Multiple Sites of Insecticidal Action in Ionotropic GABA Receptors

[1]  Kathleen A. Durkin,et al.  Novel GABA receptor pesticide targets. , 2015, Pesticide biochemistry and physiology.

[2]  W. Sieghart.  Allosteric modulation of GABAA receptors via multiple drug-binding sites. , 2015, Advances in pharmacology.

[3]  M. Asahi,et al.  Differential mechanisms of action of the novel γ-aminobutyric acid receptor antagonist ectoparasiticides fluralaner (A1443) and fipronil. , 2015, Pest management science.

[4]  H. Nakajima,et al.  Competitive antagonism of insect GABA receptors by 4-substituted 5-(4-piperidyl)-3-isothiazolols. , 2014, Bioorganic & medicinal chemistry.

[5]  Genyan Liu,et al.  Synthesis of 1,3-di- and 1,3,4-trisubstituted 1,6-dihydro-6-iminopyridazines as competitive antagonists of insect GABA receptors , 2014 .

[6]  K. Hirase,et al.  Effects of novel meta-diamide insecticides on GABA type A receptors α1β2γ2 and α1β3γ2 and on glycine receptor α1β , 2014 .

[7]  P. Confalone,et al.  Discovery and mode of action of afoxolaner, a new isoxazoline parasiticide for dogs. , 2014, Veterinary parasitology.

[8]  T. Ilg,et al.  The novel isoxazoline ectoparasiticide fluralaner: selective inhibition of arthropod γ-aminobutyric acid- and L-glutamate-gated chloride channels and insecticidal/acaricidal activity. , 2014, Insect biochemistry and molecular biology.

[9]  F. Ozoe,et al.  Expression pattern and function of alternative splice variants of glutamate-gated chloride channel in the housefly Musca domestica. , 2014, Insect biochemistry and molecular biology.

[10]  G. Johnston.  Muscimol as an Ionotropic GABA Receptor Agonist , 2014, Neurochemical Research.

[11]  J. Casida,et al.  Insect γ-aminobutyric acid receptors and isoxazoline insecticides: toxicological profiles relative to the binding sites of [³H]fluralaner, [³H]-4'-ethynyl-4-n-propylbicycloorthobenzoate, and [³H]avermectin. , 2014, Journal of agricultural and food chemistry.

[12]  K. Hirase,et al.  Insecticidal 3-benzamido-N-phenylbenzamides specifically bind with high affinity to a novel allosteric site in housefly GABA receptors. , 2013, Pesticide biochemistry and physiology.

[13]  M. Azuma,et al.  Differential distribution of glutamate- and GABA-gated chloride channels in the housefly Musca domestica. , 2013, Journal of insect physiology.

[14]  K. Hirase,et al.  A comparison of the modes of action of novel meta-diamide insecticides and conventional noncompetitive antagonists on the Spodoptera litura RDL GABA receptor , 2013 .

[15]  C. Holyoke,et al.  4-Azolylphenyl isoxazoline insecticides acting at the GABA gated chloride channel. , 2013, Bioorganic & medicinal chemistry letters.

[16]  K. Hirase,et al.  Meta-diamide insecticides acting on distinct sites of RDL GABA receptor from those for conventional noncompetitive antagonists. , 2013, Insect biochemistry and molecular biology.

[17]  R. Sarpong,et al.  New GABA/glutamate receptor target for [³H]isoxazoline insecticide. , 2013, Chemical research in toxicology.

[18]  Kathleen A. Durkin,et al.  Neuroactive insecticides: targets, selectivity, resistance, and secondary effects. , 2013, Annual review of entomology.

[19]  Y. Ozoe.  γ-Aminobutyrate- and Glutamate-gated Chloride Channels as Targets of Insecticides , 2013 .

[20]  A. Kinoshita,et al.  The A2′N Mutation of the RDL &ggr;-Aminobutyric Acid Receptor Conferring Fipronil Resistance in Laodelphax striatellus (Hemiptera: Delphacidae) , 2011, Journal of economic entomology.

[21]  X. Ju,et al.  Synthesis and structure-activity relationship analysis of bicyclophosphorothionate blockers with selectivity for housefly gamma-aminobutyric acid receptor channels. , 2010, Pest management science.

[22]  K. Hirase,et al.  Mutation of the GABA receptor associated with fipronil resistance in the whitebacked planthopper, Sogatella furcifera , 2010 .

[23]  M. Asahi,et al.  The antiparasitic isoxazoline A1443 is a potent blocker of insect ligand-gated chloride channels. , 2010, Biochemical and biophysical research communications.

[24]  K. Matsuda,et al.  γ-Aminobutyric Acid Receptors: A Rationale for Developing Selective Insect Pest Control Chemicals , 2009 .

[25]  K. Hirase,et al.  Molecular cloning of a GABA receptor subunit from Laodelphax striatella (Fallén) and patch clamp analysis of the homo‐oligomeric receptors expressed in a Drosophila cell line , 2007, Insect molecular biology.

[26]  F. Ozoe,et al.  The channel-lining 6′ amino acid in the second membrane-spanning region of ionotropic GABA receptors has more profound effects on 4′-ethynyl-4-n-propylbicycloorthobenzoate binding than the 2′ amino acid , 2007, Invertebrate Neuroscience.

[27]  G. Le Goff,et al.  Resistance to fipronil in Drosophila simulans: influence of two point mutations in the RDL GABA receptor subunit , 2005, Journal of neurochemistry.

[28]  J. Casida,et al.  GABA receptor subunit composition relative to insecticide potency and selectivity. , 2001, Toxicology letters.

[29]  Tretter,et al.  Identification of Amino Acid Residues of GABAA Receptor Subunits Contributing to the Formation and Affinity of the tert‐Butylbicyclophosphorothionate Binding Site , 2000, Journal of neurochemistry.

[30]  T. Wu,et al.  Interaction of Non-competitive Blockers within the γ-Aminobutyric Acid Type A Chloride Channel Using Chemically Reactive Probes as Chemical Sensors for Cysteine Mutants* , 1999, The Journal of Biological Chemistry.

[31]  J. Steinbach,et al.  Bicuculline and Gabazine Are Allosteric Inhibitors of Channel Opening of the GABAA Receptor , 1997, The Journal of Neuroscience.

[32]  D. Cully,et al.  Identification of a Drosophila melanogaster Glutamate-gated Chloride Channel Sensitive to the Antiparasitic Agent Avermectin* , 1996, The Journal of Biological Chemistry.

[33]  J. C. Steichen,et al.  Conservation of cyclodiene insecticide resistance‐associated mutations in insects , 1993, Insect molecular biology.

[34]  J. Casida,et al.  GABA-gated chloride channel: Binding site for 4′-ethynyl-4-n-[2,3-3H2]propylbicycloorthobenzoate ([3H]EBOB) in vertebrate brain and insect head , 1992 .

[35]  C. Newland,et al.  On the mechanism of action of picrotoxin on GABA receptor channels in dissociated sympathetic neurones of the rat. , 1992, The Journal of physiology.

[36]  F. Ehlert,et al.  Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods. , 1988, Molecular pharmacology.

[37]  A. Constanti,et al.  Studies on the mechanism of action of picrotoxinin and other convulsants at the crustacean muscle GABA receptor , 1986, Proceedings of the Royal Society of London. Series B. Biological Sciences.