Injection device with secure knob

The present invention relates to an injection device comprising: a receiving device for a substance to be delivered, in particular an ampoule holder (1) which is movable relative to the injection device or a part thereof; an adjusting member (6) for setting a dispensed dose from the injection device, which is inserted in the injection device; and the adjustment member (6) can at least be pushed out part to the injection device a coupling element (5) for coupling the receiving device (1) with the adjusting element (6), so that an insertion movement of the receiving device (1), and a process for preparing an injection device for delivering a substance with an adjusting device (6) which is enabled only during or after a mixing procedure of a two-chamber ampoule (2) or is extended from the injection device or ejected.