Transitioning to Safer Chemicals in Academic Research Laboratories: Lessons Learned at the University of Washington

Chemicals are an integral component of laboratory activities in academia but minimizing hazards and environmental impacts of chemicals is challenging. This paper describes how laboratories in University of Washington’s Department of Environmental and Occupational Health Sciences (UW DEOHS) partnered with the UW Green Laboratory Program to explore approaches for assisting laboratories to adopt green chemistry principles and select safer chemicals. Chemical inventories, purchasing records, and hazardous waste data were used to quantitate chemical use in DEOHS. Characterizing chemical use based on the data sources provided the project team with a summary of the high volume chemicals used by departmental laboratories. As a way to target chemicals that are highly hazardous but not used in large masses/volumes, laboratory managers were asked about highly hazardous or toxic chemicals they used. Two chemicals were selected for alternatives assessments and developed into case studies that represent different barri...

[1]  Katy A. Muzikar,et al.  1H and 13C NMR assignments for the cyanine dyes SYBR Safe and thiazole orange. , 2012, The Journal of organic chemistry.

[2]  Peter J Dunn,et al.  The importance of green chemistry in process research and development. , 2012, Chemical Society reviews.

[3]  Concepción Jiménez-González,et al.  The evolution of life cycle assessment in pharmaceutical and chemical applications – a perspective , 2014 .

[4]  Catherine Rudisill,et al.  Advancing safer alternatives through functional substitution. , 2015, Environmental science & technology.

[5]  Paul T Anastas,et al.  Barriers to the implementation of green chemistry in the United States. , 2012, Environmental science & technology.

[6]  Matthew H. Ranson,et al.  The Impact of Pollution Prevention on Toxic Environmental Releases from U.S. Manufacturing Facilities. , 2015, Environmental science & technology.

[7]  M. Weiner,et al.  Kits and their unique role in molecular biology: a brief retrospective. , 2008, BioTechniques.

[8]  Paul T. Anastas,et al.  Twenty Years OF Green Chemistry , 2011 .

[9]  M. Tobiszewski,et al.  Scoring of solvents used in analytical laboratories by their toxicological and exposure hazards. , 2015, Ecotoxicology and environmental safety.

[10]  Marek Tobiszewski,et al.  Green Chemistry Metrics with Special Reference to Green Analytical Chemistry , 2015, Molecules.

[11]  John Andraos,et al.  Green chemistry teaching in higher education: a review of effective practices , 2012 .

[12]  R. E. Lee,et al.  Chemical alternatives assessment: enabling substitution to safer chemicals. , 2010, Environmental science & technology.

[13]  Julie M Schoenung,et al.  Comparative alternative materials assessment to screen toxicity hazards in the life cycle of CIGS thin film photovoltaics. , 2013, Journal of hazardous materials.

[14]  Yadong Li,et al.  Green chemistry for nanoparticle synthesis. , 2015, Chemical Society reviews.

[15]  L. H. Keith,et al.  Green analytical methodologies. , 2007, Chemical reviews.

[16]  Roger A. Sheldon,et al.  Overcoming barriers to green chemistry in the pharmaceutical industry – the Green Aspiration Level™ concept , 2015 .

[17]  John D. Hayler,et al.  CHEM21 selection guide of classical- and less classical-solvents , 2016 .

[18]  Concepción Jiménez-González,et al.  Expanding GSK's solvent selection guide ― embedding sustainability into solvent selection starting at medicinal chemistry , 2011 .

[19]  Scott I. Hsieh,et al.  An Approach To Enhance the Safety Culture of an Academic Chemistry Research Laboratory by Addressing Behavioral Factors , 2016 .

[20]  Francisco Pena-Pereira,et al.  Perspectives on the replacement of harmful organic solvents in analytical methodologies: a framework toward the implementation of a generation of eco-friendly alternatives , 2015 .

[21]  Thierry Meyer How About Safety and Risk Management in Research and Education , 2012 .

[22]  John Andraos,et al.  Simplified Application of Material Efficiency Green Metrics to Synthesis Plans: Pedagogical Case Studies Selected from Organic Syntheses , 2015 .

[23]  Gregory J Howard,et al.  Chemical alternatives assessment: the case of flame retardants. , 2014, Chemosphere.