Exercising calf muscle changes correlate with pH, PCr recovery and maximum oxidative phosphorylation

Skeletal muscle metabolism is impaired in disorders like diabetes mellitus or peripheral vascular disease. The skeletal muscle echo planar imaging (EPI) signal (SEPI) and its relation to energy metabolism are still debated.

[1]  L. Ploutz-Snyder,et al.  Relationship between muscle T2* relaxation properties and metabolic state: a combined localized 31P-spectroscopy and 1H-imaging study , 2000, European Journal of Applied Physiology.

[2]  P. Carlier,et al.  Muscle blood flow and oxygenation measured by NMR imaging and spectroscopy , 2006, NMR in biomedicine.

[3]  Sasan Partovi,et al.  Skeletal muscle BOLD MRI: From underlying physiological concepts to its usefulness in clinical conditions , 2012, Journal of magnetic resonance imaging : JMRI.

[4]  Ewald Moser,et al.  Semi-LASER localized dynamic 31P magnetic resonance spectroscopy in exercising muscle at ultra-high magnetic field , 2011, Magnetic resonance in medicine.

[5]  Arend Heerschap,et al.  Towards 1H-MRSI of the human brain at 7T with slice-selective adiabatic refocusing pulses , 2008, Magnetic Resonance Materials in Physics, Biology and Medicine.

[6]  Ewald Moser,et al.  Comparing localized and nonlocalized dynamic 31P magnetic resonance spectroscopy in exercising muscle at 7T , 2012, Magnetic resonance in medicine.

[7]  Ewald Moser,et al.  Ultra-high-field magnetic resonance: Why and when? , 2010, World journal of radiology.

[8]  P. Matthews,et al.  Energetics of human muscle: Exercise‐induced ATP depletion , 1986, Magnetic resonance in medicine.

[9]  P. Carlier,et al.  Multiparametric NMR-based assessment of skeletal muscle perfusion and metabolism during exercise in elderly persons: preliminary findings. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[10]  E. Moser,et al.  Effect of ischemic preconditioning in skeletal muscle measured by functional magnetic resonance imaging and spectroscopy: a randomized crossover trial , 2011, Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance.

[11]  G. Radda.  Control of Energy Metabolism During Muscle Contraction , 1996, Diabetes.

[12]  P. Carlier,et al.  Splitting of Pi and other 31P NMR anomalies of skeletal muscle metabolites in canine muscular dystrophy , 2012, NMR in biomedicine.

[13]  B. Prior,et al.  Functional Magnetic Resonance Imaging of Muscle , 2000, Exercise and sport sciences reviews.

[14]  A. Caprihan,et al.  Changes in muscle proton transverse relaxation times and acidosis during exercise and recovery. , 1995, Journal of applied physiology.

[15]  Theodore F. Towse,et al.  BOLD MRI mapping of transient hyperemia in skeletal muscle after single contractions , 2004, NMR in biomedicine.

[16]  E. Moser,et al.  Automatic model‐based analysis of skeletal muscle BOLD‐MRI in reactive hyperemia , 2013, Journal of Magnetic Resonance Imaging.

[17]  V. Gulani,et al.  Intracellular acidification and volume increases explain R2 decreases in exercising muscle , 2002, Magnetic resonance in medicine.

[18]  J. Kent‐Braun,et al.  Dual gradient‐echo MRI of post‐contraction changes in skeletal muscle blood volume and oxygenation , 2007, Magnetic resonance in medicine.

[19]  G. Heinze,et al.  Heme arginate improves reperfusion patterns after ischemia: a randomized, placebo-controlled trial in healthy male subjects , 2012, Journal of Cardiovascular Magnetic Resonance.

[20]  D. Manners,et al.  Reduced oxidative phosphorylation and proton efflux suggest reduced capillary blood supply in skeletal muscle of patients with dermatomyositis and polymyositis: a quantitative 31P-magnetic resonance spectroscopy and MRI study. , 2002, Brain : a journal of neurology.

