Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome

[1]  S. McMahon,et al.  Immunocytochemical Localization of trkA Receptors in Chemically Identified Subgroups of Adult Rat Sensory Neurons , 1995, The European journal of neuroscience.

[2]  David J Anderson,et al.  Transient expression of the bHLH factor neurogenin-2 marks a subpopulation of neural crest cells biased for a sensory but not a neuronal fate , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[3]  M. Greenberg,et al.  Neurogenin Promotes Neurogenesis and Inhibits Glial Differentiation by Independent Mechanisms , 2001, Cell.

[4]  Karen Gale,et al.  Spinal cord contusion in the rat: Behavioral analysis of functional neurologic impairment , 1985, Experimental Neurology.

[5]  M. Filbin,et al.  cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury , 2004, Nature Medicine.

[6]  Martin E Schwab,et al.  The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats , 2004, Nature Neuroscience.

[7]  K. Tomita,et al.  Mammalian achaete–scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system , 2000, The EMBO journal.

[8]  A. Manira,et al.  Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[9]  F. Guillemot Vertebrate bHLH genes and the determination of neuronal fates. , 1999, Experimental cell research.

[10]  H. Dai,et al.  Axonal Regeneration and Functional Recovery after Complete Spinal Cord Transection in Rats by Delayed Treatment with Transplants and Neurotrophins , 2001, The Journal of Neuroscience.

[11]  T. Hökfelt,et al.  Calcitonin Gene‐Related Peptide in the Brain, Spinal Cord, and Some Peripheral Systems a , 1992, Annals of the New York Academy of Sciences.

[12]  C. Hulsebosch,et al.  Alleviation of mechanical and thermal allodynia by CGRP8-37 in a rodent model of chronic central pain , 2000, Pain.

[13]  M. Beattie,et al.  Spinal cord injury produced by consistent mechanical displacement of the cord in rats: behavioral and histologic analysis. , 1992, Journal of neurotrauma.

[14]  C. Spenger,et al.  Numb rats walk – a behavioural and fMRI comparison of mild and moderate spinal cord injury , 2003, The European journal of neuroscience.

[15]  I. Griffiths,et al.  Nerve fibres in spinal cord impact injuries Part 1. Changes in the myelin sheath during the initial 5 weeks , 1983, Journal of the Neurological Sciences.

[16]  R. Dubner,et al.  A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia , 1987, Pain.

[17]  M. Tuszynski,et al.  Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury , 2003, Experimental Neurology.

[18]  James W. Fawcett,et al.  Chondroitinase ABC promotes functional recovery after spinal cord injury , 2002, Nature.

[19]  A. Scheibel,et al.  Degeneration and regeneration of the nervous system , 1960 .

[20]  M. Carlén,et al.  Gene delivery to adult neural stem cells. , 2002, Experimental cell research.

[21]  J. Widenfalk,et al.  Repair of peripheral nerve transections with fibrin sealant containing neurotrophic factors , 2003, Experimental Neurology.

[22]  M. Schwab,et al.  Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors , 1995, Nature.

[23]  J. Kocsis,et al.  Transplantation of Clonal Neural Precursor Cells Derived from Adult Human Brain Establishes Functional Peripheral Myelin in the Rat Spinal Cord , 2001, Experimental Neurology.

[24]  M. Jönhagen,et al.  Intracerebroventricular infusion of nerve growth factor induces pain-like response in rats , 2000, Neuroscience Letters.

[25]  H. Okano,et al.  Transplantation of in vitro‐expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats , 2002, Journal of neuroscience research.

[26]  Stephen G. Waxman,et al.  Demyelination in spinal cord injury , 1989, Journal of the Neurological Sciences.

[27]  D. Basso,et al.  A sensitive and reliable locomotor rating scale for open field testing in rats. , 1995, Journal of neurotrauma.

[28]  R. Bunge,et al.  Observations on the pathology of several types of human spinal cord injury, with emphasis on the astrocyte response to penetrating injuries. , 1997, Advances in neurology.

[29]  D. D.-B.,et al.  Degeneration and Regeneration of the Nervous System , 1930, Nature.

[30]  L. Weaver,et al.  NGF message and protein distribution in the injured rat spinal cord , 2004, Experimental Neurology.

[31]  M J West,et al.  Stereological length estimation using spherical probes , 2002, Journal of microscopy.

[32]  J. Winkler,et al.  Adult neural progenitor cell grafts survive after acute spinal cord injury and integrate along axonal pathways , 2003, The European journal of neuroscience.

[33]  C. Hulsebosch,et al.  Chronic central pain after spinal cord injury. , 1997, Journal of neurotrauma.

[34]  B. Winblad,et al.  Intracerebroventricular Infusion of Nerve Growth Factor in Three Patients with Alzheimer’s Disease , 1998, Dementia and Geriatric Cognitive Disorders.

[35]  R. Franklin,et al.  Local recruitment of remyelinating cells in the repair of demyelination in the central nervous system , 1997, Journal of neuroscience research.

[36]  M. Ingvar,et al.  Functional MRI at 4.7 Tesla of the Rat Brain during Electric Stimulation of Forepaw, Hindpaw, or Tail in Single- and Multislice Experiments , 2000, Experimental Neurology.

[37]  S. Waxman,et al.  Transplantation of glial cells enhances action potential conduction of amyelinated spinal cord axons in the myelin-deficient rat. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[38]  H. Gundersen Stereology of arbitrary particles * , 1986, Journal of microscopy.

[39]  C. Hulsebosch,et al.  Spinal Cord Injury and Anti-NGF Treatment Results in Changes in CGRP Density and Distribution in the Dorsal Horn in the Rat , 1997, Experimental Neurology.

[40]  J. Goldman,et al.  Endogenous Progenitors Remyelinate Demyelinated Axons in the Adult CNS , 1997, Neuron.

[41]  J. Mcdonald,et al.  Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord , 1999, Nature Medicine.

[42]  Robert H Miller,et al.  Transplantation of oligodendrocyte precursors and sonic hedgehog results in improved function and white matter sparing in the spinal cords of adult rats after contusion. , 2003, The spine journal : official journal of the North American Spine Society.

[43]  W. Young,et al.  Central axons in injured cat spinal cord recover electrophysiological function following remyelination by Schwann cells , 1989, Journal of the Neurological Sciences.

[44]  R. Nashmi,et al.  Changes in axonal physiology and morphology after chronic compressive injury of the rat thoracic spinal cord , 2001, Neuroscience.

[45]  M. Nieto,et al.  Neural bHLH Genes Control the Neuronal versus Glial Fate Decision in Cortical Progenitors , 2001, Neuron.

[46]  Jonas Frisén,et al.  Identification of a Neural Stem Cell in the Adult Mammalian Central Nervous System , 1999, Cell.

[47]  L. Olson Regeneration in the adult central nervous system: Experimental repair strategies , 1997, Nature Medicine.

[48]  R. Adkins,et al.  Pain and depression in acute traumatic spinal cord injury: origins of chronic problematic pain? , 1996, Archives of physical medicine and rehabilitation.

[49]  William D. Willis,et al.  Sensory Mechanisms of the Spinal Cord , 1979, Springer US.