Landscape and climatic characteristics associated with human alveolar echinococcosis in France, 1982 to 2007.

Human alveolar echinococcosis (AE) is a severe hepatic disease caused by Echinococcus multilocularis. In France, the definitive and intermediate hosts of E. multilocularis (foxes and rodents, respectively) have a broader geographical distribution than that of human AE. In this two-part study, we describe the link between AE incidence in France between 1982 and 2007 and climatic and landscape characteristics. National-level analysis demonstrated a dramatic increase in AE risk in areas with very cold winters and high annual rainfall levels. Notably, 52% (207/401) of cases resided in French communes (smallest French administrative level) with a mountain climate. The mountain climate communes displayed a 133-fold (95% CI: 95-191) increase in AE risk compared with communes in which the majority of the population resides. A case-control study performed in the most affected areas confirmed the link between AE risk and climatic factors. This arm of the study also revealed that populations residing in forest or pasture areas were at high risk of developing AE. We therefore hypothesised that snow-covered ground may facilitate predators to track their prey, thus increasing E. multilocularis biomass in foxes. Such climatic and landscape conditions could lead to an increased risk of developing AE among humans residing in nearby areas.

[1]  F. Grenouillet,et al.  Detecting nested clusters of human alveolar echinococcosis , 2013, Parasitology.

[2]  Paul R. Torgerson,et al.  A Systematic Review of the Epidemiology of Echinococcosis in Domestic and Wild Animals , 2013, PLoS neglected tropical diseases.

[3]  J. Gaudart,et al.  Populations at Risk for Alveolar Echinococcosis, France , 2013, Emerging infectious diseases.

[4]  D. Pleydell,et al.  Drivers of Echinococcus multilocularis Transmission in China: Small Mammal Diversity, Landscape or Climate? , 2013, PLoS neglected tropical diseases.

[5]  C. Dunoyer,et al.  Expansion géographique du parasite Echinococcus multilocularis chez le renard en France , 2013 .

[6]  F. Raoul,et al.  Westward Spread of Echinococcus multilocularis in Foxes, France, 2005–2010 , 2012, Emerging infectious diseases.

[7]  R. Piarroux,et al.  Clinical features and evolution of alveolar echinococcosis in France from 1982 to 2007: results of a survey in 387 patients. , 2011, Journal of hepatology.

[8]  P. Deplazes,et al.  Age, season and spatio-temporal factors affecting the prevalence of Echinococcus multilocularis and Taenia taeniaeformis in Arvicola terrestris , 2011, Parasites & Vectors.

[9]  P. Kern.  Clinical features and treatment of alveolar echinococcosis , 2010, Current opinion in infectious diseases.

[10]  Daniel Joly,et al.  Les types de climats en France, une construction spatiale , 2010 .

[11]  R. Piarroux,et al.  Multi-locus microsatellite analysis supports the hypothesis of an autochthonous focus of Echinococcus multilocularis in northern Italy. , 2009, International journal for parasitology.

[12]  U. Thelen,et al.  Investigation of Echinococcus multilocularis in red foxes and their possible relationship to human alveolar echinococcosis. , 2009 .

[13]  Qian Wang,et al.  Landscape Composition and Spatial Prediction of Alveolar Echinococcosis in Southern Ningxia, China , 2008, PLoS neglected tropical diseases.

[14]  M. Poulle,et al.  Ecological and biological factors involved in the transmission of Echinococcus multilocularis in the French Ardennes , 2008, Journal of Helminthology.

[15]  Sébastien Lê,et al.  FactoMineR: An R Package for Multivariate Analysis , 2008 .

[16]  M. Poulle,et al.  Fox faeces and vole distribution on a local range: ecological data in a parasitological perspective for Echinococcus multilocularis. , 2007, Parasite.

[17]  Qian Wang,et al.  Socioeconomic and behavior risk factors of human alveolar echinococcosis in Tibetan communities in Sichuan, People's Republic of China. , 2006, The American journal of tropical medicine and hygiene.

[18]  D. McManus,et al.  Unique family clustering of human echinococcosis cases in a chinese community. , 2006, The American journal of tropical medicine and hygiene.

[19]  G. Mantion,et al.  Survival strategy of Echinococcus multilocularis in the human host. , 2006, Parasitology international.

[20]  F. Tourneux,et al.  Modéliser et représenter la vulnérabilité paysagère dans un contexte épidémiologique : les hôtes intermédiaires d'Echinococcus multilocularis , 2006 .

[21]  A. Schliephake,et al.  [Echinococcus multilocularis in red foxes in Saxony-Anhalt: identification of areas of increased risk of infestation and association of the infestation probability with the average annual maximum temperature]. , 2005, Berliner und Munchener tierarztliche Wochenschrift.

[22]  W. Gaus,et al.  Risk Factors for Alveolar Echinococcosis in Humans , 2004, Emerging infectious diseases.

[23]  Qian Wang,et al.  Epidemiology of alveolar echinococcosis with particular reference to China and Europe , 2003, Parasitology.

[24]  F. Raoul,et al.  Interactions between landscape changes and host communities can regulate Echinococcus multilocularis transmission , 2003, Parasitology.

[25]  P. Tiberghien,et al.  Polymorphisms of the TAP1 and TAP2 genes in human alveolar echinococcosis. , 2003, European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics.

[26]  H. Auer,et al.  European Echinococcosis Registry: Human Alveolar Echinococcosis, Europe, 1982–2000 , 2003, Emerging infectious diseases.

[27]  D. McManus,et al.  Aetiology: parasites and life-cycles , 2001 .

[28]  C. Fìlice,et al.  Echinococcosis in humans: clinical aspects, diagnosis and treatment. , 2001 .

[29]  F. Meslin,et al.  WHO/OIE manual on echinococcosis in humans and animals: a public health problem of global concern. , 2001 .

[30]  J. Quéré,et al.  An epidemiological and ecological study of human alveolar echinococcosis transmission in south Gansu, China. , 2000, Acta tropica.

[31]  F. Raoul,et al.  Epidemiology of alveolar echinococcosis in Xinjiang Uygur autonomous region, China: a preliminary analysis , 2000, Annals of tropical medicine and parasitology.

[32]  H. Auer,et al.  Domestic pets as risk factors for alveolar hydatid disease in Austria. , 1998, American journal of epidemiology.

[33]  R. Carbiener,et al.  Ecologie de l'échinococcose alvéolaire en Alsace: le parasitisme du renard roux (Vulpes vulpes L.) , 1989 .

[34]  P. Delattre,et al.  Caractéristiques écologiques et épidémiologiques de l'Echinococcus multilocularis au cours d'un cycle complet des populations d'un hôte intermédiaire (Microtus arvalis) , 1988 .

[35]  A. Lanier,et al.  Risk factors for infection with Echinococcus multilocularis in Alaska. , 1988, The American journal of tropical medicine and hygiene.

[36]  J. D. Smyth,et al.  The Biology of Echinococcus and hydatid disease , 1986 .