Leukemogenesis Induced by an Activating β-catenin mutation in Osteoblasts

[1]  Raul Rabadan,et al.  SAVI: a statistical algorithm for variant frequency identification , 2013, BMC Systems Biology.

[2]  E. Hsiao,et al.  Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche. , 2013, Cell stem cell.

[3]  Benjamin J. Raphael,et al.  Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. , 2013, The New England journal of medicine.

[4]  J. McMurray,et al.  Notch activation inhibits AML growth and survival: a potential therapeutic approach , 2013, The Journal of experimental medicine.

[5]  S. Armstrong,et al.  Notch pathway activation targets AML-initiating cell homeostasis and differentiation , 2013, The Journal of experimental medicine.

[6]  A. Raza,et al.  The genetic basis of phenotypic heterogeneity in myelodysplastic syndromes , 2012, Nature Reviews Cancer.

[7]  S. Cremers,et al.  Circulating osteogenic precursor cells in type 2 diabetes mellitus. , 2012, The Journal of clinical endocrinology and metabolism.

[8]  R R Recker,et al.  Issues in modern bone histomorphometry. , 2011, Bone.

[9]  Iannis Aifantis,et al.  Oncogenic and tumor suppressor functions of Notch in cancer: it’s NOTCH what you think , 2011, The Journal of experimental medicine.

[10]  S. Pileri,et al.  BRAF mutations in hairy-cell leukemia. , 2011, The New England journal of medicine.

[11]  S. Cremers,et al.  Parathyroid hormone stimulates circulating osteogenic cells in hypoparathyroidism. , 2011, The Journal of clinical endocrinology and metabolism.

[12]  K. Pienta,et al.  Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow. , 2011, The Journal of clinical investigation.

[13]  O. Abdel-Wahab,et al.  A novel tumor suppressor function for the Notch pathway in myeloid leukemia , 2011, Nature.

[14]  Charles P. Lin,et al.  Bone progenitor dysfunction induces myelodysplasia and secondary leukemia , 2010, Nature.

[15]  R. DePinho,et al.  FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts. , 2010, Cell metabolism.

[16]  Colleen Delaney,et al.  Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution , 2010, Nature Medicine.

[17]  Richard Durbin,et al.  Fast and accurate long-read alignment with Burrows–Wheeler transform , 2010, Bioinform..

[18]  R. DePinho,et al.  FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice. , 2010, The Journal of clinical investigation.

[19]  Richard Durbin,et al.  Sequence analysis Fast and accurate short read alignment with Burrows – Wheeler transform , 2009 .

[20]  Sandra A. Moore,et al.  The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model. , 2009, The Journal of clinical investigation.

[21]  A. McMahon,et al.  Osteoblastic regulation of B lymphopoiesis is mediated by Gsα-dependent signaling pathways , 2008, Proceedings of the National Academy of Sciences.

[22]  I. Weissman,et al.  Endochondral ossification is required for hematopoietic stem cell niche formation , 2008, Nature.

[23]  A. Wagers,et al.  Osteolineage niche cells initiate hematopoietic stem cell mobilization. , 2008, Blood.

[24]  M. McDermott,et al.  Notch activation is associated with tetraploidy and enhanced chromosomal instability in meningiomas. , 2008, Neoplasia.

[25]  V. V. D. van der Velden,et al.  Identification of distinct prognostic subgroups in low- and intermediate-1-risk myelodysplastic syndromes by flow cytometry. , 2008, Blood.

[26]  P. Chambon,et al.  A Microenvironment-Induced Myeloproliferative Syndrome Caused by Retinoic Acid Receptor γ Deficiency , 2007, Cell.

[27]  Younghun Jung,et al.  Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells. , 2007, Blood.

[28]  Fiona M Watt,et al.  Jagged 1 is a β-catenin target gene required for ectopic hair follicle formation in adult epidermis , 2006 .

[29]  A. Look,et al.  Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia , 2006, Nature Reviews Cancer.

[30]  A. Kiernan,et al.  The Notch Ligand JAG1 Is Required for Sensory Progenitor Development in the Mammalian Inner Ear , 2006, PLoS genetics.

[31]  P. Vyas,et al.  Evidence for reduced B-cell progenitors in early (low-risk) myelodysplastic syndrome. , 2005, Blood.

[32]  Hans Clevers,et al.  Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells , 2005, Nature.

[33]  B. Riggs,et al.  Circulating osteoblast-lineage cells in humans. , 2005, The New England journal of medicine.

[34]  Hans Clevers,et al.  Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. , 2005, Developmental cell.

[35]  U. Suter,et al.  Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation. , 2005, Blood.

[36]  Dennis B. Troup,et al.  NCBI GEO: mining millions of expression profiles—database and tools , 2004, Nucleic Acids Res..

[37]  R. Nusse,et al.  The Wnt signaling pathway in development and disease. , 2004, Annual review of cell and developmental biology.

[38]  C. Tomlinson,et al.  Design and Analysis of DNA Microarray Investigations , 2004 .

[39]  Gordon K Smyth,et al.  Statistical Applications in Genetics and Molecular Biology Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments , 2011 .

[40]  D. Scadden,et al.  Osteoblastic cells regulate the haematopoietic stem cell niche , 2003, Nature.

[41]  Haiyang Huang,et al.  Identification of the haematopoietic stem cell niche and control of the niche size , 2003, Nature.

[42]  S. Ogawa,et al.  Notch1 but not Notch2 is essential for generating hematopoietic stem cells from endothelial cells. , 2003, Immunity.

[43]  Wei-Min Liu,et al.  Robust estimators for expression analysis , 2002, Bioinform..

[44]  J. Downing,et al.  Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. , 2002, Blood.

[45]  G. Karsenty,et al.  Mouse α1(I)‐collagen promoter is the best known promoter to drive efficient Cre recombinase expression in osteoblast , 2002, Developmental dynamics : an official publication of the American Association of Anatomists.

[46]  S. Rafii,et al.  Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-Ligand , 2002, Cell.

[47]  J. Sundberg,et al.  Notch signaling is essential for vascular morphogenesis in mice. , 2000, Genes & development.

[48]  M. Taketo,et al.  Intestinal polyposis in mice with a dominant stable mutation of the β‐catenin gene , 1999, The EMBO journal.

[49]  J. Rossert,et al.  Separate cis-acting DNA elements of the mouse pro-alpha 1(I) collagen promoter direct expression of reporter genes to different type I collagen-producing cells in transgenic mice , 1995, The Journal of cell biology.

[50]  M. Drezner,et al.  Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee , 1987, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[51]  Iannis Aifantis,et al.  γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia , 2009, Nature Medicine.

[52]  G. Mundy,et al.  Expression of the BMP 2 gene during bone cell differentiation. , 1994, Critical reviews in eukaryotic gene expression.

[53]  R. Recker,et al.  Bone histomorphometry : techniques and interpretation , 1983 .