Current advancement in immunosensing of p53 tumor suppressor protein based on nanomaterials: Analytical approach

Abstract The utility of detection of p53 in tomorrow's personalized health care field will mean early and accurate diagnosis of many types of cancers. This review is meant to provide an overview of the various types of immunosensors and immunoassay have been developed for determination of p53, along with significant advances over the last several years in related technologies. In addition, this review described: • Most frequently applied principles in immunoassay/immunosensing of p53. • The aspects of fabrication in the perspective of immunoassay/immunosensing applications. • The potential of various electrochemical, electrochemiluminescence immunosensors for the determination of p53 within sub-nanomolar range and the circumvention of the most serious problem in immunosensing will be discussed. • Some of multiplex electrochemical immunosensors have been discussed with and without labels. • We also summarize the latest developments in the applications of immunoassay/immunosensing methods for detection of p53 in real samples. • The development trends of electrochemical and electrochemiluminescence based immunosensors are also introduced, including newly developed integrated immunosensors, and the application of nanotechnology and microfluidic technology.

[1]  Dan Du,et al.  Functionalized graphene oxide as a nanocarrier in a multienzyme labeling amplification strategy for ultrasensitive electrochemical immunoassay of phosphorylated p53 (S392). , 2011, Analytical chemistry.

[2]  Alice Dohnalkova,et al.  Multiplexed electrochemical immunoassay of phosphorylated proteins based on enzyme-functionalized gold nanorod labels and electric field-driven acceleration. , 2011, Analytical chemistry.

[3]  John Mitchell,et al.  Small Molecule Immunosensing Using Surface Plasmon Resonance , 2010, Sensors.

[4]  Dan Du,et al.  Magnetic particle-based immunoassay of phosphorylated p53 using protein cage templated lead phosphate and carbon nanospheres for signal amplification , 2012 .

[5]  Xiaoying Wang,et al.  The enzyme electrocatalytic immunosensor based on functional composite nanofibers for sensitive detection of tumor suppressor protein p53 , 2015 .

[6]  L. Shulman,et al.  Mutant p53 protein in serum could be used as a molecular marker in human breast cancer. , 2006, International journal of oncology.

[7]  Mohamed A El Far,et al.  Evaluation of serum levels of p53 in hepatocellular carcinoma in Egypt , 2006, Clinical chemistry and laboratory medicine.

[8]  Wei Wen,et al.  Recent Advances in Electrochemical Immunosensors. , 2017, Analytical chemistry.

[9]  Ying Zhuo,et al.  Electrochemiluminescence Sensor Based on Multiwalled Carbon Nanotubes Doped Polyvinyl Butyral Film Containing Ru(bpy)$\rm{ {_{3}^{2+}}}$ as Chemiluminescence Reagent , 2009 .

[10]  James F Rusling,et al.  Nanomaterials-based electrochemical immunosensors for proteins. , 2012, Chemical record.

[11]  Claude Granier,et al.  Detection of anti-p53 antibodies by ELISA using p53 synthetic or phage-displayed peptides. , 2002, Journal of immunological methods.

[12]  D. Wild.  The Immunoassay Handbook , 2001 .

[13]  M. Blagosklonny,et al.  P53: An ubiquitous target of anticancer drugs , 2002, International journal of cancer.

[14]  Won-Yong Lee,et al.  Tris(2,2'-bipyridyl)ruthenium(ii) electrogenerated chemiluminescence sensor based on platinized carbon nanotube-zirconia-nafion composite films , 2010 .

[15]  T. Strachan,et al.  Human Molecular Genetics 2 , 1997 .

[16]  Mohammad Hasanzadeh,et al.  Electrochemical and photoelectrochemical nano-immunesensing using origami paper based method. , 2016, Materials science & engineering. C, Materials for biological applications.

[17]  Mohammad Hasanzadeh,et al.  Electrochemical nano-immunosensing of effective cardiac biomarkers for acute myocardial infarction , 2013 .

[18]  D. Chan,et al.  Immunosensors--principles and applications to clinical chemistry. , 2001, Clinica chimica acta; international journal of clinical chemistry.

[19]  Mohamed Siaj,et al.  Au nanoparticle decorated graphene nanosheets for electrochemical immunosensing of p53 antibodies for cancer prognosis. , 2016, The Analyst.

[20]  Mohammad Hasanzadeh,et al.  Iron and iron-oxide magnetic nanoparticles as signal-amplification elements in electrochemical biosensing , 2015 .

[21]  Mohammad Hasanzadeh,et al.  Mesoporous silica-based materials for use in electrochemical enzyme nanobiosensors , 2012 .

[22]  S. Campuzano,et al.  Dual functional graphene derivative-based electrochemical platforms for detection of the TP53 gene with single nucleotide polymorphism selectivity in biological samples. , 2015, Analytical chemistry.

[23]  K. Dameron,et al.  Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. , 1994, Science.

[24]  Mohammad Hasanzadeh,et al.  Mesoporous silica-based materials for use in biosensors , 2012 .

[25]  P Sismondi,et al.  Immunofluorometrically determined p53 accumulation as a prognostic indicator in italian breast cancer patients , 1998, International journal of cancer.

[26]  Qing Chen,et al.  Serum p53 protein and anti-p53 antibodies are associated with increased cancer risk: a case–control study of 569 patients and 879 healthy controls , 2009, Molecular Biology Reports.

[27]  M. Ramezani,et al.  Two dimension (2-D) graphene-based nanomaterials as signal amplification elements in electrochemical microfluidic immune-devices: Recent advances. , 2016, Materials science & engineering. C, Materials for biological applications.

[28]  Carissa A. Sanchez,et al.  Inactivation of p53 and the Development of Tetraploidy in the Elastase‐SV40 T Antigen Transgenic Mouse Pancreas , 1995, Pancreas.

[29]  Danny K.Y. Wong,et al.  Strategic Applications of Nanomaterials as Sensing Platforms and Signal Amplification Markers at Electrochemical Immunosensors , 2016 .

[30]  Habib Tajalli,et al.  Highly sensitive electrochemiluminescence detection of p53 protein using functionalized Ru-silica nanoporous@gold nanocomposite. , 2016, Biosensors & bioelectronics.

[31]  Mohammad Hasanzadeh,et al.  Electrochemical biosensing using hydrogel nanoparticles , 2014 .

[32]  Dan Du,et al.  Graphene-based immunosensor for electrochemical quantification of phosphorylated p53 (S15). , 2011, Analytica chimica acta.

[33]  Adrian Krainer,et al.  p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state , 2014, Proceedings of the National Academy of Sciences.