A NOVEL CHROMATOGRAPHY FORMAT FOR HIGH EFFICIENCY SEPARATIONS

A non-porous C8 coated silicon pillar channel design is presented that allows the achievement of a high pressure and high efficiency operation for HPLC separations. Performing on-chip injection and detection and hence omitting the related dispersive sources, more than one million theoretical plates were obtained in non-retained conditions. The performance potential was also demonstrated by connecting the column to a commercial capillary HPLC system and injecting and detecting (UVVis) sample plugs off-chip.