Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy

Optimizing contrast enhancement is essential for producing specific signals in biomedical imaging and therapy. The potential of using Aucore-Agshell nanorods (Au@Ag NRs) as a dual-functional theranostic contrast agent is demonstrated for effective cancer imaging and treatments. Due to its strong NIR absorption and high efficiency of photothermal conversion, effects of both photoacoustic tomography (PAT) and photothermal therapy (PTT) are enhanced significantly. The PAT signal grows by 45.3% and 82% in the phantom and in vivo experiments, respectively, when compared to those using Au NRs. In PTT, The maximum increase of tissue temperature treated with Au@Ag NRs is 22.8 °C, twice that with Au NRs. Results of the current study show the feasibility of using Au@Ag NRs for synergetic PAT with PTT. And it will enhance the potential application on real-time PAT guided PTT, which will greatly benefit the customized PTT treatment of cancer.

[1]  S. Loefas,et al.  Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors. , 1991, Analytical biochemistry.

[2]  Erkki Ruoslahti,et al.  Phage Libraries Displaying Cyclic Peptides with Different Ring Sizes: Ligand Specificities of the RGD-Directed Integrins , 1995, Bio/Technology.

[3]  Chil Seong Ah,et al.  Preparation of AucoreAgshell Nanorods and Characterization of Their Surface Plasmon Resonances , 2001 .

[4]  Catherine J. Murphy,et al.  CONTROLLING THE ASPECT RATIO OF INORGANIC NANORODS AND NANOWIRES , 2002 .

[5]  Philippe Guyot-Sionnest,et al.  Synthesis and Optical Characterization of Au/Ag Core/Shell Nanorods , 2004 .

[6]  H. Ghandehari,et al.  Targeting tumor angiogenic vasculature using polymer-RGD conjugates. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[7]  Feng Gao,et al.  End-to-end self-assembly and colorimetric characterization of gold nanorods and nanospheres via oligonucleotide hybridization , 2005 .

[8]  Dakrong Pissuwan,et al.  A golden bullet? Selective targeting of Toxoplasma gondii tachyzoites using antibody-functionalized gold nanorods. , 2007, Nano letters.

[9]  Ji-Xin Cheng,et al.  Hyperthermic effects of gold nanorods on tumor cells. , 2007, Nanomedicine.

[10]  Weihong Tan,et al.  Selective photothermal therapy for mixed cancer cells using aptamer-conjugated nanorods. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[11]  Alexander A. Oraevsky,et al.  30 Gold and Silver Nanoparticles as Contrast Agents for Optoacoustic Tomography , 2009 .

[12]  Lihong V. Wang,et al.  In-vivo photoacoustic microscopy of nanoshell extravasation from solid tumor vasculature. , 2009, Journal of biomedical optics.

[13]  Manojit Pramanik,et al.  Near infrared photoacoustic detection of sentinel lymph nodes with gold nanobeacons. , 2010, Biomaterials.

[14]  Stanislav Emelianov,et al.  Silver nanosystems for photoacoustic imaging and image-guided therapy. , 2010, Journal of biomedical optics.

[15]  Feng Gao,et al.  RGD-conjugated dendrimer-modified gold nanorods for in vivo tumor targeting and photothermal therapy. , 2010, Molecular pharmaceutics.

[16]  R. Hurt,et al.  Controlled release of biologically active silver from nanosilver surfaces. , 2010, ACS nano.

[17]  Matthias Epple,et al.  TOXICITY OF SILVER NANOPARTICLES INCREASES DURING STORAGE BECAUSE OF SLOW DISSOLUTION UNDER RELEASE OF SILVER IONS , 2010 .

[18]  Christopher G. Rylander,et al.  Photothermal response of human and murine cancer cells to multiwalled carbon nanotubes after laser irradiation. , 2010, Cancer research.

[19]  D. Pozo,et al.  Silver Nanoparticles: Sensing and Imaging Applications , 2010 .

[20]  Feng Gao,et al.  In vivo molecular photoacoustic tomography of melanomas targeted by bioconjugated gold nanocages. , 2010, ACS nano.

[21]  Wei Lu,et al.  Effects of photoacoustic imaging and photothermal ablation therapy mediated by targeted hollow gold nanospheres in an orthotopic mouse xenograft model of glioma. , 2011, Cancer research.

[22]  Stanislav Y. Emelianov,et al.  Biomedical Applications of Photoacoustic Imaging with Exogenous Contrast Agents , 2011, Annals of Biomedical Engineering.

