+ Dendritic Cells α Mouse CD4+ and CD8 Bcl6 Is Required for the Development of

Masahiko Hatano, Seiji Okada and Takeshi TokuhisaSatoshi Horigome, Hirohito Ichii, Masafumi Arima, Hiromi Ohtsuka, Akemi Sakamoto, Jing Pan, Sumina Inage,http://www.jimmunol.org/content/186/1/255doi: 10.4049/jimmunol.0903714December 2010;J Immunol€2011; 186:255-263; Prepublished online 3Referenceshttp://www.jimmunol.org/content/186/1/255.full#ref-list-1This article cites 50 articles, 28 of which you can access for free at: Subscriptionshttp://jimmunol.org/subscriptionsInformation about subscribing to The Journal of Immunology is online at: Permissionshttp://www.aai.org/ji/copyright.htmlSubmit copyright permission requests at: Email Alertshttp://jimmunol.org/cgi/alerts/etocReceive free email-alerts when new articles cite this article. Sign up at:

[1]  I. Lossos The endless complexity of lymphocyte differentiation and lymphomagenesis: IRF-4 downregulates BCL6 expression. , 2007, Cancer cell.

[2]  Andreas Radbruch,et al.  T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[3]  R. Maldonado-López,et al.  Cytokines Regulate the Capacity of CD8α+ and CD8α− Dendritic Cells to Prime Th1/Th2 Cells In Vivo1 , 2001, The Journal of Immunology.

[4]  M. Privalsky,et al.  Components of the SMRT Corepressor Complex Exhibit Distinctive Interactions with the POZ Domain Oncoproteins PLZF, PLZF-RARα, and BCL-6* , 1998, The Journal of Biological Chemistry.

[5]  D. Leprince,et al.  Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[6]  R. Steinman,et al.  Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor , 1992, The Journal of experimental medicine.

[7]  Yong‐jun Liu,et al.  Mouse and human dendritic cell subtypes , 2002, Nature Reviews Immunology.

[8]  N. Aoki,et al.  Recognition DNA sequence of a novel putative transcription factor, BCL6. , 1994, Biochemical and biophysical research communications.

[9]  D. Jarrossay,et al.  Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow , 2007, Nature Immunology.

[10]  M. Hatano,et al.  Role for Bcl-6 in the generation and maintenance of memory CD8+ T cells , 2002, Nature Immunology.

[11]  P. Pandolfi,et al.  The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation , 1997, Nature Genetics.

[12]  N. Seki,et al.  Bcl6 controls granzyme B expression in effector CD8+ T cells , 2006, European journal of immunology.

[13]  N. Zeleznik-Le,et al.  BCL6 encodes a sequence‐specific DNA‐binding Protein , 1995, Genes, chromosomes & cancer.

[14]  B. Pulendran,et al.  Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells. , 2000, Blood.

[15]  S. Hida,et al.  Defective development of splenic and epidermal CD4+ dendritic cells in mice deficient for IFN regulatory factor-2. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[16]  N. Aoki,et al.  Gene involved in the 3q27 translocation associated with B-cell lymphoma, BCL5, encodes a Krüppel-like zinc-finger protein. , 1994, Blood.

[17]  Y. Kohno,et al.  Bcl6 Is a Transcriptional Repressor for the IL-18 Gene1 , 2003, The Journal of Immunology.

[18]  G. Belz,et al.  Cross‐presentation, dendritic cell subsets, and the generation of immunity to cellular antigens , 2004, Immunological reviews.

[19]  L. Staudt,et al.  Transcriptional repression by the proto-oncogene BCL-6. , 1996, Oncogene.

[20]  T. Nakahata,et al.  TH2 dominance and defective development of a CD8+ dendritic cell subset in Id2-deficient mice. , 2003, The Journal of allergy and clinical immunology.

[21]  C. Arias,et al.  CD8alpha+ dendritic cells originate from the CD8alpha- dendritic cell subset by a maturation process involving CD8alpha, DEC-205, and CD24 up-regulation. , 2002, Blood.

[22]  K Offit,et al.  Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma. , 1993, Science.

[23]  Ryan T. Phan,et al.  The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells , 2004, Nature.

[24]  M. Hatano,et al.  Bcl6 is essential for the generation of long-term memory CD4+ T cells. , 2007, International immunology.

[25]  A. Sher,et al.  In Vivo Microbial Stimulation Induces Rapid CD40 Ligand–independent Production of Interleukin 12 by Dendritic Cells and their Redistribution to T Cell Areas , 1997, The Journal of experimental medicine.

[26]  H. Tilly,et al.  LAZ3, a novel zinc–finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas , 1993, Nature Genetics.

[27]  M. Hatano,et al.  The role of Bcl6 in mature cardiac myocytes. , 1999, Cardiovascular research.

[28]  M. Hatano,et al.  Disruption of the Bcl6 Gene Results in an Impaired Germinal Center Formation , 1997, The Journal of experimental medicine.

[29]  D. Leprince,et al.  Multiple domains participate in distance-independent LAZ3/BCL6-mediated transcriptional repression. , 1996, Biochemical and biophysical research communications.

[30]  M. Kubo,et al.  A Putative Silencer Element in the IL-5 Gene Recognized by Bcl61 , 2002, The Journal of Immunology.

[31]  P. Hertzog,et al.  Differential Production of IL-12, IFN-α, and IFN-γ by Mouse Dendritic Cell Subsets1 , 2001, The Journal of Immunology.

[32]  R S Chaganti,et al.  BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[33]  D. Leprince,et al.  The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain. , 1995, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[34]  L. Staudt,et al.  Control of inflammation, cytokine expression, and germinal center formation by BCL-6. , 1997, Science.

[35]  F. Belardelli,et al.  ICSBP Is Essential for the Development of Mouse Type I Interferon-producing Cells and for the Generation and Activation of CD8α+ Dendritic Cells , 2002, The Journal of experimental medicine.

[36]  M. Hatano,et al.  The murine BCL6 gene is induced in activated lymphocytes as an immediate early gene. , 1995, Oncogene.

[37]  Melanie Bahlo,et al.  Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo , 2007, Nature Immunology.

[38]  M. Bevan,et al.  Cd8+ but Not Cd8− Dendritic Cells Cross-Prime Cytotoxic T Cells in Vivo , 2000, The Journal of experimental medicine.

[39]  P. Lipsky,et al.  Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein , 2006, The Journal of experimental medicine.

[40]  C Caux,et al.  Immunobiology of dendritic cells. , 2000, Annual review of immunology.

[41]  L. Donehower,et al.  Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours , 1992, Nature.

[42]  C. Ardavı́n Origin, precursors and differentiation of mouse dendritic cells , 2003, Nature Reviews Immunology.

[43]  Li Wu,et al.  Cutting Edge: Generation of Splenic CD8+ and CD8− Dendritic Cell Equivalents in Fms-Like Tyrosine Kinase 3 Ligand Bone Marrow Cultures1 , 2005, The Journal of Immunology.

[44]  S. Mori,et al.  BCL-6 gene product, a 92- to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts. , 1995, Blood.

[45]  K. Offit,et al.  BCL-6 protein is expressed in germinal-center B cells. , 1995, Blood.

[46]  H. Broxmeyer,et al.  BCL-6 negatively regulates macrophage proliferation by suppressing autocrine IL-6 production. , 2005, Blood.

[47]  S. Rose-John,et al.  Transcriptional profiling identifies Id2 function in dendritic cell development , 2003, Nature Immunology.

[48]  P. Pandolfi,et al.  BCL-6 regulates chemokine gene transcription in macrophages , 2000, Nature Immunology.