Flow Imaging and Computing: Large Artery Hemodynamics

The objective of our session at the International Bio-Fluid Mechanics Symposium and Workshop was at the International Bio-Fluid Mechanics Symponium and Workshop to review the state-of-the-art in, and identify future directions for, imaging and computational modeling of blood flow in the large arteries and the microcirculation. Naturally, talks in other sessions of the workshop overlapped this broad topic, and so here we summarize progress within the last decade in terms of the technical development and application of flow imaging and computing, rather than the knowledge derived from specific studies. We then briefly discuss ways in these tools may be extended, and their application broadened, in the next decade. Furthermore, owing to the conceptual division between the hemodynamics of large arteries, and those within the microcirculation, we review these regimes separately: The former here by Steinman and Taylor; and the latter in a separate paper by Cristini.

[1]  G. Hutchins,et al.  Correlation between intimal thickness and fluid shear in human arteries. , 1981, Atherosclerosis.

[2]  M H Friedman,et al.  Numerical simulation of aortic bifurcation flows: the effect of flow divider curvature. , 1984, Journal of biomechanics.

[3]  D. Ku,et al.  Pulsatile Flow and Atherosclerosis in the Human Carotid Bifurcation: Positive Correlation between Plaque Location and Low and Oscillating Shear Stress , 1985, Arteriosclerosis.

[4]  P. Laura,et al.  Analysis of pulsatile blood flow: a carotid siphon model. , 1987, Journal of biomedical engineering.

[5]  P. Hoskins.  Quantitative techniques in arterial Doppler ultrasound. , 1990, Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics.

[6]  K. Perktold,et al.  Numerical 3D-stimulation of pulsatile wall shear stress in an arterial T-bifurcation model. , 1990, Journal of biomedical engineering.

[7]  M. Hennerici,et al.  Variability of flow patterns in the normal carotid bifurcation. , 1990, Atherosclerosis.

[8]  X. Y. Xu,et al.  A Review of the Numerical Analysis of Blood Flow in Arterial Bifurcations , 1990, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[9]  Michael M. Resch,et al.  Pulsatile non-Newtonian flow characteristics in a three-dimensional human carotid bifurcation model. , 1991, Journal of biomechanical engineering.

[10]  R. Nerem,et al.  A numerical calculation of flow in a curved tube model of the left main coronary artery. , 1991, Journal of biomechanics.

[11]  R. Herfkens,et al.  Phase contrast cine magnetic resonance imaging. , 1991, Magnetic resonance quarterly.

[12]  Michael M. Resch,et al.  Pulsatile non-Newtonian blood flow in three-dimensional carotid bifurcation models: a numerical study of flow phenomena under different bifurcation angles. , 1991, Journal of biomedical engineering.

[13]  Michael M. Resch,et al.  Three-dimensional numerical analysis of pulsatile flow and wall shear stress in the carotid artery bifurcation. , 1991, Journal of biomechanics.

[14]  Morton H. Friedman,et al.  Hemodynamics and the Arterial Wall , 1992 .

[15]  O. Smedby.  Angiographic methods for the study of fluid mechanical factors in atherogenesis. , 1992, Acta radiologica. Supplementum.

[16]  D D Duncan,et al.  Effects of arterial compliance and non-Newtonian rheology on correlations between intimal thickness and wall shear. , 1992, Journal of biomechanical engineering.

[17]  O Smedby,et al.  Flow disturbances in early femoral atherosclerosis--an in vivo study with digitized cineangiography. , 1993, Journal of biomechanics.

[18]  Z Lou,et al.  A computer simulation of the blood flow at the aortic bifurcation with flexible walls. , 1993, Journal of biomechanical engineering.

[19]  Z Lou,et al.  A computer simulation of the non-Newtonian blood flow at the aortic bifurcation. , 1993, Journal of biomechanics.

[20]  D. Ku,et al.  Pulsatile velocity measurements in a model of the human abdominal aorta under simulated exercise and postprandial conditions. , 1994, Journal of biomechanical engineering.

[21]  D. Ku,et al.  Pulsatile velocity measurements in a model of the human abdominal aorta under resting conditions. , 1994, Journal of biomechanical engineering.

[22]  D. Steinman,et al.  Simulation of non-Newtonian blood flow in an end-to-side anastomosis. , 1994, Biorheology.

