Active site-directed thrombin inhibitors: alpha-hydroxyacyl-prolyl-arginals. New orally active stable analogs of D-Phe-Pro-Arg-H.

[1]  S. Bajusz,et al.  Screening for fibrinolysis inhibitory effect of synthetic thrombin inhibitors , 1993, Blood Coagulation and Fibrinolysis.

[2]  Charles S. Campbell,et al.  Highly selective tripeptide thrombin inhibitors. , 1993, Journal of Medicinal Chemistry.

[3]  N. Meanwell,et al.  Active site-directed synthetic thrombin inhibitors: synthesis, in vitro and in vivo activity profile of BMY 44621 and analogs. An examination of the role of the amino group in the D-Phe-Pro-Arg-H series. , 1993, Journal of Medicinal Chemistry.

[4]  S. Bajusz,et al.  Inhibition by D-MePhe-Pro-Arg-H (GYKI-14766) of Thrombus Growth in Experimental Models of Thrombosis , 1992, Thrombosis and Haemostasis.

[5]  S. Bajusz,et al.  In Vitro Inhibition of Blood Coagulation by Tripeptide Aldehydes - A Retrospective Screening Study Focused on the Stable D-MePhe-Pro-Arg-H · H2SO4 , 1992, Thrombosis and Haemostasis.

[6]  S. Bajusz,et al.  In Vivo Anticoagulant and Antiplatelet Effect of D-Phe-Pro-Arg-H and D-MePhe-Pro-Arg-H , 1992, Thrombosis and Haemostasis.

[7]  G. Claeson,et al.  Substrate-related phosphonopeptides, a new class of thrombin inhibitors , 1991 .

[8]  M. Dioszegi,et al.  Highly active and selective anticoagulants: D-Phe-Pro-Arg-H, a free tripeptide aldehyde prone to spontaneous inactivation, and its stable N-methyl derivative, D-MePhe-Pro-Arg-H. , 1990, Journal of medicinal chemistry.

[9]  Garland R. Marshall,et al.  Peptides: Chemistry, Structure and Biology , 1990 .

[10]  R. Huber,et al.  The refined 1.9 A crystal structure of human alpha‐thrombin: interaction with D‐Phe‐Pro‐Arg chloromethylketone and significance of the Tyr‐Pro‐Pro‐Trp insertion segment. , 1989, The EMBO journal.

[11]  P. Cordopatis,et al.  Convenient synthesis of n-trityl-o-alkyl-l-hydroxyamino acids and derivatives : Application to the synthesis of related peptides , 1983 .

[12]  G. Avery.  Drug treatment : principles and practice of clinical pharmacology and therapeutics , 1980 .

[13]  S. Bajusz,et al.  Inhibition of thrombin and trypsin by tripeptide aldehydes. , 2009, International journal of peptide and protein research.

[14]  L. Gráf,et al.  A superactive antinociceptive pentapeptide, (D‐Met2,Pro5)‐enkephalinamide , 1977, FEBS letters.

[15]  N. Izumiya,et al.  Studies on Diastereoisomeric α-Amino Acids and Corresponding α-Hydroxy Acids. VII. Influence of β-Configuration on Enzymic Susceptibility , 1956 .