Improvement in dynamic range limitation of swept source optical coherence tomography by true logarithmic amplification.

We previously demonstrated, with both theoretical and experimental studies, the dynamic range limitation with spectral domain optical coherence tomography (OCT) relative to time domain OCT. A significant portion of this limitation was due to the difference of analog/digital conversion. In this paper, a new method of true logarithmic amplification is discussed theoretically and tested experimentally to increase the dynamic range of a swept source OCT. With the current experimental setup, an increase of the dynamic range by about 6 dB was obtained.

[1]  S. Boppart Surgical diagnostics, guidance, and intervention using optical coherence tomography , 1998 .

[2]  J. Fujimoto,et al.  In vivo endoscopic optical biopsy with optical coherence tomography. , 1997, Science.

[3]  J. Fujimoto,et al.  Optical coherence tomography for optical biopsy. Properties and demonstration of vascular pathology. , 1996, Circulation.

[4]  A. Fercher,et al.  Performance of fourier domain vs. time domain optical coherence tomography. , 2003, Optics express.

[5]  Bin Liu,et al.  Nonlocal quantum macroscopic superposition in a high-thermal low-purity state. , 2008, Physical review. A, Atomic, molecular, and optical physics.

[6]  Changhuei Yang,et al.  Sensitivity advantage of swept source and Fourier domain optical coherence tomography. , 2003, Optics express.

[7]  S. Yun,et al.  115 kHz tuning repetition rate ultrahigh-speed wavelength-swept semiconductor laser. , 2005, Optics letters.

[8]  Chi-Hau Chen Signal-to-noise ratios in logarithmic amplifiers , 1969 .

[9]  Guillermo J. Tearney Optical biopsy of in vivo tissue using optical coherence tomography , 1996 .

[10]  Franco Giannini,et al.  Theory and performance of parabolic true logarithmic amplifier , 1997 .

[11]  A. Fercher,et al.  Measurement of intraocular distances by backscattering spectral interferometry , 1995 .

[12]  Bin Liu,et al.  Theoretical and practical considerations on detection performance of time domain, Fourier domain, and swept source optical coherence tomography. , 2007, Journal of biomedical optics.

[13]  B. Bouma,et al.  Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography. , 2003, Optics letters.

[14]  B. Loesch A UHF True Logarithmic IF Amplifier , 1973, IEEE Transactions on Aerospace and Electronic Systems.

[15]  J. Fujimoto,et al.  Buffered Fourier domain mode locking: Unidirectional swept laser sources for optical coherence tomography imaging at 370,000 lines/s. , 2006, Optics letters.

[16]  G. Ha Usler,et al.  "Coherence radar" and "spectral radar"-new tools for dermatological diagnosis. , 1998, Journal of biomedical optics.

[17]  J. Croney,et al.  A true i.f. logarithmic amplifier using twin-gain stages , 1966 .

[18]  T. Mitsui,et al.  Dynamic Range of Optical Reflectometry with Spectral Interferometry , 1999 .

[19]  R. Leitgeb,et al.  High speed full range complex spectral domain optical coherence tomography. , 2005, Optics express.

[20]  S. Yun,et al.  In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve. , 2004, Optics express.

[21]  J. Schuman,et al.  Optical coherence tomography. , 2000, Science.

[22]  J. Fujimoto,et al.  Optical coherence tomography using a frequency-tunable optical source. , 1997, Optics letters.

[23]  Bin Liu,et al.  Experimental confirmation of potential swept source optical coherence tomography performance limitations. , 2008, Applied optics.

[24]  James G. Fujimoto,et al.  Optical coherence tomography: high-resolution imaging in nontransparent tissue , 1999 .