[23]  M. Potara,et al.  Chitosan-coated triangular silver nanoparticles as a novel class of biocompatible, highly effective photothermal transducers for in vitro cancer cell therapy. , 2011, Cancer letters.

[24]  Stanislav Emelianov,et al.  Multiplex photoacoustic molecular imaging using targeted silica-coated gold nanorods , 2011, Biomedical optics express.

[25]  S. Emelianov,et al.  Silica-coated gold nanorods as photoacoustic signal nanoamplifiers. , 2011, Nano letters.

[26]  Lihong V. Wang,et al.  Quantitative photoacoustic imaging: correcting for heterogeneous light fluence distributions using diffuse optical tomography. , 2011, Journal of biomedical optics.

[27]  F. M. van den Engh,et al.  Visualizing breast cancer using the Twente photoacoustic mammoscope: what do we learn from twelve new patient measurements? , 2012, Optics express.

[28]  Doyeon Bang,et al.  Targetable gold nanorods for epithelial cancer therapy guided by near-IR absorption imaging. , 2012, Small.

[29]  Stanislav Emelianov,et al.  Silver nanoplate contrast agents for in vivo molecular photoacoustic imaging. , 2012, ACS nano.

[30]  Da Xing,et al.  Intracellular label-free gold nanorods imaging with photoacoustic microscopy. , 2012, Optics express.

[31]  Pedro J J Alvarez,et al.  Negligible particle-specific antibacterial activity of silver nanoparticles. , 2012, Nano letters.

[32]  Hai Ming,et al.  Effect of shell thickness on a Au–Ag core–shell nanorods-based plasmonic nano-sensor , 2012 .

[33]  R. Hurt,et al.  Chemical transformations of nanosilver in biological environments. , 2012, ACS nano.

[34]  Zahi A Fayad,et al.  Multifunctional gold nanoparticles for diagnosis and therapy of disease. , 2013, Molecular pharmaceutics.

[35]  Zhe Wang,et al.  Biodegradable gold nanovesicles with an ultrastrong plasmonic coupling effect for photoacoustic imaging and photothermal therapy. , 2013, Angewandte Chemie.

[36]  Daxiang Cui,et al.  Picomolar detection of mercuric ions by means of gold-silver core-shell nanorods. , 2013, Nanoscale.

[37]  C. Ahn,et al.  Biocompatible Glycol Chitosan-Coated Gold Nanoparticles for Tumor-Targeting CT Imaging , 2013, Pharmaceutical Research.

[38]  M. El-Sayed,et al.  Different Plasmon Sensing Behavior of Silver and Gold Nanorods. , 2013, The journal of physical chemistry letters.

[39]  P. Debata,et al.  Multifunctional PEG encapsulated Fe3O4@silver hybrid nanoparticles: antibacterial activity, cell imaging and combined photothermo/chemo-therapy. , 2013, Journal of materials chemistry. B.

[40]  Chris Jun Hui Ho,et al.  Multifunctional Photosensitizer-Based Contrast Agents for Photoacoustic Imaging , 2014, Scientific Reports.

[41]  Mukund Seshadri,et al.  Non-invasive, Multimodal Functional Imaging of the Intestine with Frozen Micellar Naphthalocyanines , 2014, Nature nanotechnology.

[42]  Vasilis Ntziachristos,et al.  Estimation of optoacoustic contrast agent concentration with self-calibration blind logarithmic unmixing. , 2014, Physics in medicine and biology.

[43]  Jesse V. Jokerst,et al.  Construction and Validation of Nano Gold Tripods for Molecular Imaging of Living Subjects , 2014, Journal of the American Chemical Society.

[44]  R. Kopelman,et al.  Multifunctional theranostic gold nanoparticles for targeted CT imaging and photothermal therapy. , 2014, Contrast media & molecular imaging.

[45]  S. Emelianov,et al.  In-vivo ultrasound and photoacoustic image- guided photothermal cancer therapy using silica-coated gold nanorods , 2014, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control.

[46]  N. Thakor,et al.  Rare-Earth Doped Particles as Dual-Modality Contrast Agent for Minimally-Invasive Luminescence and Dual-Wavelength Photoacoustic Imaging , 2014, Scientific Reports.

[47]  Q. Ren,et al.  PEGylated Aucore–Agshell Nanorods as Optical Coherence Tomography Signal Nanoamplifiers , 2015, Plasmonics.