Genetics of food intake and eating behavior phenotypes in humans.

This review summarizes the research advances of the past decade regarding the role of human genetic differences in energy and nutrient intake as well as in eating behavior phenotypes and selected eating disorders. The evidence for familial aggregation and heritability based on twin and nuclear family study designs is summarized. Genome-wide linkage scans and quantitative trait loci identified to date are discussed. DNA sequence variants in candidate genes are reviewed. Single genes associated with classical eating disorders are also incorporated. Epigenetic events will need to be incorporated in future studies designed to investigate the effects of DNA variants on dietary phenotypes. Understanding the relative contribution of global genetic variation and of DNA sequence variants in specific genes is important in the effort to influence dietary habits in a healthier direction.

[1]  W. Kaye,et al.  Controlled family study of anorexia nervosa and bulimia nervosa: evidence of shared liability and transmission of partial syndromes. , 2000, The American journal of psychiatry.

[2]  S. O’Rahilly,et al.  Congenital leptin deficiency is associated with severe early-onset obesity in humans , 1997, Nature.

[3]  T. Sellers,et al.  Can dietary intake patterns account for the familial aggregation of disease? Evidence from adult siblings living apart , 1991, Genetic epidemiology.

[4]  B. Devlin,et al.  Linkage analysis of anorexia nervosa incorporating behavioral covariates. , 2002, Human molecular genetics.

[5]  J. Hebebrand,et al.  Genetic Risk Factors in Eating Disorders , 2004, American journal of pharmacogenomics : genomics-related research in drug development and clinical practice.

[6]  P. Gorwood,et al.  5-HT2A gene promoter polymorphism as a modifying rather than a vulnerability factor in anorexia nervosa , 2002, European Psychiatry.

[7]  D. Rao,et al.  Lifestyle factors in monozygotic and dizygotic twins , 1988, Genetic epidemiology.

[8]  M. Gratacós,et al.  Contribution of NTRK2 to the genetic susceptibility to anorexia nervosa, Harm avoidance and minimum body mass index , 2005, Molecular Psychiatry.

[9]  Paul J. Harrison,et al.  Twin studies and the etiology of eating disorders. , 1999, The International journal of eating disorders.

[10]  J. Rice,et al.  Familial resemblance in energy intake: contribution of genetic and environmental factors. , 1988, The American journal of clinical nutrition.

[11]  C. Bulik,et al.  Family Environment and Psychiatric History in Women with Binge-eating Disorder and Obese Controls , 1997, Behaviour Change.

[12]  L. Eaves,et al.  Genetic and environmental influences on eating patterns of twins aged >/=50 y. , 1999, The American journal of clinical nutrition.

[13]  M. Yeager,et al.  Candidate genes for anorexia nervosa in the 1p33–36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa* , 2003, Molecular Psychiatry.

[14]  D. Collier,et al.  Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations. , 2004, Human molecular genetics.

[15]  J. D. Castro.  Heritability of Hunger Relationships With Food Intake in Free-Living Humans , 1999, Physiology & Behavior.

[16]  S. Garn,et al.  Living together as a factor in family-line resemblances. , 1979, Human biology.

[17]  Graham M Lord,et al.  Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. , 2002, The Journal of clinical investigation.

[18]  J. D. Castro.  A twin study of genetic and environmental influences on the intake of fluids and beverages , 1993, Physiology & Behavior.

[19]  C. Bell,et al.  Genome scan for human obesity and linkage to markers in 20q13. , 1999, American journal of human genetics.

[20]  J. D. Castro.  Independence of genetic influences on body size, daily intake, and meal patterns of humans , 1993, Physiology & Behavior.

[21]  A. Rissanen,et al.  Genetic and Environmental Factors in Breakfast Eating Patterns , 2004, Behavior genetics.

[22]  G Siest,et al.  5-HT2A receptor gene polymorphism is associated with food and alcohol intake in obese people , 2000, International Journal of Obesity.

[23]  A. Pickles,et al.  Bulimic symptoms in the virginia twin study of adolescent behavioral development: correlates, comorbidity, and genetics , 2002, Biological Psychiatry.