[23]  D. Steinman,et al.  The effect of wall distensibility on flow in a two-dimensional end-to-side anastomosis. , 1994, Journal of biomechanical engineering.

[24]  K. Perktold,et al.  Computer simulation of local blood flow and vessel mechanics in a compliant carotid artery bifurcation model. , 1995, Journal of biomechanics.

[25]  C Kleinstreuer,et al.  A focal stress gradient-dependent mass transfer mechanism for atherogenesis in branching arteries. , 1996, Medical engineering & physics.

[26]  C Kleinstreuer,et al.  Effect of carotid artery geometry on the magnitude and distribution of wall shear stress gradients. , 1996, Journal of vascular surgery.

[27]  S. Nilsson,et al.  Development of femoral atherosclerosis in relation to flow disturbances. , 1996, Journal of biomechanics.

[28]  Thomas J. R. Hughes,et al.  Computational investigations in vascular disease , 1996 .

[29]  R. Sayers,et al.  Elastase-induced matrix degradation in arterial organ cultures: an in vitro model of aneurysmal disease. , 1996, Journal of vascular surgery.

[30]  F. Migliavacca,et al.  A computational pulsatile model of the bidirectional cavopulmonary anastomosis: the influence of pulmonary forward flow. , 1996, Journal of biomechanical engineering.

[31]  K Perktold,et al.  Pulsatile albumin transport in large arteries: a numerical simulation study. , 1996, Journal of biomechanical engineering.

[32]  X. Li,et al.  Convective mass transfer at the carotid bifurcation. , 1997, Journal of biomechanics.

[33]  A. Gnasso,et al.  In vivo association between low wall shear stress and plaque in subjects with asymmetrical carotid atherosclerosis. , 1997, Stroke.

[34]  C. R. Ethier,et al.  Oxygen mass transfer calculations in large arteries. , 1997, Journal of biomechanical engineering.

[35]  D N Firmin,et al.  Blood flow patterns in the thoracic aorta studied with three‐directional MR velocity mapping: The effects of age and coronary artery disease , 1997, Journal of magnetic resonance imaging : JMRI.

[36]  P. Serruys,et al.  Evaluation of endothelial shear stress and 3D geometry as factors determining the development of atherosclerosis and remodeling in human coronary arteries in vivo. Combining 3D reconstruction from angiography and IVUS (ANGUS) with computational fluid dynamics. , 1997, Arteriosclerosis, thrombosis, and vascular biology.

[37]  C. Kleinstreuer,et al.  Computational design of a bypass graft that minimizes wall shear stress gradients in the region of the distal anastomosis. , 1997, Journal of vascular surgery.

[38]  R S Reneman,et al.  Differences in near-wall shear rate in the carotid artery within subjects are associated with different intima-media thicknesses. , 1998, Arteriosclerosis, thrombosis, and vascular biology.

[39]  B. Rutt,et al.  Hemodynamics of human carotid artery bifurcations: computational studies with models reconstructed from magnetic resonance imaging of normal subjects. , 1998, Journal of vascular surgery.

[40]  M H Buonocore,et al.  Visualizing blood flow patterns using streamlines, arrows, and particle paths , 1998, Magnetic resonance in medicine.

[41]  P Boesiger,et al.  Automatic accurate non-invasive quantitation of blood flow, cross-sectional vessel area, and wall shear stress by modelling of magnetic resonance velocity data. , 1998, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[42]  B. Kuban,et al.  Validated computation of physiologic flow in a realistic coronary artery branch. , 1997, Journal of biomechanics.

[43]  C. Taylor,et al.  Predictive medicine: computational techniques in therapeutic decision-making. , 1999, Computer aided surgery : official journal of the International Society for Computer Aided Surgery.

[44]  F. N. van de Vosse,et al.  The influence of the non-Newtonian properties of blood on the flow in large arteries: steady flow in a carotid bifurcation model. , 1999, Journal of biomechanics.

[45]  T. Hughes,et al.  Effect of exercise on hemodynamic conditions in the abdominal aorta. , 1999, Journal of vascular surgery.

[46]  Q. Long,et al.  Reconstruction of blood flow patterns in human arteries , 1999, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[47]  C Kleinstreuer,et al.  Computer simulation and geometric design of endarterectomized carotid artery bifurcations. , 2000, Critical reviews in biomedical engineering.

