Profound Perturbation of the Metabolome in Obesity Is Associated with Health Risk

[1]  Marcelo P. Segura-Lepe,et al.  Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity , 2019, Nature Genetics.

[2]  K. Clément,et al.  MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency , 2018, Nature Medicine.

[3]  J. Després,et al.  Cardiovascular and Metabolic Heterogeneity of Obesity: Clinical Challenges and Implications for Management. , 2018, Circulation.

[4]  Anders M. Dale,et al.  Precision medicine screening using whole-genome sequencing and advanced imaging to identify disease risk in adults , 2017, Proceedings of the National Academy of Sciences.

[5]  Eddy J. Bautista,et al.  Integrative Personal Omics Profiles during Periods of Weight Gain and Loss. , 2018, Cell systems.

[6]  T. Spector,et al.  Acetaminophen (Paracetamol) Use Modifies the Sulfation of Sex Hormones , 2018, EBioMedicine.

[7]  E. Rhee.  Being Metabolically Healthy, the Most Responsible Factor for Vascular Health , 2018, Diabetes & metabolism journal.

[8]  S. Yanovski,et al.  Toward Precision Approaches for the Prevention and Treatment of Obesity. , 2018, JAMA.

[9]  Chunlei Liu,et al.  ClinVar: improving access to variant interpretations and supporting evidence , 2017, Nucleic Acids Res..

[10]  J. Vilariño,et al.  Metabolically healthy obese individuals present similar chronic inflammation level but less insulin-resistance than obese individuals with metabolic syndrome , 2017, PloS one.

[11]  A. Heijboer,et al.  Is There an Association Between Cortisol and Hypertension in Overweight or Obese Children? , 2017, Journal of clinical research in pediatric endocrinology.

[12]  Marcelo P. Segura-Lepe,et al.  Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure underpinning obesity , 2017, Nature Genetics.

[13]  Craig M. Hales,et al.  Prevalence of Obesity Among Adults and Youth: United States, 2015-2016. , 2017, NCHS data brief.

[14]  K. Toulis,et al.  Metabolically Healthy Obese and Incident Cardiovascular Disease Events Among 3.5 Million Men and Women. , 2017, Journal of the American College of Cardiology.

[15]  C. Gieger,et al.  Metabolomic Profiling of Long‐Term Weight Change: Role of Oxidative Stress and Urate Levels in Weight Gain , 2017, Obesity.

[16]  K. Clément,et al.  Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency , 2017, Molecular metabolism.

[17]  Amalio Telenti,et al.  Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites , 2017, Nature Genetics.

[18]  K. Clément,et al.  Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist. , 2016, The New England journal of medicine.

[19]  Jens Nielsen,et al.  Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance. , 2016, Cell metabolism.

[20]  Levi C. T. Pierce,et al.  Deep sequencing of 10,000 human genomes , 2016, Proceedings of the National Academy of Sciences.

[21]  Ming-Huei Chen,et al.  Metabolomic Profiles of Body Mass Index in the Framingham Heart Study Reveal Distinct Cardiometabolic Phenotypes , 2016, PloS one.

[22]  A. Tomiyama,et al.  Hypothalamic-pituitary-adrenal axis dysregulation and cortisol activity in obesity: A systematic review , 2015, Psychoneuroendocrinology.

[23]  Yan Liu,et al.  Global metabolomic profiling targeting childhood obesity in the Hispanic population. , 2015, The American journal of clinical nutrition.

[24]  Eun-Kyoung Kim,et al.  A Metabolomic Approach to Understanding the Metabolic Link between Obesity and Diabetes , 2015, Molecules and cells.

[25]  Y. Tsai,et al.  The metabolome profiling and pathway analysis in metabolic healthy and abnormal obesity , 2015, International Journal of Obesity.

[26]  Fabian J Theis,et al.  Multi-omic signature of body weight change: results from a population-based cohort study , 2015, BMC Medicine.

[27]  Ross M. Fraser,et al.  Genetic studies of body mass index yield new insights for obesity biology , 2015, Nature.

[28]  T. Illig,et al.  Changes in the serum metabolite profile in obese children with weight loss , 2014, European Journal of Nutrition.

[29]  L. Nieman,et al.  Cortisol, obesity and the metabolic syndrome: A cross-sectional study of obese subjects and review of the literature , 2012, Obesity.

[30]  Alireza Moayyeri,et al.  The UK Adult Twin Registry (TwinsUK Resource) , 2012, Twin Research and Human Genetics.

[31]  C. Newgard.  Interplay between lipids and branched-chain amino acids in development of insulin resistance. , 2012, Cell metabolism.

[32]  Ying Liu,et al.  FaST linear mixed models for genome-wide association studies , 2011, Nature Methods.

[33]  S. Dwivedi,et al.  Morning cortisol is lower in obese individuals with normal glucose tolerance , 2011, Diabetes, metabolic syndrome and obesity : targets and therapy.

[34]  Peter Kovacs,et al.  Combined proteomic and metabolomic profiling of serum reveals association of the complement system with obesity and identifies novel markers of body fat mass changes. , 2011, Journal of proteome research.

[35]  A. Garg.  Lipodystrophies: Genetic and Acquired Body Fat Disorders , 2011 .

[36]  Roger J. R. Levesque,et al.  Obesity and Overweight , 2011 .

[37]  J. Hebebrand,et al.  [Obesity and overweight]. , 2009, Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie.

[38]  R. Collins,et al.  Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies , 2009, Lancet.

[39]  W. R. Wikoff,et al.  Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites , 2009, Proceedings of the National Academy of Sciences.

[40]  Remi Rabasa-Lhoret,et al.  The metabolically healthy but obese individual presents a favorable inflammation profile. , 2005, The Journal of clinical endocrinology and metabolism.

[41]  R. Turner,et al.  Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man , 1985, Diabetologia.

[42]  P. Stenson,et al.  Human Gene Mutation Database (HGMD®): 2003 update , 2003, Human mutation.

[43]  E. A. Sims,et al.  What are the physical characteristics associated with a normal metabolic profile despite a high level of obesity in postmenopausal women? , 2001, The Journal of clinical endocrinology and metabolism.

[44]  P. Björntorp,et al.  Obesity and cortisol. , 2000, Nutrition.

[45]  T. Olsson,et al.  Independent effects of obesity and cortisol in predicting cardiovascular risk factors in men and women , 2000, Journal of internal medicine.

[46]  G. Reaven,et al.  Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration. , 1991, JAMA.