Photodynamic therapy and its applications in gynaecology

Photodynamic therapy (PDT) is a medical treatment by which a combination of visible light and a sensitising drug causes the destruction of selected cells. A drug without dark toxicity is introduced into the body and accumulates preferentially in rapidly dividing cells. When the drug reaches an optimal concentration in diseased versus healthy tissue a measured light dose of appropriate wavelength is shone onto the diseased tissue. Light activates the drug and elicits the toxic reaction in the presence of oxygen.

[1]  M W Berns,et al.  Laser photoradiation therapy of cancer. , 1986, Cancer research.

[2]  E J BALDES,et al.  The photodynamic properties of a particular hematoporphyrin derivative. , 1960, Archives of dermatology.

[3]  H. Kato,et al.  Treatment of vaginal carcinoma with laser photoirradiation following administration of haematoporphyrin derivative. Report of a case. , 1982, Annales chirurgiae et gynaecologiae.

[4]  J. Fuchs,et al.  The role of oxygen in cutaneous photodynamic therapy. , 1998, Free radical biology & medicine.

[5]  R. Jindra,et al.  5-aminolevulinic acid-mediated photodynamic therapy of intraepithelial neoplasia and human papillomavirus of the uterine cervix--a new experimental approach. , 1999, Cancer detection and prevention.

[6]  M W Berns,et al.  Photodynamic destruction of endometrial tissue with topical 5-aminolevulinic acid in rats and rabbits. , 1994, American journal of obstetrics and gynecology.

[7]  B. Monk,et al.  Photodynamic therapy using topically applied dihematoporphyrin ether in the treatment of cervical intraepithelial neoplasia. , 1997, Gynecologic oncology.

[8]  M. Berns,et al.  Photoradiation therapy of gynecologic malignancies. , 1984, Gynecologic oncology.

[9]  J. Mitchell,et al.  Treatment of murine intraperitoneal ovarian ascitic tumor with hematoporphyrin derivative and laser light. , 1985, Cancer research.

[10]  J. Kennedy,et al.  INTRAUTERINE 5‐AMINOLEVULINIC ACID INDUCES SELECTIVE FLUORESCENCE AND PHOTODYNAMIC ABLATION OF THE RAT ENDOMETRIUM * , 1993, Photochemistry and photobiology.

[11]  C. Wilson,et al.  Photodynamic therapy of malignant tumours. , 1972, Lancet.

[12]  H Stepp,et al.  Assessment of 5-aminolevulinic acid-induced porphyrin fluorescence in patients with peritoneal endometriosis. , 2000, American journal of obstetrics and gynecology.

[13]  M W Berns,et al.  Selective photosensitizer distribution in vulvar condyloma acuminatum after topical application of 5-aminolevulinic acid. , 1996, American journal of obstetrics and gynecology.

[14]  J. Kennedy,et al.  Fluorescence and photosensitization of experimental endometriosis in the rat after systemic 5-aminolevulinic acid administration: a potential new approach to the diagnosis and treatment of endometriosis. , 2011, American journal of obstetrics and gynecology.

[15]  T J Dougherty,et al.  Activated dyes as antitumor agents. , 1974, Journal of the National Cancer Institute.

[16]  T. Hasan,et al.  Photoimmunotherapy and biodistribution with an OC125-chlorin immunoconjugate in an in vivo murine ovarian cancer model. , 1994, British Journal of Cancer.

[17]  D. Harris,et al.  Photodynamic Therapy for Cancer of the Lower Female Genital Tract , 1986 .

[18]  Pratt Jh,et al.  HEMATOPORPHYRINE DERIVATIVE FOR DETECTION OF CERVICAL CANCER. , 1964 .

[19]  M W Berns,et al.  Benzoporphyrin Derivative: A Potent Photosensitizer for Photodynamic Destruction of Rabbit Endometrium , 1994, Obstetrics and gynecology.

[20]  M. Sturm,et al.  Brief communication: Unusual interaction between plasma membranes of cells in immunoelectron microscopy. , 1973, Journal of the National Cancer Institute.

