Greater activation of peripheral T follicular helper cells following high dose influenza vaccine in older adults forecasts seroconversion.

[1]  L. Haynes,et al.  Age-related impairment of humoral response to influenza is associated with changes in antigen specific T follicular helper cell responses , 2016, Scientific Reports.

[2]  Mark M. Davis,et al.  CXCL13 is a plasma biomarker of germinal center activity , 2016, Proceedings of the National Academy of Sciences.

[3]  Jerome H. Kim,et al.  Circulating HIV-Specific Interleukin-21(+)CD4(+) T Cells Represent Peripheral Tfh Cells with Antigen-Dependent Helper Functions. , 2016, Immunity.

[4]  C. Robertson,et al.  Prevention of serious events in adults 65 years of age or older: A comparison between high-dose and standard-dose inactivated influenza vaccines. , 2015, Vaccine.

[5]  C. Ottensmeier,et al.  Vaccination Expands Antigen-Specific CD4+ Memory T Cells and Mobilizes Bystander Central Memory T Cells , 2015, PloS one.

[6]  Michael Poidinger,et al.  Mapping the Diversity of Follicular Helper T Cells in Human Blood and Tonsils Using High-Dimensional Mass Cytometry Analysis. , 2015, Cell reports.

[7]  M. Fischl,et al.  HIV infection Worsens Age-Associated Defects in Antibody Responses to Influenza Vaccine. , 2015, The Journal of infectious diseases.

[8]  Thomas MaCurdy,et al.  Comparative effectiveness of high-dose versus standard-dose influenza vaccines in US residents aged 65 years and older from 2012 to 2013 using Medicare data: a retrospective cohort analysis. , 2015, The Lancet. Infectious diseases.

[9]  D. Dolfi,et al.  Circulating CXCR5+PD-1+ Response Predicts Influenza Vaccine Antibody Responses in Young Adults but not Elderly Adults , 2014, The Journal of Immunology.

[10]  John Earl,et al.  Efficacy of high-dose versus standard-dose influenza vaccine in older adults. , 2014, The New England journal of medicine.

[11]  Jerome H. Kim,et al.  Loss of Circulating CD4 T Cells with B Cell Helper Function during Chronic HIV Infection , 2014, PLoS pathogens.

[12]  M. Linterman How T follicular helper cells and the germinal centre response change with age , 2014, Immunology and cell biology.

[13]  C. Mackay,et al.  Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure. , 2013, Immunity.

[14]  Alessandro Sette,et al.  Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses. , 2013, Immunity.

[15]  Sean C. Bendall,et al.  viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia , 2013, Nature Biotechnology.

[16]  Jonathan L. Linehan,et al.  Single Naive CD4+ T Cells from a Diverse Repertoire Produce Different Effector Cell Types during Infection , 2013, Cell.

[17]  F. Sallusto,et al.  Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype. , 2013, Immunity.

[18]  Virginia Pascual,et al.  Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza Vaccination , 2013, Science Translational Medicine.

[19]  C. Diazgranados,et al.  High-dose trivalent influenza vaccine compared to standard dose vaccine in elderly adults: safety, immunogenicity and relative efficacy during the 2009-2010 season. , 2013, Vaccine.

[20]  M. Fischl,et al.  Impaired peripheral blood T-follicular helper cell function in HIV-infected nonresponders to the 2009 H1N1/09 vaccine. , 2012, Blood.

[21]  T. Mosmann,et al.  Ki-67 expression reveals strong, transient influenza specific CD4 T cell responses after adult vaccination. , 2012, Vaccine.

[22]  K. Fink Origin and Function of Circulating Plasmablasts during Acute Viral Infections , 2012, Front. Immun..

[23]  Mark M. Davis,et al.  Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies. , 2011, The Journal of clinical investigation.

[24]  C. Mackay,et al.  CXCR5 Expressing Human Central Memory CD4 T Cells and Their Relevance for Humoral Immune Responses , 2011, The Journal of Immunology.

[25]  W. Blackwelder,et al.  Antibody and Th1-type cell-mediated immune responses in elderly and young adults immunized with the standard or a high dose influenza vaccine. , 2011, Vaccine.

[26]  S. Crotty,et al.  Follicular helper CD4 T cells (TFH). , 2011, Annual review of immunology.

[27]  H. Ueno,et al.  Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. , 2011, Immunity.

[28]  Nikesh Kotecha,et al.  Web‐Based Analysis and Publication of Flow Cytometry Experiments , 2010, Current protocols in cytometry.

[29]  S. Varga,et al.  Effects of aging on the adaptive immune response to respiratory virus infections. , 2009, Aging health.

[30]  R. Channappanavar,et al.  Advancing age leads to predominance of inhibitory receptor expressing CD4 T cells , 2009, Mechanisms of Ageing and Development.

[31]  N. Cox,et al.  Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2009. , 2009, MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports.

[32]  A. Falsey,et al.  Randomized, double-blind controlled phase 3 trial comparing the immunogenicity of high-dose and standard-dose influenza vaccine in adults 65 years of age and older. , 2009, The Journal of infectious diseases.

[33]  N. Weng,et al.  CD28(-) T cells: their role in the age-associated decline of immune function. , 2009, Trends in immunology.

[34]  R. Couch,et al.  Safety and immunogenicity of a high dosage trivalent influenza vaccine among elderly subjects. , 2007, Vaccine.

[35]  D. Mehta,et al.  Diversity of the Ig Repertoire is Maintained With Age In Spite of Reduced Germinal Centre Cells in Human Tonsil Lymphoid Tissue , 2006, Scandinavian journal of immunology.

[36]  H. Rahn,et al.  Follicular B helper T cell activity is confined to CXCR5hiICOShi CD4 T cells and is independent of CD57 expression , 2006, European journal of immunology.

[37]  R. Couch,et al.  Safety of high doses of influenza vaccine and effect on antibody responses in elderly persons. , 2006, Archives of internal medicine.

[38]  R. Steinman,et al.  Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses , 2006, The Journal of experimental medicine.

[39]  Cécile Viboud,et al.  Antibody response to influenza vaccination in the elderly: a quantitative review. , 2006, Vaccine.

[40]  Kim L Kusser,et al.  Age-related Defects in CD4 T Cell Cognate Helper Function Lead to Reductions in Humoral Responses , 2004, The Journal of experimental medicine.

[41]  Alvin S. Teirstein,et al.  DIAGNOSIS OF LEGIONELLA INFECTION , 2002 .

[42]  E. Kremmer,et al.  Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production , 2000, The Journal of experimental medicine.

[43]  L. Lum,et al.  Specific humoral immunity in the elderly: in vivo and in vitro response to vaccination. , 1993, Journal of gerontology.