The SARS Coronavirus E Protein Interacts with PALS1 and Alters Tight Junction Formation and Epithelial Morphogenesis

The E protein of the Severe Acute Respiratory Syndrome Coronavirus binds the tight junction protein PALS1 through a novel PDZ domain-binding motif/PDZ domain interaction. Expression of E delays formation of tight junctions and alters cyst morphogenesis of MDCKII epithelial cells.

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