Motion-insensitive optical coherence tomography based micro-angiography.

An improved image processing procedure for suppressing the phase noise due to a motion artifact acquired during optical coherence tomography scanning and effectively illustrating the blood vessel distribution in a living tissue is demonstrated. This new processing procedure and the widely used procedure for micro-angiography application are based on the selection of high-frequency components in the spatial-frequency spectrum of B-mode scanning (x-space), which are contributed from the image portions of moving objects. However, by switching the processing order between the x-space and k-space, the new processing procedure shows the superior function of effectively suppressing the phase noise due to a motion artifact. After the blood vessel positions are precisely acquired based on the new processing procedure, the projected blood flow speed can be more accurately calibrated based on a previously reported method. The demonstrated new procedure is useful for clinical micro-angiography application, in which a stepping motor of generating motion artifacts is usually used in the scanning probe.

[1]  K. Larin,et al.  Development of phase-stabilized swept-source OCT for the ultrasensitive quantification of microbubbles , 2008 .

[2]  Ruikang K. Wang,et al.  Volumetric and quantitative imaging of retinal blood flow in rats with optical microangiography , 2011, Biomedical optics express.

[3]  Brett E Bouma,et al.  Two-axis magnetically-driven MEMS scanning catheter for endoscopic high-speed optical coherence tomography. , 2007, Optics express.

[4]  Huikai Xie,et al.  3D in vivo optical coherence tomography based on a low-voltage, large-scan-range 2D MEMS mirror. , 2010, Optics express.

[5]  Zhongping Chen,et al.  Phase-resolved optical coherence tomography and optical Doppler tomography for imaging blood flow in human skin with fast scanning speed and high velocity sensitivity. , 2000, Optics letters.

[6]  M. V. van Gemert,et al.  Noninvasive imaging of in vivo blood flow velocity using optical Doppler tomography. , 1997, Optics letters.

[7]  Ruikang K. Wang,et al.  In vivo volumetric imaging of vascular perfusion within human retina and choroids with optical micro-angiography. , 2008, Optics express.

[8]  Hsiang-Chieh Lee,et al.  Effective indicators for diagnosis of oral cancer using optical coherence tomography. , 2008, Optics express.

[9]  M. Wojtkowski,et al.  Three-dimensional quantitative imaging of retinal and choroidal blood flow velocity using joint Spectral and Time domain Optical Coherence Tomography. , 2009, Optics express.

[10]  Martin F. Kraus,et al.  Total retinal blood flow measurement with ultrahigh speed swept source/Fourier domain OCT , 2011, Biomedical optics express.

[11]  Ruikang K. Wang,et al.  High-resolution wide-field imaging of retinal and choroidal blood perfusion with optical microangiography. , 2010, Journal of biomedical optics.

[12]  Ruikang K. Wang,et al.  Doppler optical micro-angiography for volumetric imaging of vascular perfusion in vivo. , 2009, Optics express.

[13]  Byeong Ha Lee,et al.  Enhanced imaging of choroidal vasculature by high-penetration and dual-velocity optical coherence angiography , 2011, Biomedical optics express.

[14]  Hsiang-Chieh Lee,et al.  Differentiating oral lesions in different carcinogenesis stages with optical coherence tomography. , 2009, Journal of biomedical optics.

[15]  J. Izatt,et al.  In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography. , 1997, Optics letters.

[16]  David Huang,et al.  Retinal blood flow detection in diabetic patients by Doppler Fourier domain optical coherence tomography. , 2009, Optics express.

[17]  Ruikang K. Wang,et al.  Real-time flow imaging by removing texture pattern artifacts in spectral-domain optical Doppler tomography. , 2006, Optics letters.

[18]  Ruikang K. Wang,et al.  Full range complex ultrahigh sensitive optical microangiography. , 2011, Optics letters.

[19]  Adrian Mariampillai,et al.  Interstitial Doppler optical coherence tomography as a local tumor necrosis predictor in photodynamic therapy of prostatic carcinoma: an in vivo study. , 2008, Cancer research.

[20]  Zhongping Chen,et al.  Optical Doppler tomographic imaging of fluid flow velocity in highly scattering media. , 1997, Optics letters.

[21]  T. Yatagai,et al.  Optical coherence angiography. , 2006, Optics express.

[22]  Jun Zhang,et al.  In vivo blood flow imaging by a swept laser source based Fourier domain optical Doppler tomography. , 2005, Optics express.

[23]  Ruikang K. Wang,et al.  Highly sensitive imaging of renal microcirculation in vivo using ultrahigh sensitive optical microangiography , 2011, Biomedical optics express.