Efficient delivery of sticky siRNA and potent gene silencing in a prostate cancer model using a generation 5 triethanolamine-core PAMAM dendrimer.
暂无分享,去创建一个
Sabrina Pricl | Paola Posocco | Erik Laurini | Cheng Liu | Ling Peng | Fanqi Qu | C. Liu | E. Laurini | S. Pricl | P. Posocco | Ling Peng | Xiaoxuan Liu | P. Rocchi | Fanqi Qu | Xiaoxuan Liu | Palma Rocchi | Cheng Liu
[1] Jean-Paul Behr,et al. Sticky overhangs enhance siRNA-mediated gene silencing , 2007, Proceedings of the National Academy of Sciences.
[2] Sabrina Pricl,et al. Less is more – multiscale modelling of self-assembling multivalency and its impact on DNA binding and gene delivery , 2010 .
[3] C. Pichon,et al. Polymer-based gene delivery: a current review on the uptake and intracellular trafficking of polyplexes. , 2008, Current gene therapy.
[4] Robert Langer,et al. Knocking down barriers: advances in siRNA delivery , 2009, Nature Reviews Drug Discovery.
[5] Ling Peng,et al. PAMAM dendrimers for efficient siRNA delivery and potent gene silencing. , 2006, Chemical communications.
[6] S. Kannan,et al. The effect of surface functionality on cellular trafficking of dendrimers. , 2008, Biomaterials.
[7] S. Pricl,et al. PAMAM dendrimers for siRNA delivery: computational and experimental insights. , 2010, Chemistry.
[8] M. Gleave,et al. Heat Shock Protein 27 Increases after Androgen Ablation and Plays a Cytoprotective Role in Hormone-Refractory Prostate Cancer , 2004, Cancer Research.
[9] P. Kollman,et al. Continuum Solvent Studies of the Stability of DNA, RNA, and Phosphoramidate−DNA Helices , 1998 .
[10] U. Huth,et al. Investigating the uptake and intracellular fate of pH-sensitive liposomes by flow cytometry and spectral bio-imaging. , 2006, Journal of controlled release : official journal of the Controlled Release Society.
[11] Beverly L. Davidson,et al. Current prospects for RNA interference-based therapies , 2011, Nature Reviews Genetics.
[12] M. Gleave,et al. Increased Hsp27 after androgen ablation facilitates androgen-independent progression in prostate cancer via signal transducers and activators of transcription 3-mediated suppression of apoptosis. , 2005, Cancer research.
[13] Ling Peng,et al. Systemic administration of combinatorial dsiRNAs via nanoparticles efficiently suppresses HIV-1 infection in humanized mice. , 2011, Molecular therapy : the journal of the American Society of Gene Therapy.
[14] F Philipp Seib,et al. Comparison of the endocytic properties of linear and branched PEIs, and cationic PAMAM dendrimers in B16f10 melanoma cells. , 2007, Journal of controlled release : official journal of the Controlled Release Society.
[15] J. Neoptolemos,et al. Heat shock protein expression independently predicts clinical outcome in prostate cancer. , 2000, Cancer research.
[16] M. Gleave,et al. Small interference RNA targeting heat‐shock protein 27 inhibits the growth of prostatic cell lines and induces apoptosis via caspase‐3 activation in vitro , 2006, BJU international.
[17] A. D'emanuele,et al. Surface modification of PAMAM dendrimers modulates the mechanism of cellular internalization. , 2009, Bioconjugate chemistry.
[18] Maurizio Fermeglia,et al. Structurally flexible triethanolamine core PAMAM dendrimers are effective nanovectors for DNA transfection in vitro and in vivo to the mouse thymus. , 2011, Bioconjugate chemistry.
[19] E. Karapanagiotou,et al. Targeted therapeutic approaches for hormone-refractory prostate cancer. , 2010, Cancer treatment reviews.
[20] D. Scherman,et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[21] Judy Lieberman,et al. Interfering with disease: a progress report on siRNA-based therapeutics , 2007, Nature Reviews Drug Discovery.
[22] John J. Rossi,et al. The promises and pitfalls of RNA-interference-based therapeutics , 2009, Nature.
[23] Ling Peng,et al. PAMAM Dendrimers Mediate siRNA Delivery to Target Hsp27 and Produce Potent Antiproliferative Effects on Prostate Cancer Cells , 2009, ChemMedChem.
[24] A. George,et al. Gene delivery by dendrimers operates via different pathways in different cells, but is enhanced by the presence of caveolin. , 2006, Journal of immunological methods.
[25] Cheng-Cai Zhang,et al. Importance of size-to-charge ratio in construction of stable and uniform nanoscale RNA/dendrimer complexes. , 2007, Organic & biomolecular chemistry.
[26] A. Jemal,et al. Cancer Statistics, 2010 , 2010, CA: a cancer journal for clinicians.
[27] A. Bolcato-Bellemin,et al. Systemic Delivery of DNA or siRNA Mediated by Linear Polyethylenimine (L-PEI) Does Not Induce an Inflammatory Response , 2008, Pharmaceutical Research.
[28] Ling Peng,et al. Polycationic dendrimers interact with RNA molecules: polyamine dendrimers inhibit the catalytic activity of Candida ribozymes. , 2005, Chemical communications.