[48]  M. Yacoub,et al.  Asymmetric redirection of flow through the heart , 2000, Nature.

[49]  D A Steinman,et al.  Simulated pathline visualization of computed periodic blood flow patterns. , 2000, Journal of biomechanics.

[50]  René M. Botnar,et al.  Hemodynamics in the carotid artery bifurcation: a comparison between numerical simulations and in vitro MRI measurements. , 2000, Journal of biomechanics.

[51]  J J Wentzel,et al.  Relationship Between Neointimal Thickness and Shear Stress After Wallstent Implantation in Human Coronary Arteries , 2001, Circulation.

[52]  C. R. Ethier,et al.  Requirements for mesh resolution in 3D computational hemodynamics. , 2001, Journal of biomechanical engineering.

[53]  J J Wentzel,et al.  Shear-Stress and Wall-Stress Regulation of Vascular Remodeling After Balloon Angioplasty: Effect of Matrix Metalloproteinase Inhibition , 2001, Circulation.

[54]  S. Deutsch,et al.  Integrating particle image velocimetry and laser Doppler velocimetry measurements of the regurgitant flow field past mechanical heart valves. , 2001, Artificial organs.

[55]  G. Truskey,et al.  Hemodynamic parameters and early intimal thickening in branching blood vessels. , 2001, Critical reviews in biomedical engineering.

[56]  D. Saloner,et al.  Numerical analysis of flow through a severely stenotic carotid artery bifurcation. , 2002, Journal of biomechanical engineering.

[57]  Chander Sadasivan,et al.  Angiographic quantification of contrast medium washout from cerebral aneurysms after stent placement. , 2002, AJNR. American journal of neuroradiology.

[58]  Attila Thury,et al.  High shear stress after successful balloon angioplasty is associated with restenosis and target lesion revascularization. , 2002, American heart journal.

[59]  R Pietrabissa,et al.  Multiscale modelling as a tool to prescribe realistic boundary conditions for the study of surgical procedures. , 2002, Biorheology.

[60]  M. Gounis,et al.  The physics of endoluminal stenting in the treatment of cerebrovascular aneurysms , 2002, Neurological research.

[61]  B. Rutt,et al.  Reconstruction of carotid bifurcation hemodynamics and wall thickness using computational fluid dynamics and MRI , 2002, Magnetic resonance in medicine.

[62]  A D Hughes,et al.  Inter-individual variations in wall shear stress and mechanical stress distributions at the carotid artery bifurcation of healthy humans. , 2002, Journal of biomechanics.

[63]  Ajit P Yoganathan,et al.  An analysis of turbulent shear stresses in leakage flow through a bileaflet mechanical prostheses. , 2002, Journal of biomechanical engineering.

[64]  Rainald Löhner,et al.  Blood flow modeling in carotid arteries with computational fluid dynamics and MR imaging. , 2002, Academic radiology.

[65]  D Liepsch,et al.  The discrimination of stenosed carotid bifurcation models with smooth and irregular plaque surface. Part I. Laser and ultrasonic Doppler flow studies. , 2002, Medical engineering & physics.

[66]  I. Marshall,et al.  Quantitative comparison of CFD predicted and MRI measured velocity fields in a carotid bifurcation phantom. , 2002, Biorheology.

[67]  Kyehan Rhee,et al.  Intraaneurysmal flow changes affected by clip location and occlusion magnitude in a lateral aneurysm model. , 2003, Medical engineering & physics.

[68]  Ian Marshall,et al.  MRI measurement of time‐resolved wall shear stress vectors in a carotid bifurcation model, and comparison with CFD predictions , 2003, Journal of magnetic resonance imaging : JMRI.

[69]  T. Yoshimoto,et al.  Hemodynamic analysis of an adult vein of Galen aneurysm malformation by use of 3D image-based computational fluid dynamics. , 2003, AJNR. American journal of neuroradiology.

[70]  D. Holdsworth,et al.  Image-based computational simulation of flow dynamics in a giant intracranial aneurysm. , 2003, AJNR. American journal of neuroradiology.

[71]  A D Augst,et al.  Accuracy and reproducibility of CFD predicted wall shear stress using 3D ultrasound images. , 2003, Journal of biomechanical engineering.

