Studies on the site of action of vasopressin in inducing adrenocorticotropin secretion.

Hypophysectomized rats bearing three transplanted pituitaries under the kidney capsule responded to synthetic lysine vasopressin or pitressin with a significant elevation of plasma corticosterone, whereas hypophysectomized rats with no grafts did not. This response was completely abolished by pretreatment of animals with dexamethasone but was unaltered by central hypothalamic destruction. Corticotropin-releasing factor content of the hypothalamic median eminence, hypophyseal stal-, or pars nervosa of the posterior pituitary of intact rats was unchanged 5 or 10 min after ip injection of vasopressin compared to the basal level. We conclude that vasopressin and dexamethasone act directly on the adenohypophysis in vivo to exert their stimulatory or inhibitory effect on ACTH secretion.

[1]  M. Greer,et al.  Distribution of corticotrophin releasing factor activity within the hypothalamic-pituitary complex of rats and cattle. , 1977, Journal of Endocrinology.

[2]  M. Brownstein,et al.  Corticotropin releasing factor distribution in normal and Brattleboro rat brain, and effect of deafferentation, hypophysectomy and steroid treatment in normal animals. , 1977, Endocrinology.

[3]  M. Greer,et al.  Distribution of corticotropin releasing factor(s) activity in neural and extraneural tissues of the rat. , 1976, Endocrinology.

[4]  M. Greer,et al.  Studies on the corticotrophin-releasing activity of vasopressin, using ACTH secretion by cultured rat adenohypophyseal cells. , 1976, Endocrinology.

[5]  M. Greer,et al.  Studies on ACTH dynamics in cultured adenohypophyseal cells: effect of adrenalectomy or dexamethasone in vitro. , 1976, Endocrinology.

[6]  M. Greer,et al.  Rat hypothalamic corticotropin-releasing factor (CRF) content remains constant despite marked acute or chronic changes in ACTH secretion. , 1976, Neuroendocrinology.

[7]  M. Greer,et al.  A sensitive and simple in vitro assay for corticotropin-releasing substances utilizing ACTH release from cultured anterior pituitary cells. , 1975, Endocrinology.

[8]  M. Greer,et al.  Evidence that the pars intermedia and pars nervosa of the pituitary do not secrete functionally significant quantities of ACTH. , 1975, Endocrinology.

[9]  M. Saffran,et al.  A semi-automated in vitro assay for CRF: activities of peptides related to oxytocin and vasopressin. , 1974, Neuroendocrinology.

[10]  G. Sayers,et al.  Isolated Pituitary Cells: CRF-Like Activity of Neurohypophysial and Related Polypeptides 1 , 1973, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[11]  V. Critchlow,et al.  Pituitary--adrenal function following ablation of medial basal hypothalamus. , 1973, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[12]  M. Palkovits,et al.  ACTH release in rats after removal of the medial hypothalamus. , 1973, Neuroendocrinology.

[13]  V. Critchlow,et al.  Vasopressin-Evoked ACTH Release in Rats Following Forebrain Removal 1 , 1971, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[14]  F. Yates,et al.  Potentiation by vasopressin of corticotropin release induced by corticotropin-releasing factor. , 1971, Endocrinology.

[15]  A. Schally,et al.  Effect of corticotropin-releasing factor, dexamethasone and actinomycin D on the release of ACTH from rat pituitaries in vivo and in vitro. , 1969, Endocrinology.

[16]  D. de Wied,et al.  Comparison of assays for corticotrophin-releasing activity. , 1969, Endocrinology.

[17]  J. Dingman,et al.  The effect of lysine vasopressin and hypothalamic extracts on the rate of corticosterone secretion in rats treated with dexamethasone and pentobarbitone. , 1969, The Journal of endocrinology.

[18]  V. Critchlow,et al.  Feedback suppression of 'non-stress' pituitary-adrenal function in rats with forebrain removed. , 1969, Neuroendocrinology.

[19]  W. Vale,et al.  Inhibition of vasopressin-induced ACTH release from the pituitary by glucocorticoids in vitro. , 1968, Endocrinology.

[20]  H. Kunita,et al.  Effects on ACTH release, of intrapituitary injections of posterior pituitary hormones and several amines in the hypothalamus. , 1968, The Japanese journal of physiology.

[21]  F. Yates,et al.  Site of action of vasopressin in causing corticotropin release. , 1966, Endocrinology.

[22]  J. Landon,et al.  Assessment of hypothalamic pituitary function in endocrine disease , 1966, Journal of clinical pathology.

[23]  M. Greer,et al.  Evidence for ACTH secretion and ACTH suppressibility in hypophysectomized rats with multiple heterotopic pituitaries. , 1966, Endocrinology.

[24]  M. Motta,et al.  CHAPTER 9 – Control of Adrenocorticotropic Hormone Secretion , 1966 .

[25]  G. Gwinup.  Studies on the mechanism of vasopressin-induced steroid secretion in man. , 1965, Metabolism: clinical and experimental.

[26]  L. Librik,et al.  Effect of corticosteroid administration on vasopressin-induced adrenocorticotropin release in man. , 1965, The Journal of clinical endocrinology and metabolism.

[27]  D. Wied.  An assay of corticotrophin-releasing principles in hypothalamic lesioned rats. , 1961 .

[28]  J. Brobeck,et al.  Evidence for a Role of the Supraopticohypophyseal System in Regulation of Adrenocorticotropic Secretion , 1954, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.