Decellularized heart extracellular matrix alleviates activation of hiPSC-derived cardiac fibroblasts

[1]  Su Kyeom Kim,et al.  Three-dimensional heart extracellular matrix enhances chemically induced direct cardiac reprogramming , 2022, Science advances.

[2]  G. Mensah,et al.  The Global Burden of Cardiovascular Diseases and Risk: A Compass for Future Health. , 2022, Journal of the American College of Cardiology.

[3]  P. Ellinor,et al.  Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy , 2022, Nature.

[4]  D. Westermann,et al.  Human cardiac organoids to model COVID‐19 cytokine storm induced cardiac injuries , 2022, bioRxiv.

[5]  B. Ren,et al.  Improved epicardial cardiac fibroblast generation from iPSCs. , 2021, Journal of molecular and cellular cardiology.

[6]  Sean P. Palecek,et al.  Developmental lineage of human pluripotent stem cell‐derived cardiac fibroblasts affects their functional phenotype , 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[7]  D. Menick,et al.  Multicellular Human Cardiac Organoids Transcriptomically Model Distinct Tissue-Level Features of Adult Myocardium , 2021, International journal of molecular sciences.

[8]  C. Denning,et al.  Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease , 2021, Journal of the American Heart Association.

[9]  H. Yagi,et al.  Fibronectin mediates activation of stromal fibroblasts by SPARC in endometrial cancer cells , 2021, BMC cancer.

[10]  P. Doevendans,et al.  Massive expansion and cryopreservation of functional human induced pluripotent stem cell-derived cardiomyocytes , 2021, STAR protocols.

[11]  R. Steeds,et al.  Myocardial Fibrosis as a Predictor of Sudden Death in Patients With Coronary Artery Disease. , 2021, Journal of the American College of Cardiology.

[12]  Ying Mei,et al.  Targeting HIF‐α for robust prevascularization of human cardiac organoids , 2020, Journal of tissue engineering and regenerative medicine.

[13]  C. Mummery,et al.  Isogenic Sets of hiPSC-CMs Harboring Distinct KCNH2 Mutations Differ Functionally and in Susceptibility to Drug-Induced Arrhythmias , 2020, Stem cell reports.

[14]  Jorge Oliver-De La Cruz,et al.  Multiscale Analysis of Extracellular Matrix Remodeling in the Failing Heart. , 2020, Circulation research.

[15]  A. McCulloch,et al.  Maintaining resting cardiac fibroblasts in vitro by disrupting mechanotransduction , 2020, PloS one.

[16]  James B. Hu,et al.  Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes. , 2020, Cell stem cell.

[17]  C. Mummery,et al.  Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease , 2020, Cell stem cell.

[18]  G. Hardiman,et al.  Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity , 2020, Nature Biomedical Engineering.

[19]  S. Gerecht,et al.  iPSC-derived endothelial cell response to hypoxia via SDF1a/CXCR4 axis facilitates incorporation to revascularize ischemic retina. , 2020, JCI insight.

[20]  Giovanni Parmigiani,et al.  ComBat-seq: batch effect adjustment for RNA-seq count data , 2020, bioRxiv.

[21]  I. Dixon,et al.  An Improved Method of Maintaining Primary Murine Cardiac Fibroblasts in Two-Dimensional Cell Culture , 2019, Scientific Reports.

[22]  D. Strauss,et al.  Clinical Trial in a Dish: Personalized Stem Cell–Derived Cardiomyocyte Assay Compared With Clinical Trial Results for Two QT‐Prolonging Drugs , 2019, Clinical and translational science.

[23]  Joseph C. Wu,et al.  Generation of Quiescent Cardiac Fibroblasts from Human Induced Pluripotent Stem Cells for In Vitro Modeling of Cardiac Fibrosis. , 2019, Circulation research.

[24]  O. Centurión,et al.  Myocardial Fibrosis as a Pathway of Prediction of Ventricular Arrhythmias and Sudden Cardiac Death in Patients With Nonischemic Dilated Cardiomyopathy , 2019, Critical pathways in cardiology.