[72]  F. Migliavacca,et al.  Computational fluid dynamics simulations in realistic 3-D geometries of the total cavopulmonary anastomosis: the influence of the inferior caval anastomosis. , 2003, Journal of biomechanical engineering.

[73]  Christopher P. Cheng,et al.  Comparison of abdominal aortic hemodynamics between men and women at rest and during lower limb exercise. , 2003, Journal of vascular surgery.

[74]  Steven H Frankel,et al.  Numerical modeling of pulsatile turbulent flow in stenotic vessels. , 2003, Journal of biomechanical engineering.

[75]  David Saloner,et al.  Physiological Flow Studies in Exact-Replica Atherosclerotic Carotid Bifurcations , 2003 .

[76]  A. Wahle,et al.  Effect of Endothelial Shear Stress on the Progression of Coronary Artery Disease, Vascular Remodeling, and In-Stent Restenosis in Humans: In Vivo 6-Month Follow-Up Study , 2003, Circulation.

[77]  Fumio Asakura,et al.  Evaluation of intra-aneurysmal blood flow by digital subtraction angiography: blood flow change after coil embolization. , 2003, Surgical neurology.

[78]  Alastair J. Martin,et al.  Computational approach to quantifying hemodynamic forces in giant cerebral aneurysms. , 2003, AJNR. American journal of neuroradiology.

[79]  A. Hughes,et al.  Reproducibility Study of Magnetic Resonance Image-Based Computational Fluid Dynamics Prediction of Carotid Bifurcation Flow , 2003, Annals of Biomedical Engineering.

[80]  Christopher P. Cheng,et al.  Quantification of Wall Shear Stress in Large Blood Vessels Using Lagrangian Interpolation Functions with Cine Phase-Contrast Magnetic Resonance Imaging , 2002, Annals of Biomedical Engineering.

[81]  M. R. Kaazempur-Mofrad,et al.  Computational Analysis of the Effects of Exercise on Hemodynamics in the Carotid Bifurcation , 2003, Annals of Biomedical Engineering.

[82]  David A. Steinman,et al.  Robust and objective decomposition and mapping of bifurcating vessels , 2004, IEEE Transactions on Medical Imaging.

[83]  B. Rutt,et al.  Computational Blood Flow Modeling Based on In Vivo Measurements , 1999, Annals of Biomedical Engineering.

[84]  David A. Steinman,et al.  Image-Based Computational Fluid Dynamics Modeling in Realistic Arterial Geometries , 2002, Annals of Biomedical Engineering.

[85]  D. Saloner,et al.  Transport of contrast agents in contrast-enhanced magnetic resonance angiography. , 2004, Magnetic resonance imaging.

[86]  C. R. Ethier,et al.  Accuracy of Computational Hemodynamics in Complex Arterial Geometries Reconstructed from Magnetic Resonance Imaging , 2004, Annals of Biomedical Engineering.

[87]  T. Yoshimoto,et al.  Computational simulation of therapeutic parent artery occlusion to treat giant vertebrobasilar aneurysm. , 2004, AJNR. American journal of neuroradiology.

[88]  H. Dwyer,et al.  A simulated dye method for flow visualization with a computational model for blood flow. , 2004, Journal of biomechanics.

[89]  B. Rutt,et al.  Reproducibility of Image-Based Computational Fluid Dynamics Models of the Human Carotid Bifurcation , 2003, Annals of Biomedical Engineering.

[90]  D. Steinman,et al.  Two-equation turbulence modeling of pulsatile flow in a stenosed tube. , 2004, Journal of biomechanical engineering.

[91]  M. Buonocore,et al.  Four‐dimensional magnetic resonance velocity mapping of blood flow patterns in the aorta in patients with atherosclerotic coronary artery disease compared to age‐matched normal subjects , 2004, Journal of magnetic resonance imaging : JMRI.

[92]  A. Gnasso,et al.  Wall Shear Stress Is Associated With Intima-Media Thickness and Carotid Atherosclerosis in Subjects at Low Coronary Heart Disease Risk , 2004, Stroke.

[93]  David A Steinman,et al.  Real-time numerical simulation of Doppler ultrasound in the presence of nonaxial flow. , 2005, Ultrasound in medicine & biology.