Koninginin W, a New Polyketide from the Endophytic Fungus Trichoderma koningiopsis YIM PH30002

A new compound named koninginin W (1) and four known polyketides (2–5) were isolated from endophytic fungus Trichoderma koningiopsis YIM PH30002 of Panax notoginseng. The structures of 1 ‐ 5, including absolute configuration of 1, were elucidated on the detailed analysis of the HR‐ESI‐MS, 1D and 2D NMR, and X‐ray crystallographic data. Koninginin W (1) presented weak antibacterial activity against Escherichia coli, Bacillus subtilis and Salmonella typhimurium.

[1]  S. Heilbronner,et al.  Staphylococcus lugdunensis: a Skin Commensal with Invasive Pathogenic Potential , 2020, Clinical Microbiology Reviews.

[2]  B. Xie,et al.  Bioactive Secondary Metabolites from Trichoderma spp. against Phytopathogenic Bacteria and Root-Knot Nematode , 2020, Microorganisms.

[3]  S. Lumyong,et al.  First report of secondary metabolites, Violaceol I and Violaceol II produced by endophytic fungus, Trichoderma polyalthiae and their antimicrobial activity , 2020 .

[4]  Ning Wang,et al.  Panax notoginseng for Inflammation-Related Chronic Diseases: A Review on the Modulations of Multiple Pathways. , 2018, The American journal of Chinese medicine.

[5]  Xiu-li Yin,et al.  Halogenated and Nonhalogenated Metabolites from the Marine-Alga-Endophytic Fungus Trichoderma asperellum cf44-2 , 2018, Marine drugs.

[6]  Xiao‐Ming Li,et al.  Antimicrobial polyketides from Trichoderma koningiopsis QA-3, an endophytic fungus obtained from the medicinal plant Artemisia argyi , 2017 .

[7]  Xingzhong Liu,et al.  Trichoderpyrone, a Unique Polyketide Hybrid with a Cyclopentenone-Pyrone Skeleton from the Plant Endophytic Fungus Trichoderma gamsii. , 2017, Journal of natural products.

[8]  Yabin Yang,et al.  Koninginins R-S from the endophytic fungus Trichoderma koningiopsis , 2017, Natural product research.

[9]  Hui-lin Guan,et al.  Endophytic Trichoderma gamsii YIM PH30019: a promising biocontrol agent with hyperosmolar, mycoparasitism, and antagonistic activities of induced volatile organic compounds on root-rot pathogenic fungi of Panax notoginseng , 2015, Journal of ginseng research.

[10]  Yabin Yang,et al.  Koningiopisins A–H, Polyketides with Synergistic Antifungal Activities from the Endophytic Fungus Trichoderma koningiopsis , 2015, Planta Medica.

[11]  Hui-lin Guan,et al.  Salt tolerance of endophytic Trichoderma koningiopsis YIM PH30002 and its volatile organic compounds (VOCs) allelopathic activity against phytopathogens associated with Panax notoginseng , 2015, Annals of Microbiology.

[12]  J. Imhoff,et al.  Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106 , 2014, Marine drugs.

[13]  P. Proksch,et al.  Fungal endophytes: unique plant inhabitants with great promises , 2011, Applied Microbiology and Biotechnology.

[14]  Y. Tong,et al.  Trichodermaketones A-D and 7-O-methylkoninginin D from the marine fungus Trichoderma koningii. , 2010, Journal of natural products.

[15]  Zhiqin Wang,et al.  Total Synthesis of Koninginin D, B and E , 2001 .

[16]  Gang Liu,et al.  First total synthesis of (+)-koninginin D , 1999 .