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis , 2015, Cell.

[24]  Xiaodong Cheng,et al.  Exchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeutics , 2015, Gene.

[25]  Jun S. Liu,et al.  The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans , 2015, Science.

[26]  Oksana Gavrilova,et al.  A neural basis for melanocortin-4 receptor regulated appetite , 2015, Nature Neuroscience.

[27]  Thomas D. Dyer,et al.  Transcriptomic Identification of ADH1B as a Novel Candidate Gene for Obesity and Insulin Resistance in Human Adipose Tissue in Mexican Americans from the Veterans Administration Genetic Epidemiology Study (VAGES) , 2015, PloS one.

[28]  I. Farooqi,et al.  The Hunger Genes: Pathways to Obesity , 2015, Cell.

[29]  Ross M. Fraser,et al.  Genetic studies of body mass index yield new insights for obesity biology , 2015, Nature.

[30]  Florian Kronenberg,et al.  EasyStrata: evaluation and visualization of stratified genome-wide association meta-analysis data , 2015, Bioinform..

[31]  Y. J. Kim,et al.  Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. , 2014, Human molecular genetics.

[32]  P. Fischer-Posovszky,et al.  Comparative gene array analysis of progenitor cells from human paired deep neck and subcutaneous adipose tissue , 2014, Molecular and Cellular Endocrinology.

[33]  F. Villarroya,et al.  GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK , 2014, Diabetes.

[34]  Shuang Feng,et al.  RAREMETAL: fast and powerful meta-analysis for rare variants , 2014, Bioinform..

[35]  W. Chung,et al.  Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice. , 2014, Cell metabolism.

[36]  H. Frierson,et al.  Deletion of Atbf1/Zfhx3 In Mouse Prostate Causes Neoplastic Lesions, Likely by Attenuation of Membrane and Secretory Proteins and Multiple Signaling Pathways , 2014, Neoplasia.

[37]  Zoltán Kutalik,et al.  Quality control and conduct of genome-wide association meta-analyses , 2014, Nature Protocols.

[38]  G. Bray,et al.  Update on obesity pharmacotherapy , 2014, Annals of the New York Academy of Sciences.

[39]  N. Cox,et al.  Obesity-associated variants within FTO form long-range functional connections with IRX3 , 2014, Nature.

[40]  D. Hardie,et al.  AMPK-and SNF 1-Related Kinases : Roles in Lower Eukaryotes , 2014 .

[41]  Differential Regulation of Lipid Metabolism Genes in the Brain of Acetylcholinesterase Knockout Mice , 2014, Journal of Molecular Neuroscience.

[42]  Eric S. Lander,et al.  A polygenic burden of rare disruptive mutations in schizophrenia , 2014, Nature.

[43]  Xiaodong Cheng,et al.  Cyclic AMP sensor EPAC proteins and energy homeostasis , 2014, Trends in Endocrinology & Metabolism.

[44]  Dajiang J. Liu,et al.  Meta-Analysis of Gene Level Tests for Rare Variant Association , 2013, Nature Genetics.

[45]  J. Macdonald,et al.  Interaction of Acetylcholinesterase with Neurexin-1β regulates Glutamatergic Synaptic stability in Hippocampal neurons , 2014, Molecular Brain.

[46]  A. Dunning,et al.  Beyond GWASs: illuminating the dark road from association to function. , 2013, American journal of human genetics.

[47]  D. Barford,et al.  KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation , 2013, Cell.

[48]  Bradley P. Coe,et al.  Formation of chimeric genes by copy-number variation as a mutational mechanism in schizophrenia. , 2013, American journal of human genetics.

[49]  J. Bos,et al.  Exchange protein activated by cAMP 1 (Epac1)‐deficient mice develop β‐cell dysfunction and metabolic syndrome , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[50]  Eric Boerwinkle,et al.  Best Practices and Joint Calling of the HumanExome BeadChip: The CHARGE Consortium , 2013, PloS one.

[51]  Xiaofeng Zhu,et al.  A Meta-Analysis Identifies New Loci Associated with Body Mass index in Individuals of African Ancestry , 2013, Nature Genetics.

[52]  M. Motamedi,et al.  Enhanced Leptin Sensitivity, Reduced Adiposity, and Improved Glucose Homeostasis in Mice Lacking Exchange Protein Directly Activated by Cyclic AMP Isoform 1 , 2012, Molecular and Cellular Biology.