[21]  Raymond Bonnett,et al.  Photosensitizers of the porphyrin and phthalocyanine series for photodynamic therapy , 1995 .

[22]  M. Berns,et al.  Accumulation of 5-aminolevulinic acid-induced protoporphyrin IX in normal and neoplastic human endometrial epithelial cells. , 1996, Biochemical and biophysical research communications.

[23]  R. Lipson,et al.  Hematoporphyrin-derivative-fluorescence test colposcopy and colpophotography in the diagnosis of atypical metaplasia, dysplasia, and carcinoma in situ of the cervix uteri. , 1973, American journal of obstetrics and gynecology.

[24]  George Davey Smith,et al.  Are we really dying for a tan? , 1999, BMJ.

[25]  M. Sakamoto,et al.  [Photodynamic therapy (PDT) for early cervical cancer]. , 1996, Gan to kagaku ryoho. Cancer & chemotherapy.

[26]  T. Dougherty Photodynamic therapy (PDT) of malignant tumors. , 1984, Critical reviews in oncology/hematology.

[27]  C. Whitehurst,et al.  Photodynamic treatment for lower genital tract intraepithelial neoplasia , 1998, The Lancet.

[28]  Richard L. Lipson,et al.  Hematoporphyrin derivative for detection and management of cancer , 1965, Cancer.

[29]  P. Rowe Photodynamic therapy begins to shine , 1998, The Lancet.

[30]  Stanley B. Brown,et al.  PDT of the endometrium using ALA , 1997, Photonics West - Biomedical Optics.

[31]  J C Kennedy,et al.  Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy. , 1992, Journal of photochemistry and photobiology. B, Biology.

[32]  M Korell,et al.  Photodynamic therapy of vulvar lichen sclerosus with 5-aminolevulinic acid. , 1999, Obstetrics and gynecology.

[33]  M J Manyak,et al.  Fluorescent detection of rabbit endometrial implants resulting from monodispersed viable cell suspensions. , 1990, Fertility and sterility.

[34]  F. Figge,et al.  Cancer Detection and Therapy. Affinity of Neoplastic, Embryonic, and Traumatized Tissues for Porphyrins and Metalloporphyrins.∗ , 1948, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[35]  T. Dougherty,et al.  HOW DOES PHOTODYNAMIC THERAPY WORK? , 1992, Photochemistry and photobiology.

[36]  J. Kennedy,et al.  Photodynamic therapy (PDT) and photodiagnosis (PD) using endogenous photosensitization induced by 5-aminolevulinic acid (ALA): mechanisms and clinical results. , 1996, Journal of clinical laser medicine & surgery.

[37]  Michael Barnett,et al.  Proceedings of the Society of Photo-Optical Instrumentation Engineers , 1975 .

[38]  J C Kennedy,et al.  Evidence of lasting functional destruction of the rat endometrium after 5-aminolevulinic acid-induced photodynamic ablation: prevention of implantation. , 1993, American journal of obstetrics and gynecology.

[39]  P A Cowled,et al.  Ablation of endometriotic implants in rabbits by hematoporphyrin derivative photoradiation therapy using the gold vapor laser , 1990, Lasers in surgery and medicine.

[40]  Mark R. Stringer,et al.  Light delivery schemes for uterine photodynamic therapy , 1994, Other Conferences.

[41]  Helmut F. Schellhas,et al.  Hematoporphyrin Derivative Uptake in Uteri of Estrogen-Treated Ovariectomized Rats , 1988 .

[42]  Leslie Anne Sabiniano,et al.  In vivo detection of metastatic ovarian cancer by means of 5-aminolevulinic acid-induced fluorescence in a rat model. , 1998, The Journal of the American Association of Gynecologic Laparoscopists.

[43]  Helmut F. Schellhas,et al.  Endometrial Ablation by DHE Photoradiation Therapy in Estrogen-Treated Ovariectomized Rats , 1988 .

