Sedentary behaviors and health-related quality of life . A systematic review and meta-analysis

Researchers have speculated that sedentary behavior may reduce health-related quality of life (HRQOL), but the extent to which this is true remains unknown. Our study sought to systematically review and synthesize research on the relationship of sedentary behavior and HRQOL and to investigate if these relationships are moderated by age, health status, and HRQOL domain. The review was registered with PROSPERO (no. CRD42016036342). We searched six electronic databases. The selection process resulted in including k = 27 original studies; k = 18 were included into a meta-analysis. Data were synthesized twice, using the methods of systematic review and meta-analysis, in order to reduce biases related to a small number of included studies. Both the systematic review and meta-analytical methods indicated that lower levels of sedentary behaviors were associated with higher physical HRQOL (estimate of average effect: r = -.140; 95% CI -.191,-.088). Moderator analyses indicated that associations between the physical HRQOL domain and sedentary behaviors may be similar in strength across ageand health status groups. Causal inferences could not be drawn as most studies were cross-sectional. Concluding, sedentary behaviors were related to better physical HRQOL but not reliably to mental and social HRQOL.

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