Nip it in the bud: potentialfor the early treatment of osteoarthritis.

[1]  A. Haudenschild,et al.  Bromodomain-containing-protein-4 and cyclin-dependent-kinase-9 inhibitors interact synergistically in vitro and combined treatment reduces post-traumatic osteoarthritis severity in mice. , 2020, Osteoarthritis and cartilage.

[2]  R. O’Keefe,et al.  LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis , 2020, Nature Communications.

[3]  Xiaolei Zhang,et al.  BRD4 inhibition attenuates inflammatory response in microglia and facilitates recovery after spinal cord injury in rats , 2019, Journal of cellular and molecular medicine.

[4]  R. Brophy,et al.  Osteoarthritis following meniscus and ligament injury: insights from translational studies and animal models , 2018, Current opinion in rheumatology.

[5]  S. Günther,et al.  Bromodomain Drug Discovery - the Past, the Present, and the Future. , 2018, Chemical record.

[6]  Matthew J. Silva,et al.  Post-Traumatic Osteoarthritis in Mice Following Mechanical Injury to the Synovial Joint , 2017, Scientific Reports.

[7]  R. O’Keefe,et al.  Inflammation and epigenetic regulation in osteoarthritis , 2017, Connective tissue research.

[8]  P. Wiernik.  Alvocidib (flavopiridol) for the treatment of chronic lymphocytic leukemia , 2016, Expert opinion on investigational drugs.

[9]  Steven R Goldring,et al.  Early knee osteoarthritis , 2015, RMD Open.

[10]  B. Christiansen,et al.  Cyclin‐Dependent Kinase 9 Inhibition Protects Cartilage From the Catabolic Effects of Proinflammatory Cytokines , 2014, Arthritis & rheumatology.

[11]  A. Belkina,et al.  BET Protein Function Is Required for Inflammation: Brd2 Genetic Disruption and BET Inhibitor JQ1 Impair Mouse Macrophage Inflammatory Responses , 2013, The Journal of Immunology.

[12]  B. Christiansen,et al.  Musculoskeletal changes following non-invasive knee injury using a novel mouse model of post-traumatic osteoarthritis. , 2012, Osteoarthritis and cartilage.

[13]  Martin Englund,et al.  Prevalence of Tibiofemoral Osteoarthritis 15 Years after Nonoperative Treatment of Anterior Cruciate Ligament Injury , 2008, The American journal of sports medicine.

[14]  E. Roos,et al.  Impact of type of meniscal tear on radiographic and symptomatic knee osteoarthritis: a sixteen-year followup of meniscectomy with matched controls. , 2003, Arthritis and rheumatism.

[15]  H. Roos,et al.  Osteoarthritis of the knee after injury to the anterior cruciate ligament or meniscus: the influence of time and age. , 1995, Osteoarthritis and cartilage.

[16]  K. Athanasiou,et al.  Inhibition of CDK9 prevents mechanical injury-induced inflammation, apoptosis and matrix degradation in cartilage explants. , 2016, European cells & materials.