Pseudoxanthoma elasticum‐like changes in nonuremic calciphylaxis: Case series and brief review of a helpful diagnostic clue

Calciphylaxis is a rare syndrome of vascular calcification with thrombosis that occurs most often in patients with end‐stage renal disease, and it frequently portends a guarded prognosis. Rarely, nonuremic calciphylaxis (NUC) may occur; in this context, a strongly supportive histology is crucial in establishing the diagnosis. Herein, we describe 2 cases of NUC associated with pseudoxanthoma elasticum‐like changes, identified in both initial nondiagnostic and subsequent diagnostic biopsy specimens. This unusual but helpful histologic finding may support the early diagnosis and treatment of a potentially life‐threatening disease in the context of subtle histopathologic vascular changes or in the absence of classic clinical or laboratory findings.