Ameliorative effects of mangiferin derivative TPX on insulin resistance via PI3K/AKT and AMPK signaling pathways in human HepG2 and HL-7702 hepatocytes.

[1]  Hu Zhou,et al.  Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1 , 2023, Signal Transduction and Targeted Therapy.

[2]  Xincong Kang,et al.  The glucotoxicity protecting effect of honokiol in human hepatocytes via directly activating AMPK , 2022, Frontiers in Nutrition.

[3]  D. Hardie,et al.  New insights into activation and function of the AMPK , 2022, Nature Reviews Molecular Cell Biology.

[4]  Xianming Deng,et al.  The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK , 2022, Nature Metabolism.

[5]  Pei Xu,et al.  PACAP attenuates hepatic lipid accumulation through the FAIM/AMPK/IRβ axis during overnutrition , 2022, Molecular metabolism.

[6]  Hanmei Xu,et al.  Trends in insulin resistance: insights into mechanisms and therapeutic strategy , 2022, Signal Transduction and Targeted Therapy.

[7]  J. Zou,et al.  Aberrant HSF1 signaling activation underlies metformin amelioration of myocardial infarction in mice , 2022, Molecular therapy. Nucleic acids.

[8]  M. Fu,et al.  A diarylheptanoid compound from Alpinia officinarum Hance ameliorates high glucose-induced insulin resistance by regulating PI3K/AKT-Nrf2-GSK3β signaling pathways in HepG2 cells. , 2022, Journal of ethnopharmacology.

[9]  C. Myung,et al.  Garcinia Cambogia Improves High-Fat Diet-Induced Glucose Imbalance By Enhancing Calcium/CaMKII/AMPK/GLUT4-Mediated Glucose Uptake In Skeletal Muscle. , 2022, Molecular nutrition & food research.

[10]  Yan Liang,et al.  The management of diabetes mellitus by mangiferin: advances and prospects. , 2022, Nanoscale.

[11]  R. DeFronzo,et al.  Insulin: The master regulator of glucose metabolism. , 2022, Metabolism: clinical and experimental.

[12]  Yan Yang,et al.  Gentiopicroside targets PAQR3 to activate the PI3K/AKT signaling pathway and ameliorate disordered glucose and lipid metabolism , 2022, Acta pharmaceutica Sinica. B.

[13]  Dong Wang,et al.  Dendrocalamus latiflorus and its component rutin exhibit glucose-lowering activities by inhibiting hepatic glucose production via AKT activation , 2021, Acta pharmaceutica Sinica. B.

[14]  Haile Ma,et al.  Mangiferin: a review of dietary sources, absorption, metabolism, bioavailability, and safety. , 2021, Critical reviews in food science and nutrition.

[15]  Yongqiang Wang,et al.  Fructose‐1,6‐Bisphosphate Aldolase B Depletion Promotes Hepatocellular Carcinogenesis Through Activating Insulin Receptor Signaling and Lipogenesis , 2021, Hepatology.

[16]  D. James,et al.  The aetiology and molecular landscape of insulin resistance , 2021, Nature Reviews Molecular Cell Biology.

[17]  Nuo Xu,et al.  Chrysin Improves Glucose and Lipid Metabolism Disorders by Regulating the AMPK/PI3K/AKT Signaling Pathway in Insulin-Resistant HepG2 Cells and HFD/STZ-Induced C57BL/6J Mice. , 2021, Journal of agricultural and food chemistry.

[18]  C. Xing,et al.  Comparative efficacy of oral insulin sensitizers metformin, thiazolidinediones, inositol, and berberine in improving endocrine and metabolic profiles in women with PCOS: a network meta-analysis , 2021, Reproductive Health.

[19]  Zhi Li,et al.  Metformin protects against insulin resistance induced by high uric acid in cardiomyocytes via AMPK signalling pathways in vitro and in vivo , 2021, bioRxiv.