[24]  B. Neale,et al.  A twin study of dietary restraint, disinhibition and hunger: an examination of the eating inventory (three factor eating questionnaire). , 2003, Twin research : the official journal of the International Society for Twin Studies.

[25]  T. Spector,et al.  Epigenetic differences arise during the lifetime of monozygotic twins. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[26]  Jan Karlsson,et al.  Genetic and environmental influences on eating behavior: the Swedish Young Male Twins Study. , 2005, The American journal of clinical nutrition.

[27]  J. D. Castro.  Behavioral genetics of food intake regulation in free-living humans , 1999 .

[28]  J. D. Castro.  Heritability of diurnal changes in food intake in free-living humans. , 2001 .

[29]  Braxton D Mitchell,et al.  Eating behavior in the Old Order Amish: heritability analysis and a genome-wide linkage analysis. , 2002, The American journal of clinical nutrition.

[30]  A. Stunkard,et al.  The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. , 1985, Journal of psychosomatic research.

[31]  Caryn Lerman,et al.  Relation between food reinforcement and dopamine genotypes and its effect on food intake in smokers. , 2004, The American journal of clinical nutrition.

[32]  C. Bouchard,et al.  A genome-wide linkage scan for dietary energy and nutrient intakes: the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) Family Study. , 2004, The American journal of clinical nutrition.

[33]  S. Bacanu,et al.  Significant linkage on chromosome 10p in families with bulimia nervosa. , 2003, American journal of human genetics.

[34]  M. Neale,et al.  Evidence for Genetic Influences on Human Energy Intake: Results from a Twin Study Using Measured Observations , 1999, Behavior genetics.

[35]  A. Prentice,et al.  Effects of recombinant leptin therapy in a child with congenital leptin deficiency. , 1999, The New England journal of medicine.

[36]  G. Beauchamp,et al.  Heritable Variation in Food Preferences and Their Contribution to Obesity , 1997, Behavior genetics.

[37]  H. Hoek,et al.  The incidence and prevalence of anorexia nervosa and bulimia nervosa in primary care , 1991, Psychological Medicine.

[38]  K. Kendler,et al.  Anorexia nervosa and anorexic-like syndromes in a population-based female twin sample. , 1995, The American journal of psychiatry.

[39]  G. Siest,et al.  Family resemblance in breakfast energy intake: the Stanislas Family Study , 2002, European Journal of Clinical Nutrition.

[40]  P. Sullivan,et al.  Heritability of binge-eating and broadly defined bulimia nervosa , 1998, Biological Psychiatry.

[41]  F. Stare,et al.  COMPARISONS OF SIBLINGS IN BOSTON AND IRELAND. , 1964, Journal of the American Dietetic Association.

[42]  J. D. Castro.  Genes and Environment Have Gender-Independent Influences on the Eating and Drinking of Free-Living Humans , 1998, Physiology & Behavior.

[43]  R. Krauss,et al.  Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[44]  Claude Bouchard,et al.  Neuromedin beta: a strong candidate gene linking eating behaviors and susceptibility to obesity. , 2004, American Journal of Clinical Nutrition.

[45]  P. Gorwood,et al.  The human genetics of anorexia nervosa. , 2003, European journal of pharmacology.

[46]  D. Collier,et al.  Association of BDNF with restricting anorexia nervosa and minimum body mass index: a family-based association study of eight European populations , 2005, European Journal of Human Genetics.

[47]  J. D. Castro.  When identical twins differ: an analysis of intrapair differences in the spontaneous eating behavior and attitudes of free-living monozygotic twins , 2004, Physiology & Behavior.

[48]  D. C. Jm,et al.  How genes control real world intake: palatability--intake relationships. , 2001 .

[49]  S. O’Rahilly,et al.  A de novo mutation affecting human TrkB associated with severe obesity and developmental delay , 2004, Nature Neuroscience.

[50]  Dan J Stein,et al.  Familial aggregation of eating disorders: results from a controlled family study of bulimia nervosa. , 1999, The International journal of eating disorders.

[51]  Tim Cheetham,et al.  Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. , 2003, The New England journal of medicine.

[52]  Tao Li,et al.  Association of the 5-HT2c gene with susceptibility and minimum body mass index in anorexia nervosa , 2003, Neuroreport.

