Stereoselective total synthesis of (+)-norrisolide.

In a convergent approach to the marine natural product (þ)-norrisolide (1) the two bicyclic ring systems are coupled through the C9 C10 bond to assemble the carbon framework in a late stage of the synthesis. Other highlights of the synthetic strategy include the formation of the unusual fused g-lactone–g-lactol motif of 1 through a sequence of oxidation reactions. T. P. Brady, S. H. Kim, K. Wen, E. A. Theodorakis* 739 – 742