论文信息 - Identification and initial structure-activity relationships of a novel non-peptide quinolone GnRH receptor antagonist. - 字舞流文

Identification and initial structure-activity relationships of a novel non-peptide quinolone GnRH receptor antagonist.

R G Smith | R. DeVita | M. Fisher | M. Wyvratt | Y. Yang | M. Goulet | R. Smith | J L Lo | Y T Yang | K Cheng | M H Fisher | M J Wyvratt | M T Goulet | R J DeVita | D D Hollings | K. Cheng | J. Lo | D. Hollings

[1] R. DeVita,et al. Investigation of the 4-O-alkylamine substituent of non-peptide quinolone GnRH receptor antagonists. , 1999, Bioorganic & medicinal chemistry letters.

[2] S. Sasaki,et al. Discovery of a novel, potent, and orally active nonpeptide antagonist of the human luteinizing hormone-releasing hormone (LHRH) receptor. , 1998, Journal of medicinal chemistry.

[3] J. Engel,et al. Chemistry and Molecular Biology in the Search for New LHRH Antagonists , 1997 .

[4] J. Kemp,et al. 4-substituted-3-phenylquinolin-2(1H)-ones: acidic and nonacidic glycine site N-methyl-D-aspartate antagonists with in vivo activity. , 1997, Journal of medicinal chemistry.

[5] R. Barbieri. Clinical applications of GnRH and its analogues , 1992, Trends in Endocrinology & Metabolism.

[6] A. Heitz,et al. A facile synthesis of chiral N-protected β-amino alcohols. , 1991 .

[7] W. Crowley,et al. Gonadotropin-releasing hormone and its analogues. , 1991, The New England journal of medicine.

[8] H. Rapoport,et al. .alpha.-Methylenelactam rearrangement , 1974 .

[9] A. Schally,et al. Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence. , 1971, Biochemical and biophysical research communications.

[10] J. Faust,et al. 2-, 3- and 4-(1-Methylpiperidyl)-carbinols and Derivatives , 1952 .

[11] R. C. Fuson,et al. Ring Enlargement by Rearrangement of the 1,2-Aminochloroalkyl Group; Rearrangement of 1-Ethyl-2-chloromethylpyrrolidine to 1-Ethyl-3-chloropiperidine , 1948 .

[12] R. S. Harris,et al. Vitamins and Hormones , 1948 .