[25]  S. Harding,et al.  Multi-cellularity in cardiac tissue engineering, how close are we to native heart tissue? , 2019, Journal of Muscle Research and Cell Motility.

[26]  J. Thomson,et al.  Functional cardiac fibroblasts derived from human pluripotent stem cells via second heart field progenitors , 2019, Nature Communications.

[27]  Olga Tanaseichuk,et al.  Metascape provides a biologist-oriented resource for the analysis of systems-level datasets , 2019, Nature Communications.

[28]  Michael E. Davis,et al.  Decellularized Extracellular Matrix Materials for Cardiac Repair and Regeneration , 2019, Advanced healthcare materials.

[29]  Mohammad Hossein Khosravi,et al.  Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017 , 2018, Lancet.

[30]  K. Christman,et al.  A Bioprinted Cardiac Patch Composed of Cardiac‐Specific Extracellular Matrix and Progenitor Cells for Heart Repair , 2018, Advanced healthcare materials.

[31]  N. Vaziri,et al.  New insights into TGF-β/Smad signaling in tissue fibrosis. , 2018, Chemico-biological interactions.

[32]  Xin Yi Chan,et al.  Differential HDAC6 Activity Modulates Ciliogenesis and Subsequent Mechanosensing of Endothelial Cells Derived from Pluripotent Stem Cells. , 2018, Cell reports.

[33]  A. Pointon,et al.  Characterization and Validation of a Human 3D Cardiac Microtissue for the Assessment of Changes in Cardiac Pathology , 2018, Scientific Reports.

[34]  M. Tallquist.  Cardiac fibroblasts: from origin to injury. , 2018, Current opinion in physiology.

[35]  J. Molkentin,et al.  Fibroblast-specific TGF-β-Smad2/3 signaling underlies cardiac fibrosis. , 2017, The Journal of clinical investigation.

[36]  Ying Mei,et al.  Inspiration from heart development: Biomimetic development of functional human cardiac organoids. , 2017, Biomaterials.

[37]  Sean P. Palecek,et al.  Directed differentiation and long-term maintenance of epicardial cells derived from human pluripotent stem cells under fully defined conditions , 2017, Nature Protocols.

[38]  G. Figtree,et al.  Cardiac spheroids as promising in vitro models to study the human heart microenvironment , 2017, Scientific Reports.

[39]  A. McCulloch,et al.  Mechanical regulation of cardiac fibroblast profibrotic phenotypes , 2017, Molecular biology of the cell.

[40]  Tong Liu,et al.  Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure , 2017, Front. Physiol..

[41]  Ying Mei,et al.  Cell number per spheroid and electrical conductivity of nanowires influence the function of silicon nanowired human cardiac spheroids. , 2017, Acta biomaterialia.

[42]  Sean P. Palecek,et al.  Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions , 2016, Nature Biomedical Engineering.

[43]  K. Christman,et al.  Controlling stem cell behavior with decellularized extracellular matrix scaffolds. , 2016, Current opinion in solid state & materials science.

[44]  Bozhi Tian,et al.  Nanowires and Electrical Stimulation Synergistically Improve Functions of hiPSC Cardiac Spheroids. , 2016, Nano letters.

[45]  Virpi Talman,et al.  Cardiac fibrosis in myocardial infarction—from repair and remodeling to regeneration , 2016, Cell and Tissue Research.

[46]  F. Recchia,et al.  Follistatin‐like 1 promotes cardiac fibroblast activation and protects the heart from rupture , 2016, EMBO molecular medicine.

[47]  Russ B Altman,et al.  Human induced pluripotent stem cell–derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity , 2016, Nature Medicine.

[48]  K. Yutzey,et al.  Cardiac Fibrosis: The Fibroblast Awakens. , 2016, Circulation research.

[49]  S. Badylak,et al.  Methods of tissue decellularization used for preparation of biologic scaffolds and in vivo relevance. , 2015, Methods.

