Nano-functionalized long-period fiber grating probe for disease-specific protein detection.

Optical biosensors have great significance for rapid and sensitive detection and monitoring of biomolecular interactions. Here, recent advancement in the nano-functionalized long-period fiber grating (LPFG) is used to develop a cost-effective approach for label-free and real-time detection of the carbonic anhydrase-IX (CA9) monoclonal antibody, a diagnostic biomarker in hypoxia condition cultured carcinoma cells.

[1]  J. Pastorek,et al.  Carbonic anhydrase IX is a clinically significant tissue and serum biomarker associated with renal cell carcinoma. , 2013, Oncology letters.

[2]  Alaaldin M. Alkilany,et al.  Colloidal stability of citrate and mercaptoacetic acid capped gold nanoparticles upon lyophilization: effect of capping ligand attachment and type of cryoprotectants. , 2014, Langmuir : the ACS journal of surfaces and colloids.

[3]  Javad Zahiri,et al.  Computational Prediction of Protein–Protein Interaction Networks: Algo-rithms and Resources , 2013, Current genomics.

[4]  J S Sirkis,et al.  Evanescent wave long-period fiber bragg grating as an immobilized antibody biosensor. , 2000, Analytical chemistry.

[5]  X. Qu,et al.  Cancer biomarker detection: recent achievements and challenges. , 2015, Chemical Society reviews.

[6]  Juan Ignacio Godino-Llorente,et al.  Voice Pathology Detection Using Modulation Spectrum-Optimized Metrics , 2016, Front. Bioeng. Biotechnol..

[7]  F. U. Hernandez,et al.  Highly sensitive optical fibre long period grating biosensor anchored with silica core gold shell nanoparticles. , 2016, Biosensors & bioelectronics.

[8]  L. Chau,et al.  Colloidal gold-modified optical fiber for chemical and biochemical sensing. , 2003, Analytical chemistry.

[9]  Jaw-Luen Tang,et al.  Chemical Sensing Sensitivity of Long-Period Grating Sensor Enhanced by Colloidal Gold Nanoparticles , 2008, Sensors.

[10]  T Kobayashi,et al.  Local plasmon sensor with gold colloid monolayers deposited upon glass substrates. , 2000, Optics letters.

[11]  Donna Richardson,et al.  Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[12]  Antonello Cutolo,et al.  Long period fiber grating working in reflection mode as valuable biosensing platform for the detection of drug resistant bacteria , 2016 .

[13]  T. Okamoto,et al.  Absorption spectrum of surface-bound cap-shaped gold particles. , 2002, Optics letters.

[14]  Antonello Cutolo,et al.  Long period fiber grating nano-optrode for cancer biomarker detection. , 2016, Biosensors & bioelectronics.

[15]  W. Wilson,et al.  Targeting hypoxia in cancer therapy , 2011, Nature Reviews Cancer.

[16]  H. Minn,et al.  Expression of carbonic anhydrase IX suggests poor outcome in rectal cancer , 2009, British Journal of Cancer.

[17]  K. Milde-Langosch,et al.  Carbonic anhydrase IX in tumor tissue and sera of patients with primary cervical cancer , 2011, BMC Cancer.

[18]  Jaw-Luen Tang,et al.  Fiber-optic biochemical sensing with a colloidal gold-modified long period fiber grating , 2006 .

[19]  J. Pastorek,et al.  Carbonic anhydrase IX: regulation and role in cancer. , 2014, Sub-cellular biochemistry.

[20]  Anna Zhu,et al.  Recent Advances in Optical Biosensors for Environmental Monitoring and Early Warning , 2013, Sensors.

[21]  J. Pastorek,et al.  Hypoxia-induced carbonic anhydrase IX as a target for cancer therapy: from biology to clinical use. , 2015, Seminars in cancer biology.

[22]  R. Gillies,et al.  Evaluation of CAIX and CAXII Expression in Breast Cancer at Varied O2 Levels: CAIX is the Superior Surrogate Imaging Biomarker of Tumor Hypoxia , 2016, Molecular Imaging and Biology.

[23]  Tingting Lang,et al.  Label-free fiber optic biosensor based on thin-core modal interferometer , 2016 .

[24]  David J. Mooney,et al.  Label-free biomarker detection from whole blood , 2009, 2010 10th IEEE International Conference on Solid-State and Integrated Circuit Technology.

[25]  Hanlee P. Ji,et al.  Multiplexed protein detection by proximity ligation for cancer biomarker validation , 2007, Nature Methods.

[26]  Jacques Albert,et al.  Improved detection limits of protein optical fiber biosensors coated with gold nanoparticles. , 2014, Biosensors & bioelectronics.

[27]  J. Pouysségur,et al.  High levels of carbonic anhydrase IX in tumour tissue and plasma are biomarkers of poor prognostic in patients with non-small cell lung cancer , 2010, British Journal of Cancer.

[28]  Ulf Landegren,et al.  Sensitive protein detection via triple-binder proximity ligation assays , 2007, Nature Methods.

[29]  Marcus Schmidt,et al.  Relevance of cellular and serum carbonic anhydrase IX in primary breast cancer , 2013, Journal of Cancer Research and Clinical Oncology.

[30]  Y. Rao,et al.  Glass Structure Changes in CO$_{2}$ -Laser Writing of Long-Period Fiber Gratings in Boron-Doped Single-Mode Fibers , 2009, Journal of Lightwave Technology.

[31]  C. Zhiqiang,et al.  Detection of embryonic stem cell lysate biomarkers by surface plasmon resonance with reduced nonspecific adsorption. , 2015, Analytical biochemistry.

[32]  Ming Zhou,et al.  Quantification of carbonic anhydrase IX expression in serum and tissue of renal cell carcinoma patients using enzyme-linked immunosorbent assay: prognostic and diagnostic potentials. , 2010, Urology.

[33]  F. Baldini,et al.  Sol-Gel-Based Titania-Silica Thin Film Overlay for Long Period Fiber Grating-Based Biosensors. , 2015, Analytical chemistry.

[34]  S. Dedhar,et al.  Carbonic anhydrase IX (CAIX) as a mediator of hypoxia-induced stress response in cancer cells. , 2014, Sub-cellular biochemistry.

[35]  K. Chiang,et al.  Wide-Range pH Sensor Based on a Smart- Hydrogel-Coated Long-Period Fiber Grating , 2017, IEEE Journal of Selected Topics in Quantum Electronics.