OBSERVATIONS ON THE RELATION OF THE VIRUS CAUS- ING RABBIT PAPILLOMAS TO THE CANCERS DERIVING THEREFROM I. THE INFLUENCE OF TIIE HOST SP~.CZES AND OF TIIE PATHOGENIC ACTIVITY AND CONCENTRATION OF THE VIRUS

The carcinomas deriving from the papillomas induced with a virus in domestic rabbits (1) have this virus as their primary cause. The present paper is concerned with the carcinogenic effect of various strains of the virus,--meaning thereby the infective materials procured from the "spontaneous" papillomas of different cottontail rabbits,--and with the influence of the concentration of the inoculum, and the method whereby it is introduced. In corollary certain unusual tumors will be described which have followed upon the papillomatosis engendered by the virus in a cottontail rabbit.