[50]  T. Borg,et al.  Silicon nanowire-induced maturation of cardiomyocytes derived from human induced pluripotent stem cells. , 2015, Nano letters.

[51]  Raphael Gottardo,et al.  Orchestrating high-throughput genomic analysis with Bioconductor , 2015, Nature Methods.

[52]  S. Agarwal.  Integrins and cadherins as therapeutic targets in fibrosis , 2014, Front. Pharmacol..

[53]  M. Sheetz,et al.  Heart extracellular matrix supports cardiomyocyte differentiation of mouse embryonic stem cells. , 2013, Journal of bioscience and bioengineering.

[54]  M. Suematsu,et al.  Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes. , 2013, Cell stem cell.

[55]  Sean P. Palecek,et al.  Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions , 2012, Nature Protocols.

[56]  A. Bradshaw,et al.  The Function of SPARC as a Mediator of Fibrosis , 2012, The open rheumatology journal.

[57]  Euan A. Ashley,et al.  Patient-Specific Induced Pluripotent Stem Cells as a Model for Familial Dilated Cardiomyopathy , 2012, Science Translational Medicine.

[58]  V. Moulin,et al.  Angiogenic properties of myofibroblasts isolated from normal human skin wounds , 2012, Angiogenesis.

[59]  J. Pepper,et al.  Midwall fibrosis is an independent predictor of mortality in patients with aortic stenosis. , 2011, Journal of the American College of Cardiology.

[60]  Marie M. Lockhart,et al.  Extracellular matrix and heart development. , 2011, Birth defects research. Part A, Clinical and molecular teratology.

[61]  H. Duffy,et al.  Fibroblasts and Myofibroblasts: What Are We Talking About? , 2011, Journal of cardiovascular pharmacology.

[62]  R. Kalluri,et al.  Origins of cardiac fibroblasts. , 2010, Circulation research.

[63]  E. Kardami,et al.  Cardiac fibroblast to myofibroblast differentiation in vivo and in vitro: Expression of focal adhesion components in neonatal and adult rat ventricular myofibroblasts , 2010, Developmental dynamics : an official publication of the American Association of Anatomists.

[64]  L. Valdes‐Cruz,et al.  Preliminary Experience With Cardiac Reconstruction Using Decellularized Porcine Extracellular Matrix Scaffold: Human Applications in Congenital Heart Disease , 2010, World journal for pediatric & congenital heart surgery.

[65]  N. Frangogiannis,et al.  The role of TGF-β Signaling in Myocardial Infarction and Cardiac Remodeling , 2007 .

[66]  J. Mesirov,et al.  From the Cover: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005 .

[67]  H. Kleinman,et al.  Matrigel: basement membrane matrix with biological activity. , 2005, Seminars in cancer biology.

[68]  Jean YH Yang,et al.  Bioconductor: open software development for computational biology and bioinformatics , 2004, Genome Biology.

[69]  M. Daly,et al.  PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes , 2003, Nature Genetics.

[70]  C. Streuli,et al.  Control of Integrin Expression by Extracellular Matrix (*) , 1995, The Journal of Biological Chemistry.

[71]  R. Markwald,et al.  Extracellular matrix from embryonic myocardium elicits an early morphogenetic event in cardiac endothelial differentiation. , 1987, Developmental biology.

[72]  Gwpo Workplan.  Global , 2021, Encyclopedia of the UN Sustainable Development Goals.

[73]  Sean P. Palecek,et al.  Directed Endothelial Progenitor Differentiation from Human Pluripotent Stem Cells Via Wnt Activation Under Defined Conditions. , 2016, Methods in molecular biology.

[74]  Cedric E. Ginestet.  ggplot2: Elegant Graphics for Data Analysis , 2011 .

[75]  D. Milewicz,et al.  Small interfering RNA inhibition of SPARC attenuates the profibrotic effect of transforming growth factor β1 in cultured normal human fibroblasts , 2005 .

[76]  R. Dickson,et al.  Regulation of the expression of c-Myc by beta1 integrins in epithelial cells. , 2001, Oncogene.