The oligogenic model of amyotrophic lateral sclerosis; phenotypes of three Tunisian families

lateral sclerosis a multisystemic neurodegenerative disorder. identification of ALS main genes, dissimilarity of ALS points to poten-tial specific ancestry associations, which may help explain variation in clinical presentation reported in our There is one hypothesis that can be put forth in order to explain this clinical variability, which is the existence of genetic modifiers that affect the disease features. 2 a We performed