An elastically compressible phantom material with mechanical and x-ray attenuation properties equivalent to breast tissue

We have developed a novel phantom material: a solution of polyvinyl alcohol (PVAL) in ethanol and water, freeze-thawed to produce a solid yet elastically compressible gel. The x-ray attenuation and mechanical properties of these gels are compared with published measurements of breast tissue. Gels with PVAL concentrations from 5 to 20% w/v were produced. The linear x-ray attenuation coefficients of these gels range from 0.76 to 0.86 cm(-1) at 17.5 keV, increasing with PVAL concentration. These values are very similar to the published values of breast tissue at this energy, 0.8-0.9 cm(-1). Under compression cancerous breast tissue is approximately ten times stiffer than healthy breast tissue. The Young's moduli of the gels increase with PVAL concentration. Varying the PVAL concentration from 7.5 to 20% w/v produces gels with Young's moduli from 20 to 220 kPa at 15% strain. These values are characteristic of normal and cancerous breast tissue, respectively.

[1]  Radhika Sivaramakrishna,et al.  Breast image registration techniques: a survey , 2006, Medical and Biological Engineering and Computing.

[2]  Dimitris N. Metaxas,et al.  Methods for modeling and predicting mechanical deformations of the breast under external perturbations , 2002, Medical Image Anal..

[3]  J. H. Hubbell,et al.  XCOM : Photon Cross Sections Database , 2005 .

[4]  Jeremy C Hebden,et al.  A soft deformable tissue-equivalent phantom for diffuse optical tomography , 2006, Physics in medicine and biology.

[5]  Y. Ikada,et al.  Preparation of transparent poly(vinyl alcohol) hydrogel , 1989 .

[6]  W E Bolch,et al.  Tissue-equivalent materials for construction of tomographic dosimetry phantoms in pediatric radiology. , 2003, Medical physics.

[7]  M Fink,et al.  Imaging anisotropic and viscous properties of breast tissue by magnetic resonance‐elastography , 2005, Magnetic resonance in medicine.

[8]  R L Ehman,et al.  Tissue characterization using magnetic resonance elastography: preliminary results. , 2000, Physics in medicine and biology.

[9]  T. Krouskop,et al.  Elastic Moduli of Breast and Prostate Tissues under Compression , 1998, Ultrasonic imaging.

[10]  W. Kaiser,et al.  Model-based registration of X-ray mammograms and MR images of the female breast , 2006, IEEE Transactions on Nuclear Science.

[11]  G T Barnes,et al.  Molybdenum target x-ray spectra: a semiempirical model. , 1991, Medical physics.

[12]  J. Greenleaf,et al.  Selected methods for imaging elastic properties of biological tissues. , 2003, Annual review of biomedical engineering.

[13]  H. Sievänen,et al.  Inaccuracies Inherent in Patient‐Specific Dual‐Energy X‐Ray Absorptiometry Bone Mineral Density Measurements: Comprehensive Phantom‐Based Evaluation , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[14]  B K Rutt,et al.  Polyvinyl alcohol-Fricke hydrogel and cryogel: two new gel dosimetry systems with low Fe3+ diffusion. , 2000, Physics in medicine and biology.

[15]  T. Krouskop,et al.  Elastography: Ultrasonic estimation and imaging of the elastic properties of tissues , 1999, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[16]  John B Weaver,et al.  Initial in vivo experience with steady‐state subzone‐based MR elastography of the human breast , 2003, Journal of magnetic resonance imaging : JMRI.

[17]  R. Sinkus,et al.  High-resolution tensor MR elastography for breast tumour detection. , 2000, Physics in medicine and biology.

[18]  D. Plewes,et al.  Elastic moduli of normal and pathological human breast tissues: an inversion-technique-based investigation of 169 samples , 2007, Physics in medicine and biology.

[19]  Quan Zhang,et al.  Coregistered tomographic x-ray and optical breast imaging: initial results. , 2005, Journal of biomedical optics.

[20]  Armando Manduca,et al.  Imaging elastic properties of biological tissues by low-frequency harmonic vibration , 2003, Proc. IEEE.

[21]  M. E. Masterson,et al.  Epoxy-resin-based tissue substitutes. , 1977, Medical physics.

[22]  P. C. Johns,et al.  X-ray characterisation of normal and neoplastic breast tissues. , 1987, Physics in medicine and biology.

[23]  K Faulkner,et al.  A comparison of mammographic phantoms. , 1994, The British journal of radiology.

[24]  Donald McLean,et al.  The application of breast compression in mammography: a new perspective , 2004 .

[25]  D. Miglioretti,et al.  Individual and Combined Effects of Age, Breast Density, and Hormone Replacement Therapy Use on the Accuracy of Screening Mammography , 2003, Annals of Internal Medicine.

[26]  A. Manduca,et al.  MR elastography of breast cancer: preliminary results. , 2002, AJR. American journal of roentgenology.