A randomized, placebo-controlled, double-blind clinical trial of rikkunshito for patients with non-erosive reflux disease refractory to proton-pump inhibitor: the G-PRIDE study

[1]  K. Tominaga,et al.  Kampo medicines for gastrointestinal tract disorders: a review of basic science and clinical evidence and their future application , 2013, Journal of Gastroenterology.

[2]  K. Tominaga,et al.  High Prevalence of Gastroesophageal Reflux Symptoms in Patients with Non-Alcoholic Fatty Liver Disease Associated with Serum Levels of Triglyceride and Cholesterol but Not Simple Visceral Obesity , 2012, Digestion.

[3]  M. Asaka,et al.  Impaired ghrelin signaling is associated with gastrointestinal dysmotility in rats with gastroesophageal reflux disease. , 2012, American journal of physiology. Gastrointestinal and liver physiology.

[4]  D. Sifrim,et al.  Diagnosis and management of patients with reflux symptoms refractory to proton pump inhibitors , 2012, Gut.

[5]  H. Sugihara,et al.  The herbal medicine rikkunshito exhibits strong and differential adsorption properties for bile salts. , 2012, Experimental and therapeutic medicine.

[6]  Mio Tanaka,et al.  Rikkunshito improves symptoms in PPI-refractory GERD patients: a prospective, randomized, multicenter trial in Japan , 2012, Journal of Gastroenterology.

[7]  A. Asakawa,et al.  Potentiation of ghrelin signaling attenuates cancer anorexia–cachexia and prolongs survival , 2011, Translational Psychiatry.

[8]  M. Hongo,et al.  Effect of rikkunshito on gastric sensorimotor function under distention , 2011, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[9]  M. Hongo.  Epidemiology of FGID symptoms in Japanese general population with reference to life style , 2011, Journal of gastroenterology and hepatology.

[10]  K. Tominaga,et al.  The Traditional Japanese Medicine Rikkunshito Promotes Gastric Emptying via the Antagonistic Action of the 5-HT3 Receptor Pathway in Rats , 2011, Evidence-based complementary and alternative medicine : eCAM.

[11]  T. Kaptchuk,et al.  Meta‐analysis: the effects of placebo treatment on gastro‐oesophageal reflux disease , 2010, Alimentary pharmacology & therapeutics.

[12]  K. Tominaga,et al.  Prevalence of overlaps between GERD, FD and IBS and impact on health‐related quality of life , 2010, Journal of gastroenterology and hepatology.

[13]  T. Tomita,et al.  Rikkunshito, a traditional Japanese medicine, may relieve abdominal symptoms in rats with experimental esophagitis by improving the barrier function of epithelial cells in esophageal mucosa , 2010, Journal of Gastroenterology.

[14]  Yuriko Tanaka,et al.  The prokinetic effect of mosapride citrate combined with omeprazole therapy improves clinical symptoms and gastric emptying in PPI-resistant NERD patients with delayed gastric emptying , 2010, Journal of Gastroenterology.

[15]  R. Fass,et al.  Nonerosive Reflux Disease (NERD) - An Update , 2010, Journal of neurogastroenterology and motility.

[16]  Myung-Gyu Choi,et al.  Relationship between Psychological Factors and Quality of Life in Subtypes of Gastroesophageal Reflux Disease , 2009, Gut and liver.

[17]  K. Tominaga,et al.  Efficacy of the 5-HT1A Agonist Tandospirone Citrate in Improving Symptoms of Patients With Functional Dyspepsia: A Randomized Controlled Trial , 2009, The American Journal of Gastroenterology.

[18]  T. Usuda,et al.  Scoring of reflux symptoms associated with scleroderma and the usefulness of rabeprazole. , 2009, Clinical and experimental rheumatology.

[19]  Y. Fujiwara,et al.  Epidemiology and clinical characteristics of GERD in the Japanese population , 2009, Journal of Gastroenterology.

[20]  G. Coté,et al.  Potential adverse effects of proton pump inhibitors , 2008, Current gastroenterology reports.

[21]  M. Asaka,et al.  Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism. , 2008, Gastroenterology.

[22]  K. Chayama,et al.  Strategy for treatment of nonerosive reflux disease in Asia. , 2008, World journal of gastroenterology.

[23]  M. Fukuzawa,et al.  Effects of rikkunshito on the clinical symptoms and esophageal acid exposure in children with symptomatic gastroesophageal reflux , 2007, Pediatric Surgery International.

[24]  R. Fass.  Symptom Assessment Tools for Gastroesophageal Reflux Disease (GERD) Treatment , 2007, Journal of clinical gastroenterology.

[25]  R. Mittal,et al.  Review article: acidity and volume of the refluxate in the genesis of gastro‐oesophageal reflux disease symptoms , 2007, Alimentary pharmacology & therapeutics.

