The effect of brain tumor angiogenesis on the in vivo relationship between the gradient‐echo relaxation rate change (ΔR2*) and contrast agent (MION) dose

To determine in vivo if the susceptibility calibration factor for gradient‐echo imaging (kG), which characterizes the relationship between the tissue T2* relaxation rate change (ΔR2*) and tissue contrast agent concentration, is independent of tissue type and condition; in addition, to assess the consequences of such an assumption on the use of relative cerebral blood volume (rCBV) measurements as a direct index of tumor angiogenesis.

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