[20]  Wei Li,et al.  S-Allylmercaptocysteine improves alcoholic liver disease partly through a direct modulation of insulin receptor signaling , 2020, Acta pharmaceutica Sinica. B.

[21]  Fatma S. A. Saadeldeen,et al.  Natural products: Regulating glucose metabolism and improving insulin resistance , 2020, Food Science and Human Wellness.

[22]  Li Fang,et al.  Peptides from walnut (Juglans mandshurica Maxim.) protect hepatic HepG2 cells from high glucose-induced insulin resistance and oxidative stress. , 2020, Food & function.

[23]  Min Wang,et al.  Polyphenol-rich extract of Zhenjiang aromatic vinegar ameliorates high glucose-induced insulin resistance by regulating JNK-IRS-1 and PI3K/Akt signaling pathways. , 2020, Food chemistry.

[24]  Shijie Cao,et al.  Curcumin metabolites contribute to the effect of curcumin on ameliorating insulin sensitivity in high-glucose-induced insulin-resistant HepG2 cells. , 2020, Journal of ethnopharmacology.

[25]  S. Rahman,et al.  Mangiferin induces the expression of a thermogenic signature via AMPK signaling during brown-adipocyte differentiation. , 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[26]  Yan Guo,et al.  Identification of endogenous 1‐aminopyrene as a novel mediator of progressive chronic kidney disease via aryl hydrocarbon receptor activation , 2020, British journal of pharmacology.

[27]  H. Lebovitz.  Thiazolidinediones: the Forgotten Diabetes Medications , 2019, Current Diabetes Reports.

[28]  B. Viollet,et al.  Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus , 2019, Nature Reviews Endocrinology.

[29]  J. Zhao,et al.  Therapeutic Mechanisms of Herbal Medicines Against Insulin Resistance: A Review , 2019, Front. Pharmacol..

[30]  Radhika S. Khetani,et al.  Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression , 2019, Cell.

[31]  H. Hosseinzadeh,et al.  Berberine and barberry (Berberis vulgaris): A clinical review , 2019, Phytotherapy research : PTR.

[32]  Rongsheng Tong,et al.  Mangiferin: An effective therapeutic agent against several disorders (Review). , 2018, Molecular medicine reports.

[33]  G. Shulman,et al.  Mechanisms of Insulin Action and Insulin Resistance. , 2018, Physiological reviews.

[34]  Guihua Liu,et al.  The PI3K/AKT pathway in obesity and type 2 diabetes , 2018, International journal of biological sciences.

[35]  B. Viollet,et al.  Promise and challenges for direct small molecule AMPK activators , 2018, Biochemical pharmacology.

[36]  Weimin Li,et al.  Astragaloside IV Inhibits Triglyceride Accumulation in Insulin-Resistant HepG2 Cells via AMPK-Induced SREBP-1c Phosphorylation , 2018, Front. Pharmacol..

[37]  Yi Zhang,et al.  Mangiferin Improves Hepatic Lipid Metabolism Mainly Through Its Metabolite-Norathyriol by Modulating SIRT-1/AMPK/SREBP-1c Signaling , 2018, Front. Pharmacol..

[38]  Ivana V. Yang,et al.  Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants , 2017, Molecular metabolism.

[39]  Yeji Kim,et al.  AMPK activators: mechanisms of action and physiological activities , 2016, Experimental & Molecular Medicine.

[40]  Hongliang Li,et al.  Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling , 2016, Nature Communications.

[41]  Honggang Hu,et al.  X-3, a mangiferin derivative, stimulates AMP-activated protein kinase and reduces hyperglycemia and obesity in db/db mice , 2015, Molecular and Cellular Endocrinology.

[42]  C. Palmer,et al.  Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study , 2014, Diabetes.

[43]  G. Shulman,et al.  Mechanisms for Insulin Resistance: Common Threads and Missing Links , 2012, Cell.

[44]  Mengwei Zang,et al.  AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. , 2011, Cell metabolism.