Dopamine transporter and D2 receptor binding densities in mice prone or resistant to chronic high fat diet-induced obesity

This study examined the density of dopamine transporter (DAT) and D2 receptors in the brains of chronic high-fat diet-induced obese (cDIO), obese-resistant (cDR) and low-fat-fed (LF) control mice. Significantly decreased DAT densities were observed in cDR mice compared to cDIO and LF mice, primarily in the nucleus accumbens, striatal and hypothalamic regions. D2 receptor density was significantly lower in the rostral part of caudate putamen in cDIO mice compared to cDR and LF mice.

[1]  J. Lakoski,et al.  Restricted feeding with scheduled sucrose access results in an upregulation of the rat dopamine transporter. , 2003, American journal of physiology. Regulatory, integrative and comparative physiology.

[2]  J. W. Aldridge,et al.  Hyperdopaminergic mutant mice have higher "wanting" but not "liking" for sweet rewards. , 2004, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[3]  D. Figlewicz,et al.  Food Deprivation Decreases mRNA and Activity of the Rat Dopamine Transporter , 1998, Neuroendocrinology.

[4]  L. Zhang,et al.  Hypothalamic dopamine and serotonin in the regulation of food intake. , 2000, Nutrition.

[5]  R. Wise,et al.  Brain dopamine and reward. , 1989, Annual review of psychology.

[6]  N. Volkow,et al.  “Nonhedonic” food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect , 2002, Synapse.

[7]  S. Fetissov,et al.  Dopamine and serotonin VMN release is related to feeding status in obese and lean Zucker rats , 2000, Neuroreport.

[8]  F. Delis,et al.  Dopamine receptor and transporter levels are altered in the brain of Purkinje Cell Degeneration mutant mice , 2004, Neuroscience.

[9]  M. Low,et al.  Dopamine D2 Receptor‐Deficient Mice Exhibit Decreased Dopamine Transporter Function but No Changes in Dopamine Release in Dorsal Striatum , 1999, Journal of neurochemistry.

[10]  B. Levin,et al.  Defense of differfing body weight set points in diet-induced obese and resistant rats. , 1998, American journal of physiology. Regulatory, integrative and comparative physiology.

[11]  S. Woods,et al.  Intraventricular insulin increases dopamine transporter mRNA in rat VTA/substantia nigra , 1994, Brain Research.

[12]  S. Kulkarni,et al.  Studies on modulation of feeding behavior by atypical antipsychotics in female mice , 2002, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[13]  R. Palmiter,et al.  Dopamine is required for hyperphagia in Lepob/ob mice , 2000, Nature Genetics.

[14]  S. Amara,et al.  Neurotransmitter transporters: recent progress. , 1993, Annual review of neuroscience.

[15]  L. Storlien,et al.  The level of NPY receptor mRNA expression in diet-induced obese and resistant mice. , 2003, Brain research. Molecular brain research.

[16]  George Paxinos,et al.  The Mouse Brain in Stereotaxic Coordinates , 2001 .

[17]  Thomas J. H. Chen,et al.  The Reward Deficiency Syndrome: A Biogenetic Model for the Diagnosis and Treatment of Impulsive, Addictive and Compulsive Behaviors , 2000, Journal of psychoactive drugs.

[18]  P. G. Clifton,et al.  Meal patterns of free feeding rats treated with clozapine, olanzapine, or haloperidol , 2002, Pharmacology Biochemistry and Behavior.

[19]  Jean Logan,et al.  Brain dopamine and obesity , 2001, The Lancet.

[20]  K. Zavitsanou,et al.  Differential expression of dopamine D2 and D4 receptor and tyrosine hydroxylase mRNA in mice prone, or resistant, to chronic high-fat diet-induced obesity. , 2005, Brain research. Molecular brain research.

[21]  I. McGregor,et al.  Increased Anxiety 3 Months after Brief Exposure to MDMA (‘Ecstasy’) in Rats: Association with Altered 5-HT Transporter and Receptor Density , 2003, Neuropsychopharmacology.

[22]  N. Sato,et al.  Altered ambulatory activity and related brain monoamine metabolism in genetically obese Zucker rats. , 2009, Experimental and clinical endocrinology.

[23]  A. Lawrence,et al.  5-HT transporter sites and 5-HT1A and 5-HT3 receptors in Fawn-Hooded rats: a quantitative autoradiography study. , 2000, Alcoholism, clinical and experimental research.

[24]  J. Porter,et al.  Decreased striatal D2 dopamine receptors in obese Zucker rats: changes during aging , 1992, Brain Research.

[25]  Xu-Feng Huang,et al.  5-HT2A/2C receptor and 5-HT transporter densities in mice prone or resistant to chronic high-fat diet-induced obesity: a quantitative autoradiography study , 2004, Brain Research.

[26]  B. G. Hoebel.  Brain neurotransmitters in food and drug reward. , 1985, The American journal of clinical nutrition.

[27]  Akira Tsuda,et al.  Eating and drinking cause increased dopamine release in the nucleus accumbens and ventral tegmental area in the rat: Measurement by in vivo microdialysis , 1992, Neuroscience Letters.

[28]  P. G. Reeves,et al.  AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. , 1993, The Journal of nutrition.

[29]  A. Galli,et al.  Selective Decreases in Amphetamine Self-Administration and Regulation of Dopamine Transporter Function in Diabetic Rats , 2003, Neuroendocrinology.

[30]  R. Palmiter,et al.  Viral Gene Delivery Selectively Restores Feeding and Prevents Lethality of Dopamine-Deficient Mice , 1999, Neuron.