Biotin and carnitine profiles in preterm infants in Japan

Biotin plays an important role as a covalently bound coenzyme for carboxylases. Carnitine is essential in β‐oxidation to transport long‐chain fatty acids across the inner mitochondrial membrane. The present study was conducted to assess the risk of biotin and carnitine deficiencies in preterm infants who received enteral feeding with maternal milk and/or standard infant formula made in Japan.

[1]  D. Mock,et al.  Plasma concentration of 3-hydroxyisovaleryl carnitine is an early and sensitive indicator of marginal biotin deficiency in humans. , 2010, The American journal of clinical nutrition.

[2]  Y. Shigematsu,et al.  Useful second-tier tests in expanded newborn screening of isovaleric acidemia and methylmalonic aciduria , 2010, Journal of Inherited Metabolic Disease.

[3]  T. Kanno,et al.  Fat-soluble and water-soluble vitamin contents of breast milk from Japanese women. , 2005, Journal of nutritional science and vitaminology.

[4]  L. Brion,et al.  Lack of Effect of L-Carnitine Supplementation on Weight Gain in Very Preterm Infants , 2005, Journal of Perinatology.

[5]  D. Millington,et al.  Evaluation of 3-methylcrotonyl-CoA carboxylase deficiency detected by tandem mass spectrometry newborn screening , 2003, Journal of Inherited Metabolic Disease.

[6]  R. Mcmahon.  Biotin in metabolism and molecular biology. , 2002, Annual review of nutrition.

[7]  N. Longo,et al.  Primary and secondary alterations of neonatal carnitine metabolism. , 1999, Seminars in perinatology.

[8]  T. Watanabe,et al.  Low biotin content of infant formulas made in Japan. , 1998, Food additives and contaminants.

[9]  J. Wesley,et al.  Biotin deficiency in a patient with short bowel syndrome during home parenteral nutrition. , 1984, JPEN. Journal of parenteral and enteral nutrition.

[10]  J. Shenai,et al.  Tissue Carnitine Reserves of Newborn Infants , 1984, Pediatric Research.

[11]  J. Bremer.  Carnitine--metabolism and functions. , 1983, Physiological reviews.

[12]  C. Angelini,et al.  Plasma and Urine Carnitine Levels During Development , 1980, Pediatric Research.

[13]  C. Rebouche,et al.  Significance of renal gamma-butyrobetaine hydroxylase for carnitine biosynthesis in man. , 1980, The Journal of biological chemistry.

[14]  O. L. Kline,et al.  Commentary on breast-feeding and infant formulas, including proposed standards for formulas. , 1976, Pediatrics.