[53]  Patrick F. Sullivan,et al.  zCall: a rare variant caller for array-based genotyping: Genetics and population analysis , 2012, Bioinform..

[54]  Adam Kiezun,et al.  Exome sequencing and the genetic basis of complex traits , 2012, Nature Genetics.

[55]  D. Hardie,et al.  AMPK: a nutrient and energy sensor that maintains energy homeostasis , 2012, Nature Reviews Molecular Cell Biology.

[56]  P. Tariot,et al.  Long-term safety and tolerability of donepezil 23 mg in patients with moderate to severe Alzheimer’s disease , 2012, BMC Research Notes.

[57]  Xihong Lin,et al.  Rare-variant association testing for sequencing data with the sequence kernel association test. , 2011, American journal of human genetics.

[58]  Mark I McCarthy,et al.  Genomic inflation factors under polygenic inheritance , 2011, European Journal of Human Genetics.

[59]  M. Farlow,et al.  Safety and tolerability of donepezil 23 mg in moderate to severe Alzheimer's disease , 2011, BMC neurology.

[60]  D. Powell,et al.  Profound Obesity Secondary to Hyperphagia in Mice Lacking Kinase Suppressor of Ras 2 , 2011, Obesity.

[61]  R. Adan,et al.  Melanocortin‐4 Receptor Gene Mutations in a Dutch Cohort of Obese Children , 2011, Obesity.

[62]  W. Chung,et al.  Cut-like Homeobox 1 (CUX1) Regulates Expression of the Fat Mass and Obesity-associated and Retinitis Pigmentosa GTPase Regulator-interacting Protein-1-like (RPGRIP1L) Genes and Coordinates Leptin Receptor Signaling* , 2010, The Journal of Biological Chemistry.

[63]  Y. Tao.  The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology. , 2010, Endocrine reviews.

[64]  Yun Li,et al.  METAL: fast and efficient meta-analysis of genomewide association scans , 2010, Bioinform..

[65]  P. Tariot,et al.  Effectiveness and tolerability of high-dose (23 mg/d) versus standard-dose (10 mg/d) donepezil in moderate to severe Alzheimer's disease: A 24-week, randomized, double-blind study. , 2010, Clinical therapeutics.

[66]  Marylyn D. Ritchie,et al.  PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene–disease associations , 2010, Bioinform..

[67]  Alex Doney,et al.  Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge , 2010, Nature Genetics.

[68]  Xiaodong Cheng,et al.  Epac, not PKA catalytic subunit, is required for 3T3-L1 preadipocyte differentiation. , 2010, Frontiers in bioscience.

[69]  Tanya M. Teslovich,et al.  Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index , 2010 .

[70]  Shamil R Sunyaev,et al.  Pooled association tests for rare variants in exon-resequencing studies. , 2010, American journal of human genetics.

[71]  Robert E. Lewis,et al.  KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity. , 2009, Cell metabolism.

[72]  V. Rao,et al.  Proteomic characterization of the dynamic KSR-2 interactome, a signaling scaffold complex in MAPK pathway. , 2009, Biochimica et biophysica acta.

[73]  N. Irwin,et al.  Evidence for beneficial effects of compromised gastric inhibitory polypeptide action in obesity-related diabetes and possible therapeutic implications , 2009, Diabetologia.

[74]  F. Haj,et al.  Neuronal Protein Tyrosine Phosphatase 1B Deficiency Results in Inhibition of Hypothalamic AMPK and Isoform-Specific Activation of AMPK in Peripheral Tissues , 2009, Molecular and Cellular Biology.

[75]  Ellen Kampman,et al.  Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity , 2009, Nature Genetics.

[76]  D. Powell,et al.  High‐throughput Screening of Mouse Knockout Lines Identifies True Lean and Obese Phenotypes , 2008, Obesity.

[77]  F. Fougerousse,et al.  Genetic ablation of acetylcholinesterase alters muscle function in mice. , 2008, Chemico-biological interactions.

[78]  M. Bachmann,et al.  Vaccination against GIP for the Treatment of Obesity , 2008, PloS one.

[79]  S. O’Rahilly,et al.  Prevalence of Melanocortin-4 Receptor Deficiency in Europeans and Their Age-Dependent Penetrance in Multigenerational Pedigrees , 2008, Diabetes.

[80]  Jianxin Xie,et al.  The Creb1 coactivator Crtc1 is required for energy balance and fertility , 2008, Nature Medicine.