[26]  K. Tominaga,et al.  Comparison of gastrointestinal symptoms and psychological factors of functional dyspepsia to peptic ulcer or panic disorder patients , 2007, Inflammopharmacology.

[27]  J. Dent,et al.  The Montreal Definition and Classification of Gastroesophageal Reflux Disease: A Global Evidence-Based Consensus , 2006, The American Journal of Gastroenterology.

[28]  T. Matsui,et al.  A prospective study of the prevalence of gastroesophageal reflux disease and confounding factors , 2005, Journal of Gastroenterology.

[29]  Fumihiko Katagiri,et al.  Effects of some kampo medicines on plasma levels of neuropeptide Y under venipuncture stress. , 2005, Biological & pharmaceutical bulletin.

[30]  R. Fass,et al.  Systematic review: proton‐pump inhibitor failure in gastro‐oesophageal reflux disease – where next? , 2005, Alimentary pharmacology & therapeutics.

[31]  Y. Kinoshita,et al.  Prevalence of endoscopically negative and positive gastroesophageal reflux disease in the Japanese , 2005, Scandinavian journal of gastroenterology.

[32]  K. Fujimoto,et al.  Review article: prevalence and epidemiology of gastro‐oesophageal reflux disease in Japan , 2004, Alimentary pharmacology & therapeutics.

[33]  O. Kawamura,et al.  Development and evaluation of FSSG: frequency scale for the symptoms of GERD , 2004, Journal of Gastroenterology.

[34]  B. Dean,et al.  Effectiveness of proton pump inhibitors in nonerosive reflux disease. , 2004, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[35]  T. Ohkusa,et al.  Oesophageal hypersensitivity in Japanese patients with non‐erosive gastro‐oesophageal reflux diseases , 2004, Alimentary pharmacology & therapeutics.

[36]  P. Malfertheiner,et al.  Quality of life in relation to symptoms in patients with gastro‐oesophageal reflux disease — an analysis based on the ProGERD initiative , 2003, Alimentary pharmacology & therapeutics.

[37]  D. Castell,et al.  Baclofen decreases acid and non‐acid post‐prandial gastro‐oesophageal reflux measured by combined multichannel intraluminal impedance and pH , 2003, Alimentary pharmacology & therapeutics.

[38]  E. Xenos.  The role of esophageal motility and hiatal hernia in esophageal exposure to acid , 2002, Surgical Endoscopy And Other Interventional Techniques.

[39]  R. Mittal,et al.  Sustained esophageal contraction: a motor correlate of heartburn symptom. , 2001, American journal of physiology. Gastrointestinal and liver physiology.

[40]  Y. Kashiwagi,et al.  Proportion of reflux esophagitis in 6010 Japanese adults: prospective evaluation by endoscopy , 1999, Journal of Gastroenterology.

[41]  B. Naliboff,et al.  Differential effect of long-term esophageal acid exposure on mechanosensitivity and chemosensitivity in humans. , 1998, Gastroenterology.

[42]  R. Kozarek,et al.  The gastroesophageal flap valve: in vitro and in vivo observations. , 1996, Gastrointestinal endoscopy.

[43]  J. Dent,et al.  Relation between oesophageal acid exposure and healing of oesophagitis with omeprazole in patients with severe reflux oesophagitis. , 1996, Gut.

[44]  R. Fass,et al.  Step-by-step management of refractory gastresophageal reflux disease. , 2013, Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus.

[45]  R. Fass.  Proton-Pump Inhibitor Therapy in Patients with Gastro-Oesophageal Reflux Disease , 2012, Drugs.

[46]  H. Imamura,et al.  Efficacy of Rikkunshito, a traditional Japanese medicine (Kampo), in treating functional dyspepsia. , 2010, Internal medicine.

[47]  M. Asaka,et al.  Rikkunshito ameliorates the aging-associated decrease in ghrelin receptor reactivity via phosphodiesterase III inhibition. , 2010, Endocrinology.

[48]  J. Richter,et al.  Internet use in rheumatology outpatients in 2006: gender less important. , 2009, Clinical and experimental rheumatology.

[49]  M. Nomura,et al.  Effects of rikkunshi-to, a traditional Japanese medicine, on the delay of gastric emptying induced by N(G)-nitro-L-arginine. , 2005, Journal of pharmacological sciences.

[50]  H. Itoh,et al.  Some gastrointestinal function regulatory Kampo medicines have modulatory effects on human plasma adrenocorticotropic hormone and cortisol levels with continual stress exposure. , 2003, Biological & pharmaceutical bulletin.

[51]  K. Higuchi,et al.  Liu-Jun-Zi-Tang, a kampo medicine, promotes adaptive relaxation in isolated guinea pig stomachs. , 1999, Drugs under experimental and clinical research.