[21]  D. Graveron-Demilly,et al.  Java-based graphical user interface for the MRUI quantitation package , 2001, Magnetic Resonance Materials in Physics, Biology and Medicine.

[22]  G. Kemp,et al.  Interrelations of ATP synthesis and proton handling in ischaemically exercising human forearm muscle studied by 31P magnetic resonance spectroscopy , 2001, The Journal of physiology.

[23]  E. Moser,et al.  Comparison of measuring energy metabolism by different 31P‐magnetic resonance spectroscopy techniques in resting, ischemic, and exercising muscle , 2012, Magnetic resonance in medicine.

[24]  Shoko Nioka,et al.  Skeletal muscle energetics with PNMR: personal views and historic perspectives , 2006, NMR in biomedicine.

[25]  M. Noseworthy,et al.  BOLD Magnetic Resonance Imaging of Skeletal Muscle , 2003, Seminars in musculoskeletal radiology.

[26]  Ewald Moser,et al.  Absolute quantification of phosphorus metabolite concentrations in human muscle in vivo by 31P MRS: a quantitative review , 2007, NMR in biomedicine.

[27]  A G Webb,et al.  In vivo 31P MRS detection of an alkaline inorganic phosphate pool with short T1 in human resting skeletal muscle , 2010, NMR in biomedicine.

[28]  S. Ward,et al.  Muscle metabolism and activation heterogeneity by combined 31P chemical shift and T2 imaging, and pulmonary O2 uptake during incremental knee-extensor exercise , 2013, Journal of applied physiology.

[29]  Y. le Fur,et al.  Mitochondrial function and increased convective O2 transport: implications for the assessment of mitochondrial respiration in vivo. , 2013, Journal of applied physiology.

[30]  Ewald Moser,et al.  7‐T MR—from research to clinical applications? , 2012, NMR in biomedicine.

[31]  Ian R. Lanza,et al.  Methods for Assessing Mitochondrial Function in Diabetes , 2013, Diabetes.

[32]  G K Radda,et al.  Quantitative interpretation of bioenergetic data from 31P and 1H magnetic resonance spectroscopic studies of skeletal muscle: an analytical review. , 1994, Magnetic resonance quarterly.

[33]  Ewald Moser,et al.  A form‐fitted three channel 31P, two channel 1H transceiver coil array for calf muscle studies at 7 T , 2015, Magnetic resonance in medicine.

[34]  K. Claeys,et al.  Investigating glycogenosis type III patients with multi-parametric functional NMR imaging and spectroscopy , 2010, Neuromuscular Disorders.

[35]  J. Mallow,et al.  A form-fitted 3 channel 31P, two channel 1H transceive coil for calf muscle studies at 7 T , 2013 .

[36]  Vanhamme,et al.  Improved method for accurate and efficient quantification of MRS data with use of prior knowledge , 1997, Journal of magnetic resonance.

[37]  E. Moser,et al.  Signal-to-Noise Ratio Analysis of 31 P MRS in Skeletal Muscle : Influence of Localization Schemes , RF Coils and Field Strength , 2012 .

[38]  Klaas Nicolay,et al.  Dynamic MRS and MRI of skeletal muscle function and biomechanics , 2006, NMR in Biomedicine.

[39]  P. Zaniol,et al.  in vivo assessment of mitochondrial functionality in human gastrocnemius muscle by 31P MRS. The role of pH in the evaluation of phosphocreatine and inorganic phosphate recoveries from exercise , 1993, NMR in biomedicine.

[40]  R. Canby,et al.  Acute effects of exercise on MR imaging of skeletal muscle in normal volunteers. , 1988, AJR. American journal of roentgenology.

[41]  B. Damon,et al.  Absolute and relative contributions of BOLD effects to the muscle functional MRI signal intensity time course: Effect of exercise intensity , 2007, Magnetic resonance in medicine.