[81]  J. Merchant,et al.  Hip1r is expressed in gastric parietal cells and is required for tubulovesicle formation and cell survival in mice. , 2008, The Journal of clinical investigation.

[82]  I. Taniuchi,et al.  Repression of the Transcription Factor Th-POK by Runx Complexes in Cytotoxic T Cell Development , 2008, Science.

[83]  F. Horber,et al.  Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene. , 2007, Human molecular genetics.

[84]  Harald Hutter,et al.  Axon guidance genes identified in a large-scale RNAi screen using the RNAi-hypersensitive Caenorhabditis elegans strain nre-1(hd20) lin-15b(hd126) , 2007, Proceedings of the National Academy of Sciences.

[85]  Tanya Hansotia,et al.  Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure. , 2007, The Journal of clinical investigation.

[86]  T. Pellinen,et al.  Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of β1-integrins , 2006, The Journal of cell biology.

[87]  K. Clément,et al.  Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating. , 2006, The Journal of clinical endocrinology and metabolism.

[88]  M. Birnbaum,et al.  AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus , 2004, Nature.

[89]  Å. Engqvist-Goldstein,et al.  RNAi-mediated Hip1R silencing results in stable association between the endocytic machinery and the actin assembly machinery. , 2004, Molecular biology of the cell.

[90]  T. Kirley,et al.  Bacterial expression, characterization, and disulfide bond determination of soluble human NTPDase6 (CD39L2) nucleotidase: implications for structure and function. , 2003, Biochemistry.

[91]  Thomas Gudermann,et al.  Melanocortin-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity. , 2003, The Journal of clinical endocrinology and metabolism.

[92]  Sheng-Cai Lin,et al.  Cidea-deficient mice have lean phenotype and are resistant to obesity , 2003, Nature Genetics.

[93]  A. Levey,et al.  Altered hippocampal muscarinic receptors in acetylcholinesterase‐deficient mice , 2003, Annals of neurology.

[94]  Tim Cheetham,et al.  Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. , 2003, The New England journal of medicine.

[95]  B. Viollet,et al.  The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity. , 2003, The Journal of clinical investigation.

[96]  Robert E. Lewis,et al.  KSR 2 Is An Essential Regulator of AMP Kinase , Energy Expenditure , and Insulin Sensitivity , 2003 .

[97]  Yuichiro Yamada,et al.  Inhibition of gastric inhibitory polypeptide signaling prevents obesity , 2002, Nature Medicine.

[98]  G. Duester,et al.  Distinct Retinoid Metabolic Functions for Alcohol Dehydrogenase Genes Adh1 and Adh4 in Protection against Vitamin A Toxicity or Deficiency Revealed in Double Null Mutant Mice* , 2002, The Journal of Biological Chemistry.

[99]  S. Woods,et al.  Central nervous system control of food intake , 2000, Nature.

[100]  K. Clément,et al.  Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. , 2000, The Journal of clinical investigation.

[101]  J. Hebebrand,et al.  Phenotypes in three pedigrees with autosomal dominant obesity caused by haploinsufficiency mutations in the melanocortin-4 receptor gene. , 1999, American journal of human genetics.

[102]  J. Hebebrand,et al.  Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans. , 1999, The Journal of clinical endocrinology and metabolism.

[103]  K. Clément,et al.  A frameshift mutation in human MC4R is associated with a dominant form of obesity , 1998, Nature Genetics.

[104]  S. O’Rahilly,et al.  A frameshift mutation in MC4R associated with dominantly inherited human obesity , 1998, Nature Genetics.

[105]  J. Korn,et al.  Cloning and characterization of hcKrox, a transcriptional regulator of extracellular matrix gene expression. , 1997, Gene.

[106]  R. Cone,et al.  Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice , 1997, Cell.

[107]  Victor J. Hruby,et al.  Role of melanocortinergic neurons in feeding and the agouti obesity syndrome , 1997, Nature.

[108]  O. Lockridge,et al.  Mutation at codon 322 in the human acetylcholinesterase (ACHE) gene accounts for YT blood group polymorphism. , 1993, American journal of human genetics.

[109]  H. Frierson,et al.  Deletion of Atbf1/Zfhx3 In Mouse Prostate Causes Neoplastic Lesions, Likely by Attenuation of Membrane and Secretory Proteins and Multiple Signaling Pathways , 2014, Neoplasia.