Dopamine‐Related Genotypes and Physical Activity Change During an Intervention: The Lifestyle Interventions and Independence for Elders Study

To determine whether intervention‐induced physical activity (PA) changes in sedentary older adults differed according to dopamine‐related genotype.

[1]  S. Studenski,et al.  Longitudinal Associations Between Walking Speed and Amount of Self-reported Time Spent Walking Over a 9-Year Period in Older Women and Men , 2018, The journals of gerontology. Series A, Biological sciences and medical sciences.

[2]  L. Ferrucci,et al.  A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. , 1994, Journal of gerontology.

[3]  Charles E Matthew,et al.  Calibration of accelerometer output for adults. , 2005, Medicine and science in sports and exercise.

[4]  Quanzheng Li,et al.  Treadmill exercise elevates striatal dopamine D2 receptor binding potential in patients with early Parkinson’s disease , 2013, Neuroreport.

[5]  J. Savitz,et al.  The molecular genetics of cognition: dopamine, COMT and BDNF , 2006, Genes, brain, and behavior.

[6]  J. Jankovic,et al.  A functional variant of the dopamine D3 receptor is associated with risk and age-at-onset of essential tremor. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[7]  A. King,et al.  Dose of physical activity, physical functioning and disability risk in mobility-limited older adults: Results from the LIFE study randomized trial , 2017, PloS one.

[8]  B. Kolachana,et al.  Variation in dopamine genes influences responsivity of the human reward system , 2009, Proceedings of the National Academy of Sciences.

[9]  C. Bouchard,et al.  A dopamine D2 receptor gene polymorphism and physical activity in two family studies , 2003, Physiology & Behavior.

[10]  D. Vancampfort,et al.  Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias , 2016, Revista brasileira de psiquiatria.

[11]  X. Zhuang,et al.  Low Dopamine D2 Receptor Increases Vulnerability to Obesity Via Reduced Physical Activity, Not Increased Appetitive Motivation , 2016, Biological Psychiatry.

[12]  Michael E. Miller,et al.  Reliability of the 400‐M Usual‐Pace Walk Test as an Assessment of Mobility Limitation in Older Adults , 2004, Journal of the American Geriatrics Society.

[13]  Michael E. Miller,et al.  The Lifestyle Interventions and Independence for Elders Study: Design and Methods , 2011, The journals of gerontology. Series A, Biological sciences and medical sciences.

[14]  H. Chui,et al.  The Modified Mini-Mental State (3MS) examination. , 1987, The Journal of clinical psychiatry.

[15]  R B Wallace,et al.  Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. , 1995, The New England journal of medicine.

[16]  O. Darbin The aging striatal dopamine function. , 2012, Parkinsonism & related disorders.

[17]  M. Mędraś,et al.  DRD2 C313T and DRD4 48-bp VNTR polymorphisms and physical activity of healthy men in Lower Silesia, Poland (HALS study) , 2013, Annals of human biology.

[18]  Leena Choi,et al.  Validation of accelerometer wear and nonwear time classification algorithm. , 2011, Medicine and science in sports and exercise.

[19]  J. Guralnik,et al.  Lifestyle interventions and independence for elders study: recruitment and baseline characteristics. , 2013, The journals of gerontology. Series A, Biological sciences and medical sciences.

[20]  P. Gareri,et al.  Neuropharmacology of depression in aging and age-related diseases , 2002, Ageing Research Reviews.

[21]  Catherine Sherrington,et al.  Adherence to exercise programs for older people is influenced by program characteristics and personal factors: a systematic review. , 2014, Journal of physiotherapy.

[22]  Lauren E. Oberlin,et al.  Role of Brain Structure in Predicting Adherence to a Physical Activity Regimen , 2017, Psychosomatic medicine.

[23]  B. Cardinal,et al.  Theory-based physical activity beliefs by race and activity levels among older adults , 2016, Ethnicity & health.

[24]  J. Becker Gender Differences in Dopaminergic Function in Striatum and Nucleus Accumbens , 1999, Pharmacology Biochemistry and Behavior.

[25]  Yong-sheng Zhu,et al.  An association study between dopamine D1 receptor gene polymorphisms and the risk of schizophrenia , 2011, Brain Research.

[26]  M. Herring,et al.  Genetic factors in exercise adoption, adherence and obesity , 2014, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[27]  Liana Machado,et al.  Benefits of regular aerobic exercise for executive functioning in healthy populations , 2013, Psychonomic bulletin & review.

[28]  L. Radloff The CES-D Scale , 1977 .

[29]  J. Williamson,et al.  Effect of a 24-Month Physical Activity Intervention vs Health Education on Cognitive Outcomes in Sedentary Older Adults: The LIFE Randomized Trial. , 2015, JAMA.

[30]  J. Tucker,et al.  Physical activity in U.S.: adults compliance with the Physical Activity Guidelines for Americans. , 2011, American journal of preventive medicine.

[31]  Michael E. Miller,et al.  Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial. , 2014, JAMA.

[32]  Roshan Cools,et al.  Role of Dopamine in the Motivational and Cognitive Control of Behavior , 2008, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[33]  Leonardo Fazio,et al.  D2 receptor genotype and striatal dopamine signaling predict motor cortical activity and behavior in humans , 2011, NeuroImage.

[34]  M. Hamer,et al.  Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence , 2008, Psychological Medicine.

[35]  J. Best,et al.  Larger Lateral Prefrontal Cortex Volume Predicts Better Exercise Adherence Among Older Women: Evidence From Two Exercise Training Studies , 2017, The journals of gerontology. Series A, Biological sciences and medical sciences.

[36]  A. Veronica Witte,et al.  Effects of COMT polymorphisms on brain function and behavior in health and disease , 2012, Brain Research Bulletin.

[37]  A. Grace,et al.  The Catechol-O-Methyltransferase Polymorphism: Relations to the Tonic–Phasic Dopamine Hypothesis and Neuropsychiatric Phenotypes , 2004, Neuropsychopharmacology.

[38]  J S Fowler,et al.  PET studies of the effects of aerobic exercise on human striatal dopamine release. , 2000, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[39]  Edythe D London,et al.  Effect of Exercise Training on Striatal Dopamine D2/D3 Receptors in Methamphetamine Users during Behavioral Treatment , 2016, Neuropsychopharmacology.

[40]  P. Sullivan,et al.  Genome-wide association study of exercise behavior in Dutch and American adults. , 2009, Medicine and science in sports and exercise.

[41]  Ack,et al.  LOWER-EXTREMITY FUNCTION IN PERSONS OVER THE AGE OF 70 YEARS AS A PREDICTOR OF SUBSEQUENT DISABILITY , 2001 .

[42]  P. Scheet,et al.  The Dopaminergic Reward System and Leisure Time Exercise Behavior: A Candidate Allele Study , 2014, BioMed research international.