[53]  R. Hamman,et al.  Genetic variation in uncoupling protein 3 is associated with dietary intake and body composition in females. , 2004, Metabolism: clinical and experimental.

[54]  P. Sullivan,et al.  Genetic and environmental contributions to obesity and binge eating. , 2003, The International journal of eating disorders.

[55]  J. M. de Castro,et al.  Influence of heredity on dietary restraint, disinhibition, and perceived hunger in humans. , 2005, Nutrition.

[56]  G. Siest,et al.  Polymorphism of the 5-HT2A receptor gene and food intakes in children and adolescents: the Stanislas Family Study , 2005 .

[57]  J. Maccluer,et al.  Familial aggregation of nutrient intake and physical activity: results from the San Antonio Family Heart Study. , 2003, Annals of epidemiology.

[58]  L. Lissner,et al.  Genetic effects on weight change and food intake in Swedish adult twins. , 1999, The American journal of clinical nutrition.

[59]  T. Bouchard,et al.  Genetic and environmental influences on self-reported diet: a reared-apart twin study , 1998, Physiology & Behavior.

[60]  J. D. Castro.  Independence of heritable influences on the food intake of free-living humans. , 2002 .

[61]  M. Gratacós,et al.  Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type , 2003, Molecular Psychiatry.

[62]  Susan L. Johnson,et al.  Familial aggregation of energy intake in children. , 2004, The American journal of clinical nutrition.

[63]  C. Langefeld,et al.  Further evidence for a susceptibility locus for type 2 diabetes on chromosome 20q13.1-q13.2. , 2000, Diabetes.

[64]  M. Feinleib,et al.  A twin analysis of dietary intake: Evidence for a need to control for possible environmental differences in MZ and DZ twins , 1978, Behavior genetics.

[65]  A. Lluch,et al.  Family resemblance in energy and macronutrient intakes: the Stanislas Family Study. , 1996, International journal of epidemiology.

[66]  A. Rissanen,et al.  Acquired preference especially for dietary fat and obesity: a study of weight-discordant monozygotic twin pairs , 2002, International Journal of Obesity.

[67]  C. Bouchard,et al.  Two ethnic-specific polymorphisms in the human Agouti-related protein gene are associated with macronutrient intake. , 2005, The American journal of clinical nutrition.

[68]  C. Bulik,et al.  Genetic and environmental influences on binge eating in the absence of compensatory behaviors: a population-based twin study. , 2004, The International journal of eating disorders.

[69]  J. Blangero,et al.  Quantitative trait locus determining dietary macronutrient intakes is located on human chromosome 2p22. , 2004, The American journal of clinical nutrition.

[70]  C. Bouchard,et al.  Familial resemblance in eating behaviors in men and women from the Quebec Family Study. , 2005, Obesity research.

[71]  J. D. Castro.  Inheritance of Premeal Stomach Content Influences on Food Intake in Free Living Humans , 1999, Physiology & Behavior.

[72]  G. Beaton,et al.  Source of variance in 24-hour dietary recall data: implications for nutrition study design and interpretation. Carbohydrate sources, vitamins, and minerals. , 1983, The American journal of clinical nutrition.

[73]  M Strober,et al.  Evidence for a susceptibility gene for anorexia nervosa on chromosome 1. , 2002, American journal of human genetics.

[74]  N. Martin,et al.  The structure of genetic and environmental risk factors for three measures of disordered eating , 1999, Psychological Medicine.

[75]  P. Sullivan,et al.  Twin studies of eating disorders: a review. , 2000, The International journal of eating disorders.

[76]  M. Luo,et al.  A genome-wide search for Type II diabetes susceptibility genes in Chinese Hans , 2001, Diabetologia.

[77]  S. O’Rahilly,et al.  Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy. , 2004, The Journal of clinical endocrinology and metabolism.

[78]  Abraham Weizman,et al.  Heritability, genetics and association findings in anorexia nervosa. , 2002, The Israel journal of psychiatry and related sciences.

[79]  J. Wardle,et al.  Food and activity preferences in children of lean and obese parents , 2001, International Journal of Obesity.