论文信息 - New Syntheses of Fervenulin (1,3-Dimethyl-7-azalumazine) and Analogs

New Syntheses of Fervenulin (1,3-Dimethyl-7-azalumazine) and Analogs

A new, convenient method for the synthesis of fervenulin and its derivatives on the basis of the condensation of 6-amino-5-nitrosouracils and aldehyde hydrazones is described. A transformation of toxoflavins into fervenulins via 1-demethyltoxoflavins is also described. The alkylation of 1-demethyltoxoflavin with several alcohols in the presence of diethyl azodicarboxylate and triphenylphosphine gave the corresponding fervenulin homologs.

T. Nagamatsu | F. Yoneda

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