[44]  M. Manyak,et al.  Photodynamic therapy of rabbit endometrial transplants: a model for treatment of endometriosis. , 1989, Fertility and sterility.

[45]  M Korell,et al.  Pharmacokinetics and selectivity of aminolevulinic acid–induced porphyrin synthesis in patients with cervical intra‐epithelial neoplasia , 1998, International journal of cancer.

[46]  R. Anderson,et al.  TRANSMITTANCE OF NONIONIZING RADIATION IN HUMAN TISSUES * , 1981, Photochemistry and photobiology.

[47]  M Korell,et al.  Photodynamic therapy in women with cervical intraepithelial neoplasia using topically applied 5‐aminolevulinic acid , 1999, International journal of cancer.

[48]  D. Dolphin,et al.  Porphyrin-Based Photosensitizers for Use in Photodynamic Therapy , 1998 .

[49]  R. Lilford,et al.  Photosensitization of the endometrium with topical 5-aminolevulinic acid. , 1995, American journal of obstetrics and gynecology.

[50]  M. Cooney,et al.  History of photodynamic therapy. , 1999, International ophthalmology clinics.

[51]  B. Ward,et al.  The treatment of vaginal recurrences of gynecologic malignancy with phototherapy following hematoporphyrin derivative pretreatment. , 1982, American journal of obstetrics and gynecology.

[52]  R. Schenken,et al.  Laser-Induced Fluorescence of Ectopic Endometrium in Rabbits , 1989, Obstetrics and gynecology.

[53]  Richard L. Lipson,et al.  Transactions of the Ninetieth Annual Meeting of the American Gynecological Society—continuedUse of hematoporphyrin derivative in detection and management of cervical cancer: A preliminary report☆☆☆ , 1967 .

[54]  L. O. Svaasand,et al.  Intrauterine light delivery for photodynamic therapy of the human endometrium. , 1995, Human reproduction.

[55]  J. Hill,et al.  A history of photodynamic therapy. , 1991, The Australian and New Zealand journal of surgery.

[56]  A. M. Olsen,et al.  The use of a derivative of hematoporphyrin in tumor detection. , 1961 .

[57]  F. Wierrani,et al.  Clinical effect of meso‐tetrahydroxyphenylchlorine based photodynamic therapy in recurrent carcinoma of the ovary: preliminary results , 1997, British journal of obstetrics and gynaecology.

[58]  R. G. Frank,et al.  Photodynamic therapy for condylomata acuminata with local application of 5-aminolevulinic acid. , 1996, Genitourinary medicine.

[59]  M W Berns,et al.  Photomedicine of the endometrium: experimental concepts. , 1995, Human reproduction.

[60]  Ethan Sternberg,et al.  Porphyrin-based photosensitizers for use in photodynamic therapy , 1998 .

[61]  S. Steinberg,et al.  Phase I study of debulking surgery and photodynamic therapy for disseminated intraperitoneal tumors. , 1993, International journal of radiation oncology, biology, physics.

[62]  H Stepp,et al.  Detection of early bladder cancer by 5-aminolevulinic acid induced porphyrin fluorescence. , 1996, The Journal of urology.

[63]  H. Schellhas,et al.  Photodynamic therapy of gynecologic neoplasms after presensitization with hematoporphyrin derivative , 1985, Lasers in surgery and medicine.

[64]  J E Kaufman,et al.  Photoradiation therapy for the treatment of malignant tumors. , 1978, Cancer research.

[65]  T. Dougherty Photodynamic therapy. , 1993, Photochemistry and photobiology.

[66]  M J Gray,et al.  Use of hematoporphyrin derivative in detection and management of cervical cancer. , 1967, American journal of obstetrics and gynecology.

[67]  T Hasan,et al.  Endometrial ablation by means of photodynamic therapy with photofrin II. , 1992, American journal of obstetrics and gynecology.

[68]  M W Berns,et al.  Effect of administration route and estrogen manipulation on endometrial uptake of Photofrin porfimer sodium. , 1993, American journal of obstetrics and gynecology.